EphB receptors and ephrin-B ligands regulate spinal sensory connectivity and modulate pain processing

A A Battaglia; K Sehayek; J Grist; S B McMahon; I Gavazzi

doi:10.1038/nn1034

EphB receptors and ephrin-B ligands regulate spinal sensory connectivity and modulate pain processing

A A Battaglia, K Sehayek, J Grist, S B McMahon, I Gavazzi

Research output: Contribution to journal › Article › peer-review

108 Citations (Scopus)

Abstract

Eph receptor tyrosine kinases and their ephrin ligands are involved in crucial aspects of nervous system circuit assembly during development1, 2, but their functional roles in the mature nervous system are poorly understood. We investigated their role in pain processing, using a combination of immunohistochemical, behavioral, biochemical and primary cell culture techniques. Here we report an in vivo role for EphB−ephrinB interactions as modulators of synaptic efficacy in the spinal cord, contributing to sensory abnormalities in persistent pain states.

Original language	English
Pages (from-to)	339 - 340
Number of pages	2
Journal	Nature Neuroscience
Volume	6
Issue number	4
DOIs	https://doi.org/10.1038/nn1034
Publication status	Published - 1 Apr 2003

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EphB receptors and ephrin-B ligands regulate spinal sensory connectivity and modulate pain processing

Abstract

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