@article{655850a412ef480eaf467bf8444a8c12,
title = "Clinical practice guidelines for management of hyperglycaemia in adults with diabetic kidney disease",
abstract = "A significant percentage of people with diabetes develop chronic kidney disease and diabetes is also a leading cause of end-stage kidney disease (ESKD). The term diabetic kidney disease (DKD) includes both diabetic nephropathy (DN) and diabetes mellitus and chronic kidney disease (DM CKD). DKD is associated with high morbidity and mortality, which are predominantly related to cardiovascular disease. Hyperglycaemia is a modifiable risk factor for cardiovascular complications and progression of DKD. Recent clinical trials of people with DKD have demonstrated improvement in clinical outcomes with sodium glucose co-transporter-2 (SGLT-2) inhibitors. SGLT-2 inhibitors have significantly reduced progression of DKD and onset of ESKD and these reno-protective effects are independent of glucose lowering. At the time of this update Canagliflozin and Dapagliflozin have been approved for delaying the progression of DKD. The Association of British Clinical Diabetologists (ABCD) and UK Kidney Association (UKKA) Diabetic Kidney Disease Clinical Speciality Group have undertaken a literature review and critical appraisal of the available evidence to inform clinical practice guidelines for management of hyperglycaemia in adults with DKD. This 2021 guidance is for the variety of clinicians who treat people with DKD, including GPs and specialists in diabetes, cardiology and nephrology.",
author = "Janaka Karalliedde and Peter Winocour and Chowdhury, {Tahseen A.} and Parijat De and Frankel, {Andrew H.} and Montero, {Rosa M.} and Ana Pokrajac and Debasish Banerjee and Indranil Dasgupta and Damian Fogarty and Adnan Sharif and Mona Wahba and Mark, {Patrick B.} and Sagen Zac-Varghese and Patel, {Dipesh C.} and Bain, {Stephen C.}",
note = "Funding Information: Stephen Bain has received honoraria, teaching and research sponsorship/grants from: Abbott, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Merck Sharp & Dohme, Novo Nordisk, Roche and Sanofi Aventis. He has also received funding for the development of educational programmes from: Elsevier, OmniaMed and Medscape. He is a partner in Glycosmedia, which carries sponsorship declared on its website. Debasish Banerjee was previously funded for research by the British Heart Foundation (BHF). He is funded by ESR AstraZeneca for clinical trials. He has received speaker fees from Vifor Pharma and AstraZeneca Tahseen Chowdhury declares no conflicts of interest. Dipesh Patel has received honoraria for advisory work and/or lecture fees from AstraZeneca, Boehinger Ingelheim Eli Lilly, MSD and Napp Pharmaceuticals, Novo Nordisk and Sanofi Indranil Dasgupta has previously received research grants from Medtronic and Daiichi Sankyo. He has been a member of advisory committees and received educational grants from AstraZeneca, Amgen, Sanofi, MSD, Pfizer, GSK, Mitsubishi Pharma, Otsuka, Vifor Pharmaceuticals, Fresenius and Roche. Parijat De has received honoraria for educational meetings from AstraZeneca, Janssen, Boehringer Ingelheim, Novo, Sanofi, Novartis, Abbott, MSD, Takeda, Roche, Lilly, Ascensia, BD, Internis, GSK, Menarini, Bayer and Besins. Patrick Mark has received honoraria from Pfizer, AstraZeneca, Novartis, Bristol Myers Squibb, Napp, Vifor and Pharmacosmos and research support from Boehringer Ingelheim outside this work. Damian Fogarty has received honoraria for delivering educational meetings and/or attending advisory boards from AstraZeneca, Sanofi, Vifor Pharmaceuticals and Baxter. He provides consultancy for adjudication of endpoint in RCTs to ACI. Andrew Frankel has received research grants, and he prepares educational materials and attends drug advisory boards for: Boehringer Ingelheim/Lilly Alliance, AstraZeneca, Novo Nordisk, Merck and Johnson & Johnson. Ana Pokrajac has received honoraria for attending and delivering non‐promotional educational meetings and advisory boards from Lilly, NovoNordisk and Boehringer Ingelheim. Peter Winocour has received honoraria for delivering educational meetings and/or attending advisory boards for AstraZeneca, Eli Lilly, Novo Nordisk, Sanofi, MSD, Janssen and Vifor Pharmaceuticals. Janaka Karalliedde has received honoraria for delivering educational meetings and/or attending advisory boards Boehringer Ingelheim, AstraZeneca, Sanofi, Janssen, Novo Nordisk. Research grants from: AstraZeneca, Sanofi