Genome-wide expression profile of sporadic gastric cancers with microsatellite instability

Mariarosaria D'Errico; Emanuele de Rinaldis; Monica F Blasi; Valentina Viti; Mario Falchetti; Angelo Calcagnile; Francesco Sera; Calogero Saieva; Laura Ottini; Domenico Palli; Fabio Palombo; Alessandro Giuliani; Eugenia Dogliotti

doi:10.1016/j.ejca.2008.10.032

Genome-wide expression profile of sporadic gastric cancers with microsatellite instability

Mariarosaria D'Errico, Emanuele de Rinaldis, Monica F Blasi, Valentina Viti, Mario Falchetti, Angelo Calcagnile, Francesco Sera, Calogero Saieva, Laura Ottini, Domenico Palli, Fabio Palombo, Alessandro Giuliani, Eugenia Dogliotti

Research output: Contribution to journal › Article › peer-review

279 Citations (Scopus)

Abstract

Gastric cancers with mismatch repair (MMR) inactivation are characterised by microsatellite instability (MSI). In this study, the transcriptional profile of 38 gastric cancers with and without MSI was analysed. Unsupervised analysis showed that the immune and apoptotic gene networks efficiently discriminated these two cancer types. Hierarchical clustering analysis revealed numerous gene expression changes associated with the MSI phenotype. Amongst these, the p53-responsive genes maspin and 14-3-3 sigma were significantly more expressed in tumours with than without MSI. A tight immunosurveillance coupled with a functional p53 gene response is consistent with the better prognosis of MSI cancers. Frequent silencing of MLH1 and downregulation of MMR target genes, such as MRE11 and MBD4, characterised MSI tumours. The downregulation of SMUG1 was also a typical feature of these tumours. The DNA repair gene expression profile of gastric cancer with MSI is of relevance for therapy response.

Original language	English
Pages (from-to)	461-469
Number of pages	9
Journal	European Journal of Cancer
Volume	45
Issue number	3
Early online date	8 Dec 2008
DOIs	https://doi.org/10.1016/j.ejca.2008.10.032
Publication status	Published - Feb 2009

Keywords

Aged
Aged, 80 and over
DNA Mismatch Repair
Down-Regulation
Female
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genes, p53
Humans
Male
Microsatellite Instability
Middle Aged
Oligonucleotide Array Sequence Analysis
Phenotype
Prognosis
Promoter Regions, Genetic
Stomach Neoplasms

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejca.2008.10.032

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title = "Genome-wide expression profile of sporadic gastric cancers with microsatellite instability",

abstract = "Gastric cancers with mismatch repair (MMR) inactivation are characterised by microsatellite instability (MSI). In this study, the transcriptional profile of 38 gastric cancers with and without MSI was analysed. Unsupervised analysis showed that the immune and apoptotic gene networks efficiently discriminated these two cancer types. Hierarchical clustering analysis revealed numerous gene expression changes associated with the MSI phenotype. Amongst these, the p53-responsive genes maspin and 14-3-3 sigma were significantly more expressed in tumours with than without MSI. A tight immunosurveillance coupled with a functional p53 gene response is consistent with the better prognosis of MSI cancers. Frequent silencing of MLH1 and downregulation of MMR target genes, such as MRE11 and MBD4, characterised MSI tumours. The downregulation of SMUG1 was also a typical feature of these tumours. The DNA repair gene expression profile of gastric cancer with MSI is of relevance for therapy response.",

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author = "Mariarosaria D'Errico and {de Rinaldis}, Emanuele and Blasi, {Monica F} and Valentina Viti and Mario Falchetti and Angelo Calcagnile and Francesco Sera and Calogero Saieva and Laura Ottini and Domenico Palli and Fabio Palombo and Alessandro Giuliani and Eugenia Dogliotti",

year = "2009",

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doi = "10.1016/j.ejca.2008.10.032",

language = "English",

volume = "45",

pages = "461--469",

journal = "European Journal of Cancer",

issn = "1879-0852",

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T1 - Genome-wide expression profile of sporadic gastric cancers with microsatellite instability

AU - D'Errico, Mariarosaria

AU - de Rinaldis, Emanuele

AU - Blasi, Monica F

AU - Viti, Valentina

AU - Falchetti, Mario

AU - Calcagnile, Angelo

AU - Sera, Francesco

AU - Saieva, Calogero

AU - Ottini, Laura

AU - Palli, Domenico

AU - Palombo, Fabio

AU - Giuliani, Alessandro

AU - Dogliotti, Eugenia

PY - 2009/2

Y1 - 2009/2

N2 - Gastric cancers with mismatch repair (MMR) inactivation are characterised by microsatellite instability (MSI). In this study, the transcriptional profile of 38 gastric cancers with and without MSI was analysed. Unsupervised analysis showed that the immune and apoptotic gene networks efficiently discriminated these two cancer types. Hierarchical clustering analysis revealed numerous gene expression changes associated with the MSI phenotype. Amongst these, the p53-responsive genes maspin and 14-3-3 sigma were significantly more expressed in tumours with than without MSI. A tight immunosurveillance coupled with a functional p53 gene response is consistent with the better prognosis of MSI cancers. Frequent silencing of MLH1 and downregulation of MMR target genes, such as MRE11 and MBD4, characterised MSI tumours. The downregulation of SMUG1 was also a typical feature of these tumours. The DNA repair gene expression profile of gastric cancer with MSI is of relevance for therapy response.

AB - Gastric cancers with mismatch repair (MMR) inactivation are characterised by microsatellite instability (MSI). In this study, the transcriptional profile of 38 gastric cancers with and without MSI was analysed. Unsupervised analysis showed that the immune and apoptotic gene networks efficiently discriminated these two cancer types. Hierarchical clustering analysis revealed numerous gene expression changes associated with the MSI phenotype. Amongst these, the p53-responsive genes maspin and 14-3-3 sigma were significantly more expressed in tumours with than without MSI. A tight immunosurveillance coupled with a functional p53 gene response is consistent with the better prognosis of MSI cancers. Frequent silencing of MLH1 and downregulation of MMR target genes, such as MRE11 and MBD4, characterised MSI tumours. The downregulation of SMUG1 was also a typical feature of these tumours. The DNA repair gene expression profile of gastric cancer with MSI is of relevance for therapy response.

KW - Aged

KW - Aged, 80 and over

KW - DNA Mismatch Repair

KW - Down-Regulation

KW - Female

KW - Gene Expression Profiling

KW - Gene Expression Regulation, Neoplastic

KW - Genes, p53

KW - Humans

KW - Male

KW - Microsatellite Instability

KW - Middle Aged

KW - Oligonucleotide Array Sequence Analysis

KW - Phenotype

KW - Prognosis

KW - Promoter Regions, Genetic

KW - Stomach Neoplasms

U2 - 10.1016/j.ejca.2008.10.032

DO - 10.1016/j.ejca.2008.10.032

M3 - Article

C2 - 19081245

SN - 1879-0852

VL - 45

SP - 461

EP - 469

JO - European Journal of Cancer

JF - European Journal of Cancer

IS - 3

ER -

Genome-wide expression profile of sporadic gastric cancers with microsatellite instability

Abstract

Keywords

UN SDGs

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