Harnessing dendritic cells in inflammatory skin diseases

Chung-Ching Chu; Paola Di Meglio; Frank O. Nestle

doi:10.1016/j.smim.2011.01.006

Harnessing dendritic cells in inflammatory skin diseases

Chung-Ching Chu, Paola Di Meglio, Frank O. Nestle

Dermatology

Research output: Contribution to journal › Literature review › peer-review

77 Citations (Scopus)

Abstract

The skin immune system harbors a complex network of dendritic cells (DCs). Recent studies highlight a diverse functional specialization of skin DC subsets. In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms to ensure the maintenance of immune homeostasis, as well as in pathogenesis of chronic inflammation in the skin when excessive immune responses are initiated and unrestrained. Harnessing DCs by directly targeting DC-derived molecules or selectively modulate DC subsets is a convincing strategy to tackle inflammatory skin diseases. In this review we discuss recent advances underlining the functional specialization of skin DCs and discuss the potential implication for future DC-based therapeutic strategies. (C) 2011 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	28 - 41
Number of pages	14
Journal	Seminars in Immunology
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.smim.2011.01.006
Publication status	Published - Feb 2011

Access to Document

10.1016/j.smim.2011.01.006

Cite this

@article{206842f83a5e4993b1309dca9a603460,

title = "Harnessing dendritic cells in inflammatory skin diseases",

abstract = "The skin immune system harbors a complex network of dendritic cells (DCs). Recent studies highlight a diverse functional specialization of skin DC subsets. In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms to ensure the maintenance of immune homeostasis, as well as in pathogenesis of chronic inflammation in the skin when excessive immune responses are initiated and unrestrained. Harnessing DCs by directly targeting DC-derived molecules or selectively modulate DC subsets is a convincing strategy to tackle inflammatory skin diseases. In this review we discuss recent advances underlining the functional specialization of skin DCs and discuss the potential implication for future DC-based therapeutic strategies. (C) 2011 Elsevier Ltd. All rights reserved.",

author = "Chung-Ching Chu and {Di Meglio}, Paola and Nestle, {Frank O.}",

year = "2011",

month = feb,

doi = "10.1016/j.smim.2011.01.006",

language = "English",

volume = "23",

pages = "28 -- 41",

journal = "Seminars in Immunology",

publisher = "ACADEMIC PRESS INC",

number = "1",

}

TY - JOUR

T1 - Harnessing dendritic cells in inflammatory skin diseases

AU - Chu, Chung-Ching

AU - Di Meglio, Paola

AU - Nestle, Frank O.

PY - 2011/2

Y1 - 2011/2

N2 - The skin immune system harbors a complex network of dendritic cells (DCs). Recent studies highlight a diverse functional specialization of skin DC subsets. In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms to ensure the maintenance of immune homeostasis, as well as in pathogenesis of chronic inflammation in the skin when excessive immune responses are initiated and unrestrained. Harnessing DCs by directly targeting DC-derived molecules or selectively modulate DC subsets is a convincing strategy to tackle inflammatory skin diseases. In this review we discuss recent advances underlining the functional specialization of skin DCs and discuss the potential implication for future DC-based therapeutic strategies. (C) 2011 Elsevier Ltd. All rights reserved.

AB - The skin immune system harbors a complex network of dendritic cells (DCs). Recent studies highlight a diverse functional specialization of skin DC subsets. In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms to ensure the maintenance of immune homeostasis, as well as in pathogenesis of chronic inflammation in the skin when excessive immune responses are initiated and unrestrained. Harnessing DCs by directly targeting DC-derived molecules or selectively modulate DC subsets is a convincing strategy to tackle inflammatory skin diseases. In this review we discuss recent advances underlining the functional specialization of skin DCs and discuss the potential implication for future DC-based therapeutic strategies. (C) 2011 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.smim.2011.01.006

DO - 10.1016/j.smim.2011.01.006

M3 - Literature review

VL - 23

SP - 28

EP - 41

JO - Seminars in Immunology

JF - Seminars in Immunology

IS - 1

ER -

Harnessing dendritic cells in inflammatory skin diseases

Abstract

Access to Document

Fingerprint

Cite this