Research output per year
Research output per year
Personal profile
Research interests (short)
Dr Chiappini investigates the biointerface blending nanotechnology, bioengineering and cell biology to develop functional materials that direct cell behaviour.
Research interests
Dr Chiappini investigates the biointerface blending nanotechnology, bioengineering and cell biology to develop functional materials that direct cell behaviour.
Dr. Chiappini current research focuses on developing mesoporous silicon nanomaterials for regenerative medicine and cancer. He has conceived and developed porous silicon nanoneedles, capable of intracellular interfacing leading to neovascularization in animal models. He is currently exploring the nanoneedle biointerface and developing them for intracellular drug delivery and sensing. Further research activity focuses novel multifunctional nanoparticles that combine therapeutics and imaging in cancer.
Biographical details
Dr. Chiappini is Lecturer in Nanomaterials and Biointerfaces in the Deparment of Craniofacial Development and Stem Cell Biology. Following a Ph.D. in Biomedical Engineering from the University of Texas at Austin in 2011, he joined Imperial College London as a and has been Newton International Fellow and later as a Marie Curie Fellow.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biomedical Engineering, Doctor of Philosophy, University of Texas at Austin
Award Date: 21 May 2011
Physics, Master of Science, University of Milan
Award Date: 20 Oct 2006
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Collaborations and top research areas from the last five years
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Integrating Porous Silicon Nanoneedles within Medical Devices for Nucleic Acid Nanoinjection
Wang, C., Gu, C., Popp, C., Vashisth, P., Mustfa, S. A., Martella, D. A., Spiteri, C., McLennan, S., Sun, N., Riddle, M., Eide, C. R., Parsons, M., Tolar, J., McGrath, J. A. & Chiappini, C., 11 Jun 2024, In: ACS Nano. 18, 23, p. 14938-14953 16 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
Lithiated porous silicon nanowires stimulate periodontal regeneration
Kaasalainen, M., Zhang, R., Vashisth, P., Ahmadi Birjandi, A., S'Ari, M., Martella, D., Isaacs, M., Makila, E., Wang, C., Moldenhauer, E., Clarke, P., Pinna, A., Zhang, X., Mustfa, S. A., Caprettini, V., Morrell, A., Gentleman, E., Brauer, D. S., Addison, O. & Zhang, X. & 7 others, , 12 Jan 2024, (E-pub ahead of print) In: Nature Communications. 15, 1, 487.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Spatially-Resolved Organoid Transfection by Porous Silicon-Mediated Optoporation
Spiteri, C., Caprettini, V., Wang, Y., Dominguez-Gil, S., Kaasalainen, M., Wang, C., Martella, D. A., McLennan, S., Vashisth, P., Gary-Bobo, M., Nguyen, C., Bergholt, M., Durand, J. O., Cunin, F. & Chiappini, C., 2024, (Accepted/In press) In: Advanced Materials.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
A method for reproducible high-resolution imaging of 3D cancer cell spheroids
Phillips, T., Caprettini, V., Aggarwal, N., Marcotti, S., Tetley, R., Mao, Y., Shaw, T., Chiappini, C., Parsons, M. & Cox, S., Jul 2023, In: Journal of Microscopy. 291, 1, p. 30-42 13 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile5 Citations (Scopus)89 Downloads (Pure) -
CRISPR/Cas-Assisted Nanoneedle Sensor for Adenosine Triphosphate Detection in Living Cells
Kim, H., Gu, C., Mustfa, S. A., Martella, D. A., Wang, C., Wang, Y. & Chiappini, C., 1 Nov 2023, In: ACS Applied Materials and Interfaces. 15, 43, p. 49964-49973 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile11 Citations (Scopus)67 Downloads (Pure)
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Corneal nanoinjection: a nanoneedle platform for gene editing in inherited corneal endothelial disorders
Chiappini, C. (Primary Investigator)
29/09/2024 → 28/03/2027
Project: Research
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Prenatal ThERapy for SIckle CelL DisEaSe (PERICLES)
Shangaris, P. (Primary Investigator), Chiappini, C. (Co-Investigator), El Hoss, S. (Co-Investigator), Jackow, J. (Co-Investigator), Lombardi, G. (Co-Investigator) & Nicolaides, K. (Co-Investigator)
1/12/2023 → 30/11/2027
Project: Research
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Improved Characterization Of Chronic Wounds In RDEB
McGrath, J. (Primary Investigator), Bergholt, M. (Co-Investigator) & Chiappini, C. (Co-Investigator)
1/06/2022 → 31/07/2025
Project: Research
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Integrated multi-modal tissue state mapping of TNBC progression
Parsons, M. (Primary Investigator), Abbate, V. (Co-Investigator), Ameer-Beg, S. (Co-Investigator), Barber, P. (Co-Investigator), Bergholt, M. (Co-Investigator), Chan, A. (Co-Investigator), Chiappini, C. (Co-Investigator), Cox, S. (Co-Investigator), Gillett, C. (Co-Investigator), Grigoriadis, A. (Co-Investigator), Irshad, S. (Co-Investigator), Karimi, M. M. (Co-Investigator), Ng, T. (Co-Investigator), Ourselin, S. (Co-Investigator), Pinder, S. (Co-Investigator), Purushotham, A. (Co-Investigator), Sinkus, R. (Co-Investigator), Spencer, J. (Co-Investigator) & Stewart, T. (Co-Investigator)
30/09/2021 → 30/09/2025
Project: Research
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CosMX Spatial Molecular Imager
Chiappini, C. (Primary Investigator), Giacca, M. (Co-Investigator), Grigoriadis, A. (Co-Investigator), Lawrence, T. (Co-Investigator), Parsons, M. (Co-Investigator) & Spagnoli, F. (Co-Investigator)
1/10/2022 → 31/03/2023
Project: Research