Research output per year
Research output per year
Personal profile
Research interests
B cells and secreted antibodies (immunoglobulins) are essential for host defence during infections; they constantly edit the elements of immunoglobulin genes during B-cell development and immune response to achieve the maximally tailored antibody protection against specific antigens. These editing mechanisms continuously shape the landscape of antibody repertoire and record, within immunoglobulin genes, the biomedical information concerning the B-cell development and antibody response pattern. My research focus is to delineate and characterise normal and pathogenic antibody responses by thoroughly profiling the cellular and genetic components of B cells.
I employ next-generation sequencing and microfluidics systems in combination with state-of-the-art bioinformatics to probe B cells in projects including
(1) MRC/GSK Alliance: Local and peripheral B cell responses in experimental rhinovirus (common cold) infection in asthma (exacerbation);
(2) IgE developmental pathways in allergic and healthy humans and in the elderly;
(3) Role of bone marrow-resident B cells in the homeostasis of long-term IgE memory in asthma and allergy;
(4) Lab-on-a-chip, microfluidic analysis of single B cells.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, Immunobiology:High-throughput sequencing analysis of normal human B-cell repertoires , King's College London
Award Date: 1 Jan 2011
Fingerprint
Dive into the research topics where Bryan Wu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
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Influence of seasonal exposure to grass pollen on local and peripheral blood IgE repertoires in patients with allergic rhinitis
Wu, Y.-C., James, L., Vander Heiden, J., Uduman, M., Durham, S., Kleinstein, S., Kipling, D. & Gould, H., Sept 2014, In: Journal of Allergy and Clinical Immunology. 134, 3, p. 604-612 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile44 Citations (Scopus)239 Downloads (Pure) -
IgE repertoire and immunological memory: compartmental regulation and antibody function: Immunoglobulin repertoire and allergy
Gould, H. J. & Wu, Y.-C. B., 20 Jul 2018, (E-pub ahead of print) In: International Immunology. 30, 9Research output: Contribution to journal › Review article › peer-review
Open AccessFile24 Citations (Scopus)160 Downloads (Pure) -
Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue
Zhao, Y., Uduman, M., Siu, J., Tull, T. J., Sanderson, J., Wu, Y.-C. B., Zhou, J. Q., Petrov, N., Ellis, R. J., Todd, S. K., Chavele, K.-M., Guesdon, W. W. J., Vossenkamper, A., Jassem, W., D’Cruz, D., Fear, D. J., John, S., Scheel-Toellner, D., hopkins, C. & Moreno, E. & 6 others, , 21 Sept 2018, In: Nature Communications. 9, 1, 15 p., 3857.Research output: Contribution to journal › Article › peer-review
Open AccessFile78 Citations (Scopus)352 Downloads (Pure) -
Insight into Rhinovirus-Induced Asthma Exacerbation Using High-Throughput Immunosequencing of B-Cell Repertoires: Programs and Abstracts of Papers to be Presented During Scientific Sessions: 2017 AAAAI Annual Meeting.All abstracts are strictly embargoed until the date of presentation at the 2017 Annual Meeting. Contact [email protected] with questions.
Bryan Wu, Y.-C., Rosenfeld, A. M., Upton, N., Dhariwal, J., Hershberg, U., Kipling, D., Johnston, S. L. & Gould, H. J., Feb 2017, In: Journal of Allergy and Clinical Immunology. 139, 2, Supplement, p. AB80Research output: Contribution to journal › Article › peer-review
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Antibodies and superantibodies in patients with chronic rhinosinusitis with nasal polyps
Chen, J. B., James, L. K., Davies, A. M., Wu, Y. C. B., Rimmer, J., Lund, V. J., Chen, J. H., McDonnell, J. M., Chan, Y. C., Hutchins, G. H., Chang, T. W., Sutton, B. J., Kariyawasam, H. H. & Gould, H. J., 19 Sept 2016, In: Journal of Allergy and Clinical Immunology.Research output: Contribution to journal › Article › peer-review
Open AccessFile39 Citations (Scopus)191 Downloads (Pure)
Projects
- 6 Finished
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Quantitative multiplex FRET detection of IgG4- & IL10- secreting B Regulatory 1 cells in microfluidics
Wu, B. (Primary Investigator) & Sutton, B. (Co-Investigator)
14/04/2017 → 31/12/2018
Project: Research
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Development of a novel research approach to understand how IgE B cells cause asthma
Wu, B. (Primary Investigator) & Gould, H. (Co-Investigator)
4/04/2016 → 3/10/2017
Project: Research
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Genetic and Functional Characterization of the IgE Repertoire and Compartmental Regulation of IgE Activity in the Pathogenesis of Asthma
Gould, H. (Primary Investigator), Corrigan, C. (Co-Investigator), Tindall, L. (Co-Investigator) & Wu, B. (Co-Investigator)
15/12/2015 → 14/12/2018
Project: Research
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High-throughput analysis of local and peripheral IgE repertoires in asthma
Gould, H. (Primary Investigator) & Wu, B. (Co-Investigator)
1/09/2014 → 31/08/2015
Project: Research
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Genetic and functional characterisation of the IgE repertoire and compartmental regulation of IgE activity in the pathogenesis and treatment of asthma
Gould, H. (Primary Investigator), Corrigan, C. (Co-Investigator), Tindall, L. (Co-Investigator) & Wu, B. (Co-Investigator)
1/09/2014 → 31/08/2019
Project: Research
Activities
- 1 Types of Public engagement and outreach - Media article or participation
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ARE HAY FEVER SUFFERERS LED BY THEIR NOSE?
Wu, B. (Contributor)
Sept 2014Activity: Other › Types of Public engagement and outreach - Media article or participation