Abstract
OBJECTIVE: We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth.
RESEARCH DESIGN AND METHODS: We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibodypositive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sex and age-specific ceBMI thresholds for greatest type 1 diabetes risk.
RESULTS: Higher ceBMI conferred significantly greater risk of progressing to type 1 diabetes. The increased diabetes risk occurred at lower ceBMI values in children <12 years of age compared with older subjects and in females versus males.
CONCLUSIONS: Elevated BMI is associated with increased risk of diabetes progression in pediatric autoantibody-positive relatives, but the effect varies by sex and age.
| Original language | English |
|---|---|
| Pages (from-to) | 698-701 |
| Journal | Diabetes Care |
| Volume | 40 |
| Issue number | 5 |
| Early online date | 20 Apr 2017 |
| DOIs | |
| Publication status | Published - 1 May 2017 |
Access to Document
- Excess body mass index_FERRARA_Publishedonline20April2017_GREEN AAM
This is the peer-reviewed accepted manuscript of an article published in Diabetes Care, v. 40, issue 5 (American Diabetes Association, May 2017). The final published version is available via https://doi.org/10.2337/dc16-2331 This is an author-created, uncopyedited electronic version of an article accepted for publication in Diabetes Care. The American Diabetes Association (ADA), publisher of Diabetes Care, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future issue of Diabetes Care in print and online at URL: http://care.diabetesjournals.org.