Imaging Biomarkers in Oncology: Basics and Application to Magnetic Resonance Imaging (MRI)

Isabel Maria Anna Dregely; Davide Prezzi; Christian Kelly-Morland; Elisa Roccia; Radhouene Neji; Vicky Joo-Lin Goh

doi:10.1002/jmri.26058

Imaging Biomarkers in Oncology: Basics and Application to Magnetic Resonance Imaging (MRI)

Isabel Maria Anna Dregely, Davide Prezzi, Christian Kelly-Morland, Elisa Roccia, Radhouene Neji, Vicky Joo-Lin Goh

Research output: Contribution to journal › Review article › peer-review

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Abstract

Cancer remains a global killer alongside cardiovascular disease. A better understanding of cancer biology has transformed its management with an increasing emphasis on a personalized approach, so-called ‘precision cancer medicine’. Imaging has a key role to play in the management of cancer patients. Imaging biomarkers that objectively inform on tumor biology, the tumor environment, and tumor changes in response to an intervention complement genomic and molecular diagnostics. In this review we describe the key principles for imaging biomarker development and discuss the current status with respect to magnetic resonance imaging (MRI).

Original language	English
Pages (from-to)	13-26
Journal	Journal of Magnetic Resonance Imaging
Volume	48
Issue number	1
Early online date	3 Jul 2018
DOIs	https://doi.org/10.1002/jmri.26058
Publication status	E-pub ahead of print - 3 Jul 2018

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Imaging Biomarkers in Oncology_DREGELY_Accepted26March2018_GREEN AAMAccepted author manuscript, 680 KB

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abstract = "Cancer remains a global killer alongside cardiovascular disease. A better understanding of cancer biology has transformed its management with an increasing emphasis on a personalized approach, so-called {\textquoteleft}precision cancer medicine{\textquoteright}. Imaging has a key role to play in the management of cancer patients. Imaging biomarkers that objectively inform on tumor biology, the tumor environment, and tumor changes in response to an intervention complement genomic and molecular diagnostics. In this review we describe the key principles for imaging biomarker development and discuss the current status with respect to magnetic resonance imaging (MRI). ",

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AU - Dregely, Isabel Maria Anna

AU - Prezzi, Davide

AU - Kelly-Morland, Christian

AU - Roccia, Elisa

AU - Neji, Radhouene

AU - Goh, Vicky Joo-Lin

PY - 2018/7/3

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N2 - Cancer remains a global killer alongside cardiovascular disease. A better understanding of cancer biology has transformed its management with an increasing emphasis on a personalized approach, so-called ‘precision cancer medicine’. Imaging has a key role to play in the management of cancer patients. Imaging biomarkers that objectively inform on tumor biology, the tumor environment, and tumor changes in response to an intervention complement genomic and molecular diagnostics. In this review we describe the key principles for imaging biomarker development and discuss the current status with respect to magnetic resonance imaging (MRI).

AB - Cancer remains a global killer alongside cardiovascular disease. A better understanding of cancer biology has transformed its management with an increasing emphasis on a personalized approach, so-called ‘precision cancer medicine’. Imaging has a key role to play in the management of cancer patients. Imaging biomarkers that objectively inform on tumor biology, the tumor environment, and tumor changes in response to an intervention complement genomic and molecular diagnostics. In this review we describe the key principles for imaging biomarker development and discuss the current status with respect to magnetic resonance imaging (MRI).

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Imaging Biomarkers in Oncology: Basics and Application to Magnetic Resonance Imaging (MRI)

Abstract

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