Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on "system to system" mode

Qiong-Lin Liang; Xiao-Ping Liang; Yi-Ming Wang; Yuan-Yuan Xie; Rong-Li Zhang; Xi Chen; Rong Gao; Yi-Jun Cheng; Jun Wu; Qing-Bo Xu; Qing-Zhong Xiao; Xue Li; Shu-Feng Lv; Xue-Mei Fan; Hong-Yang Zhang; Qing-Li Zhang; Guo-An Luo

Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on "system to system" mode

Qiong-Lin Liang, Xiao-Ping Liang, Yi-Ming Wang, Yuan-Yuan Xie, Rong-Li Zhang, Xi Chen, Rong Gao, Yi-Jun Cheng, Jun Wu, Qing-Bo Xu, Qing-Zhong Xiao, Xue Li, Shu-Feng Lv, Xue-Mei Fan, Hong-Yang Zhang, Qing-Li Zhang, Guo-An Luo

Cardiovascular Sciences

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Background: Shuanglong formula (SLF), a Chinese medicine composed of panax ginseng and salvia miltiorrhiza exhibited significant effect in the treatment of myocardial infarction (MI) in clinical. Because of the complex nature and lack of stringent quality control, it's difficult to explain the action mechanism of SLF. Method: In this study, we present a "system to system" (S2S) mode. Based on this mode, SLF was simplified successively through bioactivity-guided screening to achieve an optimized minimal phytochemical composition (new formula NSLF6) while maintaining its curative effect for MI. Results: Pharmacological test combining with the study of systems biology show that NSLF6 has activity for treatment MI through synergistic therapeutic efficacies between total ginsenosides and total salvianolic acids via promoting cardiac cell regeneration and myocardial angiogenesis, antagonistic myocardial cell oxidative damage. Conclusions: The present S2S mode may be an effective way for the discovery of new composite drugs from traditional medicines.

Original language	English
Article number	26
Journal	Journal Of Translational Medicine
Volume	10
Issue number	1
Publication status	Published - 8 Feb 2012

Cite this

Liang, Q.-L., Liang, X.-P., Wang, Y.-M., Xie, Y.-Y., Zhang, R.-L., Chen, X., Gao, R., Cheng, Y.-J., Wu, J., Xu, Q.-B., Xiao, Q.-Z., Li, X., Lv, S.-F., Fan, X.-M., Zhang, H.-Y., Zhang, Q.-L., & Luo, G.-A. (2012). Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on "system to system" mode. Journal Of Translational Medicine, 10(1), Article 26.

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title = "Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on {"}system to system{"} mode",

abstract = "Background: Shuanglong formula (SLF), a Chinese medicine composed of panax ginseng and salvia miltiorrhiza exhibited significant effect in the treatment of myocardial infarction (MI) in clinical. Because of the complex nature and lack of stringent quality control, it's difficult to explain the action mechanism of SLF. Method: In this study, we present a {"}system to system{"} (S2S) mode. Based on this mode, SLF was simplified successively through bioactivity-guided screening to achieve an optimized minimal phytochemical composition (new formula NSLF6) while maintaining its curative effect for MI. Results: Pharmacological test combining with the study of systems biology show that NSLF6 has activity for treatment MI through synergistic therapeutic efficacies between total ginsenosides and total salvianolic acids via promoting cardiac cell regeneration and myocardial angiogenesis, antagonistic myocardial cell oxidative damage. Conclusions: The present S2S mode may be an effective way for the discovery of new composite drugs from traditional medicines.",

author = "Qiong-Lin Liang and Xiao-Ping Liang and Yi-Ming Wang and Yuan-Yuan Xie and Rong-Li Zhang and Xi Chen and Rong Gao and Yi-Jun Cheng and Jun Wu and Qing-Bo Xu and Qing-Zhong Xiao and Xue Li and Shu-Feng Lv and Xue-Mei Fan and Hong-Yang Zhang and Qing-Li Zhang and Guo-An Luo",

year = "2012",

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day = "8",

language = "English",

volume = "10",

journal = "Journal Of Translational Medicine",

publisher = "BioMed Central",

number = "1",

}

Liang, Q-L, Liang, X-P, Wang, Y-M, Xie, Y-Y, Zhang, R-L, Chen, X, Gao, R, Cheng, Y-J, Wu, J, Xu, Q-B , Xiao, Q-Z, Li, X, Lv, S-F, Fan, X-M, Zhang, H-Y, Zhang, Q-L & Luo, G-A 2012, 'Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on "system to system" mode', Journal Of Translational Medicine, vol. 10, no. 1, 26.

TY - JOUR

T1 - Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on "system to system" mode

AU - Liang, Qiong-Lin

AU - Liang, Xiao-Ping

AU - Wang, Yi-Ming

AU - Xie, Yuan-Yuan

AU - Zhang, Rong-Li

AU - Chen, Xi

AU - Gao, Rong

AU - Cheng, Yi-Jun

AU - Wu, Jun

AU - Xu, Qing-Bo

AU - Xiao, Qing-Zhong

AU - Li, Xue

AU - Lv, Shu-Feng

AU - Fan, Xue-Mei

AU - Zhang, Hong-Yang

AU - Zhang, Qing-Li

AU - Luo, Guo-An

PY - 2012/2/8

Y1 - 2012/2/8

N2 - Background: Shuanglong formula (SLF), a Chinese medicine composed of panax ginseng and salvia miltiorrhiza exhibited significant effect in the treatment of myocardial infarction (MI) in clinical. Because of the complex nature and lack of stringent quality control, it's difficult to explain the action mechanism of SLF. Method: In this study, we present a "system to system" (S2S) mode. Based on this mode, SLF was simplified successively through bioactivity-guided screening to achieve an optimized minimal phytochemical composition (new formula NSLF6) while maintaining its curative effect for MI. Results: Pharmacological test combining with the study of systems biology show that NSLF6 has activity for treatment MI through synergistic therapeutic efficacies between total ginsenosides and total salvianolic acids via promoting cardiac cell regeneration and myocardial angiogenesis, antagonistic myocardial cell oxidative damage. Conclusions: The present S2S mode may be an effective way for the discovery of new composite drugs from traditional medicines.

AB - Background: Shuanglong formula (SLF), a Chinese medicine composed of panax ginseng and salvia miltiorrhiza exhibited significant effect in the treatment of myocardial infarction (MI) in clinical. Because of the complex nature and lack of stringent quality control, it's difficult to explain the action mechanism of SLF. Method: In this study, we present a "system to system" (S2S) mode. Based on this mode, SLF was simplified successively through bioactivity-guided screening to achieve an optimized minimal phytochemical composition (new formula NSLF6) while maintaining its curative effect for MI. Results: Pharmacological test combining with the study of systems biology show that NSLF6 has activity for treatment MI through synergistic therapeutic efficacies between total ginsenosides and total salvianolic acids via promoting cardiac cell regeneration and myocardial angiogenesis, antagonistic myocardial cell oxidative damage. Conclusions: The present S2S mode may be an effective way for the discovery of new composite drugs from traditional medicines.

M3 - Article

VL - 10

JO - Journal Of Translational Medicine

JF - Journal Of Translational Medicine

IS - 1

M1 - 26

ER -

Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on "system to system" mode

Abstract

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