TY - JOUR
T1 - Coronary Microcirculation in Aortic Stenosis
T2 - A Physiological Hornets' Nest
AU - McConkey, Hannah Z.R.
AU - Marber, Michael
AU - Chiribiri, Amedeo
AU - Pibarot, Philippe
AU - Redwood, Simon R.
AU - Prendergast, Bernard D.
PY - 2019/8/16
Y1 - 2019/8/16
N2 - Aortic stenosis is a heterogeneous disorder. Variations in the pathological and physiological responses to pressure overload are incompletely understood and generate a range of flow and pressure gradient patterns, which ultimately cause varying microvascular effects. The impact of cardiac-coronary coupling depends on these pressure and flow effects. In this article, we explore important concepts concerning cardiac physiology and the coronary microcirculation in aortic stenosis and their impact on myocardial remodeling, aortic valve flow patterns, and clinical progression.
AB - Aortic stenosis is a heterogeneous disorder. Variations in the pathological and physiological responses to pressure overload are incompletely understood and generate a range of flow and pressure gradient patterns, which ultimately cause varying microvascular effects. The impact of cardiac-coronary coupling depends on these pressure and flow effects. In this article, we explore important concepts concerning cardiac physiology and the coronary microcirculation in aortic stenosis and their impact on myocardial remodeling, aortic valve flow patterns, and clinical progression.
UR - http://www.scopus.com/inward/record.url?scp=85071539740&partnerID=8YFLogxK
U2 - 10.1161/CIRCINTERVENTIONS.118.007547
DO - 10.1161/CIRCINTERVENTIONS.118.007547
M3 - Review article
C2 - 31416359
AN - SCOPUS:85071539740
SN - 1941-7640
VL - 12
SP - e007547
JO - Circulation. Cardiovascular interventions
JF - Circulation. Cardiovascular interventions
IS - 8
M1 - e007547
ER -