Rosa M Montero no conflicts of interest to declare Adnan Sharif has received honoraria for delivering educational meetings and/or attending advisory boards for Boehringer Ingelheim/Lilly Alliance, Napp Pharmaceuticals, Novo Nordisk, Astellas, Sandoz and Atara Biotherapeutics. He currently has grant funding from Chiesi UK. Publisher Copyright: This article has been co-published with permission in The British Journal of Diabetes, published by ABCD and Diabetic Medicine. All rights reserved in respect of The British Journal of Diabetes, {\textcopyright} Association of British clinical Diabetologists, and in respect of Diabetic Medicine, {\textcopyright} Diabetes UK. The articles are identical except for minor stylistic and spelling differences in keeping with each journal{\textquoteright}s style. Either citation can be used when citing this article. Funding Information: Stephen Bain has received honoraria, teaching and research sponsorship/grants from: Abbott, AstraZeneca, Boehringer Ingelheim, Eli Lilly, Merck Sharp & Dohme, Novo Nordisk, Roche and Sanofi Aventis. He has also received funding for the development of educational programmes from: Elsevier, OmniaMed and Medscape. He is a partner in Glycosmedia, which carries sponsorship declared on its website. Debasish Banerjee was previously funded for research by the British Heart Foundation (BHF). He is funded by ESR AstraZeneca for clinical trials. He has received speaker fees from Vifor Pharma and AstraZeneca Tahseen Chowdhury declares no conflicts of interest. Dipesh Patel has received honoraria for advisory work and/or lecture fees from AstraZeneca, Boehinger Ingelheim Eli Lilly, MSD and Napp Pharmaceuticals, Novo Nordisk and Sanofi Indranil Dasgupta has previously received research grants from Medtronic and Daiichi Sankyo. He has been a member of advisory committees and received educational grants from AstraZeneca, Amgen, Sanofi, MSD, Pfizer, GSK, Mitsubishi Pharma, Otsuka, Vifor Pharmaceuticals, Fresenius and Roche. Parijat De has received honoraria for educational meetings from AstraZeneca, Janssen, Boehringer Ingelheim, Novo, Sanofi, Novartis, Abbott, MSD, Takeda, Roche, Lilly, Ascensia, BD, Internis, GSK, Menarini, Bayer and Besins. Patrick Mark has received honoraria from Pfizer, AstraZeneca, Novartis, Bristol Myers Squibb, Napp, Vifor and Pharmacosmos and research support from Boehringer Ingelheim outside this work. Damian Fogarty has received honoraria for delivering educational meetings and/or attending advisory boards from AstraZeneca, Sanofi, Vifor Pharmaceuticals and Baxter. He provides consultancy for adjudication of endpoint in RCTs to ACI. Andrew Frankel has received research grants, and he prepares educational materials and attends drug advisory boards for: Boehringer Ingelheim/Lilly Alliance, AstraZeneca, Novo Nordisk, Merck and Johnson & Johnson. Ana Pokrajac has received honoraria for attending and delivering non‐promotional educational meetings and advisory boards from Lilly, NovoNordisk and Boehringer Ingelheim. Peter Winocour has received honoraria for delivering educational meetings and/or attending advisory boards for AstraZeneca, Eli Lilly, Novo Nordisk, Sanofi, MSD, Janssen and Vifor Pharmaceuticals. Janaka Karalliedde has received honoraria for delivering educational meetings and/or attending advisory boards Boehringer Ingelheim, AstraZeneca, Sanofi, Janssen, Novo Nordisk. Research grants from: AstraZeneca, Sanofi Rosa M Montero no conflicts of interest to declare Adnan Sharif has received honoraria for delivering educational meetings and/or attending advisory boards for Boehringer Ingelheim/Lilly Alliance, Napp Pharmaceuticals, Novo Nordisk, Astellas, Sandoz and Atara Biotherapeutics. He currently has grant funding from Chiesi UK. Publisher Copyright: This article has been co-published with permission in The British Journal of Diabetes, published by ABCD and Diabetic Medicine. All rights reserved in respect of The British Journal of Diabetes, {\textcopyright} 2022 Association of British clinical Diabetologists, and in respect of Diabetic Medicine, {\textcopyright} 2022 Diabetes UK. The articles are identical except for minor stylistic and spelling differences in keeping with each journal's style. Either citation can be used when citing this article.",
year = "2022",
month = apr,
doi = "10.1111/dme.14769",
language = "English",
volume = "39",
journal = "Diabetic Medicine",
issn = "0742-3071",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "4",
}
