Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks

Suling Liu; Christophe Ginestier; Sing J. Ou; Shawn G. Clouthier; Shivani H. Patel; Florence Monville; Hasan Korkaya; Amber Heath; Julie Dutcher; Celina G. Kleer; Younghun Jung; Gabriela Dontu; Russell Taichman; Max S. Wicha

doi:10.1158/0008-5472.CAN-10-0538

Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks

Suling Liu, Christophe Ginestier, Sing J. Ou, Shawn G. Clouthier, Shivani H. Patel, Florence Monville, Hasan Korkaya, Amber Heath, Julie Dutcher, Celina G. Kleer, Younghun Jung, Gabriela Dontu, Russell Taichman, Max S. Wicha

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527 Citations (Scopus)

Abstract

We have used in vitro and mouse xenograft models to examine the interaction between breast cancer stem cells (CSC) and bone marrow-derived mesenchymal stem cells (MSC). We show that both of these cell populations are organized in a cellular hierarchy in which primitive aldehyde dehydrogenase expressing mesenchymal cells regulate breast CSCs through cytokine loops involving IL6 and CXCL7. In NOD/SCID mice, labeled MSCs introduced into the tibia traffic to sites of growing breast tumor xenografts where they accelerated tumor growth by increasing the breast CSC population. With immunochemistry, we identified MSC-CSC niches in these tumor xenografts as well as in frozen sections from primary human breast cancers. Bone marrow-derived MSCs may accelerate human breast tumor growth by generating cytokine networks that regulate the CSC population. Cancer Res; 71(2); 614-24. (C) 2011 AACR.

Original language	English
Pages (from-to)	614 - 624
Number of pages	11
Journal	Cancer Research
Volume	71
Issue number	2
DOIs	https://doi.org/10.1158/0008-5472.CAN-10-0538
Publication status	Published - 15 Jan 2011

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10.1158/0008-5472.CAN-10-0538

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title = "Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks",

abstract = "We have used in vitro and mouse xenograft models to examine the interaction between breast cancer stem cells (CSC) and bone marrow-derived mesenchymal stem cells (MSC). We show that both of these cell populations are organized in a cellular hierarchy in which primitive aldehyde dehydrogenase expressing mesenchymal cells regulate breast CSCs through cytokine loops involving IL6 and CXCL7. In NOD/SCID mice, labeled MSCs introduced into the tibia traffic to sites of growing breast tumor xenografts where they accelerated tumor growth by increasing the breast CSC population. With immunochemistry, we identified MSC-CSC niches in these tumor xenografts as well as in frozen sections from primary human breast cancers. Bone marrow-derived MSCs may accelerate human breast tumor growth by generating cytokine networks that regulate the CSC population. Cancer Res; 71(2); 614-24. (C) 2011 AACR.",

author = "Suling Liu and Christophe Ginestier and Ou, {Sing J.} and Clouthier, {Shawn G.} and Patel, {Shivani H.} and Florence Monville and Hasan Korkaya and Amber Heath and Julie Dutcher and Kleer, {Celina G.} and Younghun Jung and Gabriela Dontu and Russell Taichman and Wicha, {Max S.}",

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doi = "10.1158/0008-5472.CAN-10-0538",

language = "English",

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journal = "Cancer Research",

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TY - JOUR

T1 - Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks

AU - Liu, Suling

AU - Ginestier, Christophe

AU - Ou, Sing J.

AU - Clouthier, Shawn G.

AU - Patel, Shivani H.

AU - Monville, Florence

AU - Korkaya, Hasan

AU - Heath, Amber

AU - Dutcher, Julie

AU - Kleer, Celina G.

AU - Jung, Younghun

AU - Dontu, Gabriela

AU - Taichman, Russell

AU - Wicha, Max S.

PY - 2011/1/15

Y1 - 2011/1/15

N2 - We have used in vitro and mouse xenograft models to examine the interaction between breast cancer stem cells (CSC) and bone marrow-derived mesenchymal stem cells (MSC). We show that both of these cell populations are organized in a cellular hierarchy in which primitive aldehyde dehydrogenase expressing mesenchymal cells regulate breast CSCs through cytokine loops involving IL6 and CXCL7. In NOD/SCID mice, labeled MSCs introduced into the tibia traffic to sites of growing breast tumor xenografts where they accelerated tumor growth by increasing the breast CSC population. With immunochemistry, we identified MSC-CSC niches in these tumor xenografts as well as in frozen sections from primary human breast cancers. Bone marrow-derived MSCs may accelerate human breast tumor growth by generating cytokine networks that regulate the CSC population. Cancer Res; 71(2); 614-24. (C) 2011 AACR.

AB - We have used in vitro and mouse xenograft models to examine the interaction between breast cancer stem cells (CSC) and bone marrow-derived mesenchymal stem cells (MSC). We show that both of these cell populations are organized in a cellular hierarchy in which primitive aldehyde dehydrogenase expressing mesenchymal cells regulate breast CSCs through cytokine loops involving IL6 and CXCL7. In NOD/SCID mice, labeled MSCs introduced into the tibia traffic to sites of growing breast tumor xenografts where they accelerated tumor growth by increasing the breast CSC population. With immunochemistry, we identified MSC-CSC niches in these tumor xenografts as well as in frozen sections from primary human breast cancers. Bone marrow-derived MSCs may accelerate human breast tumor growth by generating cytokine networks that regulate the CSC population. Cancer Res; 71(2); 614-24. (C) 2011 AACR.

U2 - 10.1158/0008-5472.CAN-10-0538

DO - 10.1158/0008-5472.CAN-10-0538

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SP - 614

EP - 624

JO - Cancer Research

JF - Cancer Research

IS - 2

ER -

Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks

Abstract

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