@article{4c9fd2b1cfc143cfbedb7fc55e808c65,
title = "Mapping neurotransmitter systems to the structural and functional organization of the human neocortex",
abstract = "Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emergent function remain poorly understood, and there exists no comprehensive atlas of receptors. Here we collate positron emission tomography data from more than 1,200 healthy individuals to construct a whole-brain three-dimensional normative atlas of 19 receptors and transporters across nine different neurotransmitter systems. We found that receptor profiles align with structural connectivity and mediate function, including neurophysiological oscillatory dynamics and resting-state hemodynamic functional connectivity. Using the Neurosynth cognitive atlas, we uncovered a topographic gradient of overlapping receptor distributions that separates extrinsic and intrinsic psychological processes. Finally, we found both expected and novel associations between receptor distributions and cortical abnormality patterns across 13 disorders. We replicated all findings in an independently collected autoradiography dataset. This work demonstrates how chemoarchitecture shapes brain structure and function, providing a new direction for studying multi-scale brain organization.",
author = "Hansen, {Justine Y.} and Golia Shafiei and Markello, {Ross D.} and Kelly Smart and Cox, {Sylvia M.L.} and Martin N{\o}rgaard and Vincent Beliveau and Yanjun Wu and Gallezot, {Jean Dominique} and {\'E}tienne Aumont and Stijn Servaes and Scala, {Stephanie G.} and DuBois, {Jonathan M.} and Gabriel Wainstein and Gleb Bezgin and Thomas Funck and Schmitz, {Taylor W.} and Spreng, {R. Nathan} and Marian Galovic and Koepp, {Matthias J.} and Duncan, {John S.} and Coles, {Jonathan P.} and Fryer, {Tim D.} and Aigbirhio, {Franklin I.} and McGinnity, {Colm J.} and Alexander Hammers and Soucy, {Jean Paul} and Sylvain Baillet and Synthia Guimond and Jarmo Hietala and Bedard, {Marc Andr{\'e}} and Marco Leyton and Eliane Kobayashi and Pedro Rosa-Neto and Melanie Ganz and Knudsen, {Gitte M.} and Nicola Palomero-Gallagher and Shine, {James M.} and Carson, {Richard E.} and Lauri Tuominen and Alain Dagher and Bratislav Misic",
note = "Funding Information: We thank V. Bazinet, Z.-Q. Liu, F. Milisav, L. Suarez, B. Vazquez-Rodriguez, M. Li and A. Luppi for their comments and suggestions on the manuscript. This research was undertaken thanks, in part, to funding from the Canada First Research Excellence Fund, awarded to McGill University for the Healthy Brains for Healthy Lives initiative. B.M. acknowledges support from the Natural Sciences and Engineering Research Council of Canada (NSERC Discovery Grant RGPIN no. 017-04265) and from the Canada Research Chairs Program. J.Y.H. acknowledges support from the Helmholtz International BigBrain Analytics & Learning Laboratory, the Natural Sciences and Engineering Research Council of Canada and the Fonds de reserches de Qu{\'e}bec. M.N. acknowledges support from the Independent Research Fund Denmark (DFF-0129-00004B). E.K. acknowledges support from the Savoy Foundation for Epilepsy, the American Epilepsy Society Early Career Physician Scientist Award and the Canadian Institutes of Health Research (CIHR) MOP-93614. J.P.C. was supported by a British Journal of Anaesthesia /Royal College of Anaesthetists grant from the National Institute of Academic Anaesthesia. Some of the PET receptor data included in this manuscript were supported by Novo Nordisk Foundation grant OpenNeuroPET (0063277). Some of the PET receptor data included in this manuscript were supported by a Medical Research Council (MRC) PET Neuroscience programme grant (Training and Novel Probes Programme in PET Neurochemistry (MR/K02308X/1)) and from an MRC Developmental Pathway Funding Scheme grant (MR/L013215/1). PET receptor data collected in Cambridge were supported by the National Institute for Health and Care Research Cambridge Biomedical Research Centre (BRC-1215-20014). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Funding Information: We thank V. Bazinet, Z.-Q. Liu, F. Milisav, L. Suarez, B. Vazquez-Rodriguez, M. Li and A. Luppi for their comments and suggestions on the manuscript. This research was undertaken thanks, in part, to funding from the Canada First Research Excellence Fund, awarded to McGill University for the Healthy Brains for Healthy Lives initiative. B.M. acknowledges support from the Natural Sciences and Engineering Research Council of Canada (NSERC Discovery Grant RGPIN no. 017-04265) and from the Canada Research Chairs Program. J.Y.H. acknowledges support from the Helmholtz International BigBrain Analytics & Learning Laboratory, the Natural Sciences and Engineering Research Council of Canada and the Fonds de reserches de Qu{\'e}bec. M.N. acknowledges support from the Independent Research Fund Denmark (DFF-0129-00004B). E.K. acknowledges support from the Savoy Foundation for Epilepsy, the American Epilepsy Society Early Career Physician Scientist Award and the Canadian Institutes of Health Research (CIHR) MOP-93614. J.P.C. was supported by a British Journal of Anaesthesia/Royal College of Anaesthetists grant from the National Institute of Academic Anaesthesia. Some of the PET receptor data included in this manuscript were supported by Novo Nordisk Foundation grant OpenNeuroPET (0063277). Some of the PET receptor data included in this manuscript were supported by a Medical Research Council (MRC) PET Neuroscience programme grant (Training and Novel Probes Programme in PET Neurochemistry (MR/K02308X/1)) and from an MRC Developmental Pathway Funding Scheme grant (MR/L013215/1). PET receptor data collected in Cambridge were supported by the National Institute for Health and Care Research Cambridge Biomedical Research Centre (BRC-1215-20014). The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
month = nov,
doi = "10.1038/s41593-022-01186-3",
language = "English",
volume = "25",
pages = "1569--1581",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Research",
number = "11",
}
