@inbook{2c301a595a9d4361ac4d00a7356f38c9,
title = "Harvesting biomolecules from tissue by porous silicon nanoneedles",
abstract = "Precision oncology is increasingly focusing on alternative strategies to tissue biopsy, for less invasive collection of biological samples containing optimal information for molecular diagnostics. Ordered arrays of porous-silicon nanoneedles (pSi-nNs) has the potential to harvest RNA, proteins and lipids from with lower invasiveness than tissue biopsy. We characterized the fabrication of nNs, to perform fine-tuning of their porosity and shape through metal-assisted chemical etching (MACE) and reactive ion etching (RIE). We interfaced nNs with tissue to evaluate the total yield of harvested biomolecules, finding an amount of RNA, proteins and lipids comparable with that extracted from a 30μm tissue section.",
keywords = "Molecular Diagnostics, Nanoneedles, Porous Silicon",
author = "Martella, {Davide A.} and Ciro Chiappini",
year = "2020",
language = "English",
series = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "1087--1088",
booktitle = "MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
note = "24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 ; Conference date: 04-10-2020 Through 09-10-2020",
}