Cortical and subcortical glutathione levels in adults with autism spectrum disorder

Alice M. S. Durieux; Jamie Horder; M. Andreina Hernandez; Alice Egerton; Steven C. R. Williams; C. Ellie Wilson; Deborah Spain; Clodagh Murphy; Dene Robertson; Gareth John Barker; Declan G Murphy; Grainne M McAlonan

doi:10.1002/aur.1522

Cortical and subcortical glutathione levels in adults with autism spectrum disorder

Alice M. S. Durieux, Jamie Horder, M. Andreina Hernandez, Alice Egerton, Steven C. R. Williams, C. Ellie Wilson, Deborah Spain, Clodagh Murphy, Dene Robertson, Gareth John Barker, Declan G Murphy, Grainne M McAlonan

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Abstract

Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men.

Original language	English
Number of pages	7
Journal	Autism research
Early online date	20 Aug 2015
DOIs	https://doi.org/10.1002/aur.1522
Publication status	E-pub ahead of print - 20 Aug 2015

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10.1002/aur.1522Licence: CC BY-NC-ND

Cortical and subcortical glutathione levels_DURIEUX Accepted 13Jul2015 GOLD VoRFinal published version, 232 KBLicence: CC BY

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title = "Cortical and subcortical glutathione levels in adults with autism spectrum disorder",

abstract = "Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men. ",

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T1 - Cortical and subcortical glutathione levels in adults with autism spectrum disorder

AU - Durieux, Alice M. S.

AU - Horder, Jamie

AU - Hernandez, M. Andreina

AU - Egerton, Alice

AU - Williams, Steven C. R.

AU - Wilson, C. Ellie

AU - Spain, Deborah

AU - Murphy, Clodagh

AU - Robertson, Dene

AU - Barker, Gareth John

AU - Murphy, Declan G

AU - McAlonan, Grainne M

PY - 2015/8/20

Y1 - 2015/8/20

N2 - Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men.

AB - Increased oxidative stress has been postulated to contribute to the pathogenesis of autism spectrum disorder (ASD). However, reports of alterations in oxidation markers including glutathione (GSH), the major endogenous antioxidant, are indirect, coming from blood plasma level measurements and postmortem studies. Therefore we used in-vivo 3 Tesla proton magnetic resonance spectroscopy ([1H]MRS) to directly measure GSH concentrations in the basal ganglia (BG) and the dorsomedial prefrontal cortex of 21 normally intelligent adult males with ASD and 29 controls who did not differ in age or IQ. There was no difference in brain GSH between patients and controls in either brain area; neither did GSH levels correlate with measures of clinical severity in patients. Thus [1H]MRS measures of cortical and subcortical GSH are not a biomarker for ASD in intellectually able adult men.

UR - http://www.ncbi.nlm.nih.gov/pubmed/26290215?dopt=Abstract

U2 - 10.1002/aur.1522

DO - 10.1002/aur.1522

M3 - Article

C2 - 26290215

SN - 1939-3792

JO - Autism research

JF - Autism research

ER -

Cortical and subcortical glutathione levels in adults with autism spectrum disorder

Abstract

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