IgG4 antibodies and cancer-associated inflammation: Insights into a novel mechanism of immune escape

Panagiotis Karagiannis; Amy E. Gilbert; Frank O. Nestle; Sophia N. Karagiannis

doi:10.4161/onci.24889

IgG4 antibodies and cancer-associated inflammation: Insights into a novel mechanism of immune escape

Panagiotis Karagiannis, Amy E. Gilbert, Frank O. Nestle, Sophia N. Karagiannis^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

The role of B cells and antibodies in cancer is insufficiently understood but is receiving increasing attention. We have recently identified IgG4 as an antibody subclass elicited by melanoma-associated interleukin-10-driven inflammation. In this setting, IgG4 exhibit inefficient immunostimulatory capacity and block the cytotoxic activities of other antibodies. These previously unappreciated mechanisms of immune escape may constitute promising targets for the development of novel anticancer immunotherapies.

Original language	English
Article number	e24889
Pages (from-to)	1-3
Number of pages	3
Journal	OncoImmunology
Volume	2
Issue number	7
DOIs	https://doi.org/10.4161/onci.24889
Publication status	Published - 1 Jul 2013

Keywords

Antibody effector functions
B cells
Cancer inflammation
FcVRI
IgG4
IL-10
Immune escape
Melanoma
VEGF

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/onci.24889

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abstract = "The role of B cells and antibodies in cancer is insufficiently understood but is receiving increasing attention. We have recently identified IgG4 as an antibody subclass elicited by melanoma-associated interleukin-10-driven inflammation. In this setting, IgG4 exhibit inefficient immunostimulatory capacity and block the cytotoxic activities of other antibodies. These previously unappreciated mechanisms of immune escape may constitute promising targets for the development of novel anticancer immunotherapies.",

keywords = "Antibody effector functions, B cells, Cancer inflammation, FcVRI, IgG4, IL-10, Immune escape, Melanoma, VEGF",

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AU - Nestle, Frank O.

AU - Karagiannis, Sophia N.

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AB - The role of B cells and antibodies in cancer is insufficiently understood but is receiving increasing attention. We have recently identified IgG4 as an antibody subclass elicited by melanoma-associated interleukin-10-driven inflammation. In this setting, IgG4 exhibit inefficient immunostimulatory capacity and block the cytotoxic activities of other antibodies. These previously unappreciated mechanisms of immune escape may constitute promising targets for the development of novel anticancer immunotherapies.

KW - Antibody effector functions

KW - B cells

KW - Cancer inflammation

KW - FcVRI

KW - IgG4

KW - IL-10

KW - Immune escape

KW - Melanoma

KW - VEGF

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IgG4 antibodies and cancer-associated inflammation: Insights into a novel mechanism of immune escape

Abstract

Keywords

UN SDGs

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