Gut microbiota associations with common diseases and prescription medications in a population-based cohort

Matthew A. Jackson; Serena Verdi; Maria-Emanuela Maxan; Cheol Min Shin; Jonas Zierer; Ruth C. E. Bowyer; Tiphaine Martin; Frances Williams; Cristina Menni; Jordana T. Bell; Tim D. Spector; Claire J. Steves

doi:10.1038/s41467-018-05184-7

Gut microbiota associations with common diseases and prescription medications in a population-based cohort

Matthew A. Jackson, Serena Verdi, Maria-Emanuela Maxan, Cheol Min Shin, Jonas Zierer, Ruth C. E. Bowyer, Tiphaine Martin, Frances Williams, Cristina Menni, Jordana T. Bell, Tim D. Spector, Claire J. Steves

Twin Research & Genetic Epidemiology

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Abstract

The human gut microbiome has been associated with many health factors but variability between studies limits exploration of effects between them. Gut microbiota profiles are available for >2700 members of the deeply phenotyped TwinsUK cohort, providing a uniform platform for such comparisons. Here, we present gut microbiota association analyses for 38 common diseases and 51 medications within the cohort. We describe several novel associations, highlight associations common across multiple diseases, and determine which diseases and medications have the greatest association with the gut microbiota. These results provide a reference for future studies of the gut microbiome and its role in human health.

Original language	English
Article number	2655
Number of pages	8
Journal	Nature Communications
Volume	9
Issue number	1
Early online date	9 Jul 2018
DOIs	https://doi.org/10.1038/s41467-018-05184-7
Publication status	E-pub ahead of print - 9 Jul 2018

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Gut microbiota associations_WILLIAMS_Accepted18June2018_GOLD AAM CC BYAccepted author manuscript, 194 KBLicence: CC BY
Gut microbiota associations_WILLIAMS_Accepted18June2018_GOLD VoR CC BYFinal published version, 714 KBLicence: CC BY

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Jackson, M. A., Verdi, S., Maxan, M.-E., Min Shin, C., Zierer, J., Bowyer, R. C. E., Martin, T., Williams, F., Menni, C., Bell, J. T., Spector, T. D., & Steves, C. J. (2018). Gut microbiota associations with common diseases and prescription medications in a population-based cohort. Nature Communications, 9(1), Article 2655. Advance online publication. https://doi.org/10.1038/s41467-018-05184-7

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abstract = "The human gut microbiome has been associated with many health factors but variability between studies limits exploration of effects between them. Gut microbiota profiles are available for >2700 members of the deeply phenotyped TwinsUK cohort, providing a uniform platform for such comparisons. Here, we present gut microbiota association analyses for 38 common diseases and 51 medications within the cohort. We describe several novel associations, highlight associations common across multiple diseases, and determine which diseases and medications have the greatest association with the gut microbiota. These results provide a reference for future studies of the gut microbiome and its role in human health.",

author = "Jackson, {Matthew A.} and Serena Verdi and Maria-Emanuela Maxan and {Min Shin}, Cheol and Jonas Zierer and Bowyer, {Ruth C. E.} and Tiphaine Martin and Frances Williams and Cristina Menni and Bell, {Jordana T.} and Spector, {Tim D.} and Steves, {Claire J.}",

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AU - Jackson, Matthew A.

AU - Verdi, Serena

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AU - Zierer, Jonas

AU - Bowyer, Ruth C. E.

AU - Martin, Tiphaine

AU - Williams, Frances

AU - Menni, Cristina

AU - Bell, Jordana T.

AU - Spector, Tim D.

AU - Steves, Claire J.

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AB - The human gut microbiome has been associated with many health factors but variability between studies limits exploration of effects between them. Gut microbiota profiles are available for >2700 members of the deeply phenotyped TwinsUK cohort, providing a uniform platform for such comparisons. Here, we present gut microbiota association analyses for 38 common diseases and 51 medications within the cohort. We describe several novel associations, highlight associations common across multiple diseases, and determine which diseases and medications have the greatest association with the gut microbiota. These results provide a reference for future studies of the gut microbiome and its role in human health.

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JO - Nature Communications

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Gut microbiota associations with common diseases and prescription medications in a population-based cohort

Abstract

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