Doping in sport: 3. Metabolic conversion of oral norethisterone to urinary 19-norandrosterone

Christopher J. Walker; David A. Cowan; Vivian H. T. James; Joanne C. Y. Lau; Andrew T. Kicman

doi:10.1016/j.steroids.2008.11.008

Doping in sport: 3. Metabolic conversion of oral norethisterone to urinary 19-norandrosterone

Christopher J. Walker, David A. Cowan, Vivian H. T. James, Joanne C. Y. Lau, Andrew T. Kicman

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13 Citations (Scopus)

Abstract

The detection of 19 norandrosterone (19-NA) in a competitor's urine sample is taken as prima facie evidence of administration of nandrolone or other 19-norsteroid but a potential problem is that administration of norethisterone, a progestogen used for menstrual disorders and for hormonal contraception, also results in the excretion of 19-NA that can exceed the laboratory reporting threshold of 2 ng/mL The contribution of norethisterone to urinary 19-NA with and without 19-norandrostenedione. a known norethisterone tablet impurity, requires evaluation. Preparations containing, either

Original language	English
Pages (from-to)	341 - 349
Number of pages	9
Journal	Steroids
Volume	74
Issue number	3
DOIs	https://doi.org/10.1016/j.steroids.2008.11.008
Publication status	Published - Mar 2009

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abstract = "The detection of 19 norandrosterone (19-NA) in a competitor's urine sample is taken as prima facie evidence of administration of nandrolone or other 19-norsteroid but a potential problem is that administration of norethisterone, a progestogen used for menstrual disorders and for hormonal contraception, also results in the excretion of 19-NA that can exceed the laboratory reporting threshold of 2 ng/mL The contribution of norethisterone to urinary 19-NA with and without 19-norandrostenedione. a known norethisterone tablet impurity, requires evaluation. Preparations containing, either ",

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AU - Walker, Christopher J.

AU - Cowan, David A.

AU - James, Vivian H. T.

AU - Lau, Joanne C. Y.

AU - Kicman, Andrew T.

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AB - The detection of 19 norandrosterone (19-NA) in a competitor's urine sample is taken as prima facie evidence of administration of nandrolone or other 19-norsteroid but a potential problem is that administration of norethisterone, a progestogen used for menstrual disorders and for hormonal contraception, also results in the excretion of 19-NA that can exceed the laboratory reporting threshold of 2 ng/mL The contribution of norethisterone to urinary 19-NA with and without 19-norandrostenedione. a known norethisterone tablet impurity, requires evaluation. Preparations containing, either

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DO - 10.1016/j.steroids.2008.11.008

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SP - 341

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JO - Steroids

JF - Steroids

IS - 3

ER -

Doping in sport: 3. Metabolic conversion of oral norethisterone to urinary 19-norandrosterone

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