Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations

Miriam Vignando; Dominic Ffytche; Simon J.G. Lewis; Phil H Lee; Seok Jong Chung; Rimona Sharon Weil; Michele Hu; Clare Mackay; Ludovica Griffanti; Delphine Pins; Kathy Dujardin; Renaud Jardri; John Paul Taylor; Michael J. Firbank; Grainne McAlonan; Henry Ka-Fung Mak; Shu-Leong Ho; Mitul Mehta

Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations

Miriam Vignando, Dominic Ffytche, Simon J.G. Lewis, Phil H Lee, Seok Jong Chung, Rimona Sharon Weil, Michele Hu, Clare Mackay, Ludovica Griffanti, Delphine Pins, Kathy Dujardin, Renaud Jardri, John Paul Taylor, Michael J. Firbank, Grainne McAlonan, Henry Ka-Fung Mak, Shu-Leong Ho, Mitul Mehta

Research output: Contribution to journal › Article › peer-review

Abstract

Parkinson’s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson’s disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to pool together structural imaging data from multiple research groups into a large-scale mega-analysis, allowing us to identify cortical regions and networks involved in VH and their relation to receptor binding. Differences of morphometrics analysed show a wider cortical involvement underlying VH than previously recognised, including primary visual cortex and surrounding regions, and the hippocampus, independent of its role in cognitive decline. Structural covariance analyses point to the involvement of the attentional control networks in PD-VH, while associations with receptor density maps suggest neurotransmitter loss may be linked to the cortical changes.

Original language	English
Journal	Nature Communications
Publication status	Accepted/In press - 14 Dec 2021

Keywords

Parkinson’s disease, Parkinson’s psychosis; MRI; structural imaging; structural covariance; neurotransmitters; visual hallucinations

Cite this

Vignando, M., Ffytche, D., Lewis, S. J. G., Lee, P. H., Chung, S. J., Weil, R. S., Hu, M., Mackay, C., Griffanti, L., Pins, D., Dujardin, K., Jardri, R., Paul Taylor, J., Firbank, M. J., McAlonan, G., Ka-Fung Mak, H., Ho, S.-L., & Mehta, M. (Accepted/In press). Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations. Nature Communications.

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title = "Mapping brain structural differences and neuroreceptor correlates in Parkinson{\textquoteright}s disease visual hallucinations",

abstract = "Parkinson{\textquoteright}s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson{\textquoteright}s disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to pool together structural imaging data from multiple research groups into a large-scale mega-analysis, allowing us to identify cortical regions and networks involved in VH and their relation to receptor binding. Differences of morphometrics analysed show a wider cortical involvement underlying VH than previously recognised, including primary visual cortex and surrounding regions, and the hippocampus, independent of its role in cognitive decline. Structural covariance analyses point to the involvement of the attentional control networks in PD-VH, while associations with receptor density maps suggest neurotransmitter loss may be linked to the cortical changes.",

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author = "Miriam Vignando and Dominic Ffytche and Lewis, {Simon J.G.} and Lee, {Phil H} and Chung, {Seok Jong} and Weil, {Rimona Sharon} and Michele Hu and Clare Mackay and Ludovica Griffanti and Delphine Pins and Kathy Dujardin and Renaud Jardri and {Paul Taylor}, John and Firbank, {Michael J.} and Grainne McAlonan and {Ka-Fung Mak}, Henry and Shu-Leong Ho and Mitul Mehta",

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language = "English",

journal = "Nature Communications",

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T1 - Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations

AU - Vignando, Miriam

AU - Ffytche, Dominic

AU - Lewis, Simon J.G.

AU - Lee, Phil H

AU - Chung, Seok Jong

AU - Weil, Rimona Sharon

AU - Hu, Michele

AU - Mackay, Clare

AU - Griffanti, Ludovica

AU - Pins, Delphine

AU - Dujardin, Kathy

AU - Jardri, Renaud

AU - Paul Taylor, John

AU - Firbank, Michael J.

AU - McAlonan, Grainne

AU - Ka-Fung Mak, Henry

AU - Ho, Shu-Leong

AU - Mehta, Mitul

PY - 2021/12/14

Y1 - 2021/12/14

N2 - Parkinson’s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson’s disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to pool together structural imaging data from multiple research groups into a large-scale mega-analysis, allowing us to identify cortical regions and networks involved in VH and their relation to receptor binding. Differences of morphometrics analysed show a wider cortical involvement underlying VH than previously recognised, including primary visual cortex and surrounding regions, and the hippocampus, independent of its role in cognitive decline. Structural covariance analyses point to the involvement of the attentional control networks in PD-VH, while associations with receptor density maps suggest neurotransmitter loss may be linked to the cortical changes.

AB - Parkinson’s psychosis (PDP) describes a spectrum of symptoms that may arise in Parkinson’s disease (PD) including visual hallucinations (VH). Imaging studies investigating the neural correlates of PDP have been inconsistent in their findings, due to differences in study design and limitations of scale. Here we use empirical Bayes harmonisation to pool together structural imaging data from multiple research groups into a large-scale mega-analysis, allowing us to identify cortical regions and networks involved in VH and their relation to receptor binding. Differences of morphometrics analysed show a wider cortical involvement underlying VH than previously recognised, including primary visual cortex and surrounding regions, and the hippocampus, independent of its role in cognitive decline. Structural covariance analyses point to the involvement of the attentional control networks in PD-VH, while associations with receptor density maps suggest neurotransmitter loss may be linked to the cortical changes.

KW - Parkinson’s disease, Parkinson’s psychosis; MRI; structural imaging; structural covariance; neurotransmitters; visual hallucinations

M3 - Article

SN - 2041-1723

JO - Nature Communications

JF - Nature Communications

ER -

Mapping brain structural differences and neuroreceptor correlates in Parkinson’s disease visual hallucinations

Abstract

Keywords

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