TY - JOUR
T1 - Grey matter volume differences associated with extremely low levels of cannabis use in adolescence
AU - Orr, Catherine
AU - Spechler, Philip
AU - Cao, Zhipeng
AU - Albaugh, Matthew
AU - Chaarani, Bader
AU - Mackey, Scott
AU - D’Souza, Deepak
AU - Allgaier, Nicholas
AU - Banaschewski, Tobias
AU - Bokde, Arun L.W.
AU - Bromberg, Uli
AU - Büchel, Christian
AU - Quinlan, Erin Burke
AU - Conrod, Patricia
AU - Desrivières, Sylvane
AU - Flor, Herta
AU - Frouin, Vincent
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Ittermann, Bernd
AU - Martinot, Jean Luc
AU - Martinot, Marie Laure Paillère
AU - Nees, Frauke
AU - Orfanos, Dimitri Papadopoulos
AU - Paus, Tomáš
AU - Poustka, Luise
AU - Millenet, Sabina
AU - Fröhner, Juliane H.
AU - Radhakrishnan, Rajiv
AU - Smolka, Michael N.
AU - Walter, Henrik
AU - Whelan, Robert
AU - Schumann, Gunter
AU - Potter, Alexandra
AU - Garavan, Hugh
PY - 2019/3/6
Y1 - 2019/3/6
N2 - Rates of cannabis use among adolescents are high, and are increasing concurrent with changes in the legal status of marijuana and societal attitudes regarding its use. Recreational cannabis use is understudied, especially in the adolescent period when neural maturation may make users particularly vulnerable to the effects of Δ-9-tetrahydrocannabinol (THC) on brain structure. In the current study, we used voxel-based morphometry to compare gray matter volume (GMV) in forty-six 14-year-old human adolescents (males and females) with just one or two instances of cannabis use and carefully matched THC-naive controls. We identified extensive regions in the bilateral medial temporal lobes as well as the bilateral posterior cingulate, lingual gyri, and cerebellum that showed greater GMV in the cannabis users. Analysis of longitudinal data confirmed that GMV differences were unlikely to precede cannabis use. GMV in the temporal regions was associated with contemporaneous performance on the Perceptual Reasoning Index and with future generalized anxiety symptoms in the cannabis users. The distribution of GMV effects mapped onto biomarkers of the endogenous cannabinoid system providing insight into possible mechanisms for these effects.
AB - Rates of cannabis use among adolescents are high, and are increasing concurrent with changes in the legal status of marijuana and societal attitudes regarding its use. Recreational cannabis use is understudied, especially in the adolescent period when neural maturation may make users particularly vulnerable to the effects of Δ-9-tetrahydrocannabinol (THC) on brain structure. In the current study, we used voxel-based morphometry to compare gray matter volume (GMV) in forty-six 14-year-old human adolescents (males and females) with just one or two instances of cannabis use and carefully matched THC-naive controls. We identified extensive regions in the bilateral medial temporal lobes as well as the bilateral posterior cingulate, lingual gyri, and cerebellum that showed greater GMV in the cannabis users. Analysis of longitudinal data confirmed that GMV differences were unlikely to precede cannabis use. GMV in the temporal regions was associated with contemporaneous performance on the Perceptual Reasoning Index and with future generalized anxiety symptoms in the cannabis users. The distribution of GMV effects mapped onto biomarkers of the endogenous cannabinoid system providing insight into possible mechanisms for these effects.
KW - Adolescent substance use
KW - Cannabis
KW - Cognition
KW - Marijuana
KW - Psychopathology
KW - Voxel-based morphometry
UR - http://www.scopus.com/inward/record.url?scp=85062588180&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.3375-17.2018
DO - 10.1523/JNEUROSCI.3375-17.2018
M3 - Article
C2 - 30643026
AN - SCOPUS:85062588180
SN - 0270-6474
VL - 39
SP - 1817
EP - 1827
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 10
ER -