Meta-Analysis Confirms the LCE3C_LCE3B Deletion as a Risk Factor for Psoriasis in Several Ethnic Groups and Finds Interaction with HLA-Cw6

Eva Riveira-Munoz; Su-Min He; Georgia Escaramis; Philip E. Stuart; Ulrike Hueffmeier; Catherine Lee; Brian Kirby; Akira Oka; Emiliano Giardina; Wilson Liao; Judith Bergboer; Kati Kainu; Rafael de Cid; Batmunkh Munkhbat; Patrick L. J. M. Zeeuwen; John A. L. Armour; Annie Poon; Tomotaka Mabuchi; Akira Ozawa; Agnieszka Zawirska; A. David Burden; Jonathan N. Barker; Francesca Capon; Heiko Traupe; Liang-Dan Sun; Yong Cui; Xian-Yong Yin; Gang Chen; Henry W. Lim; Rajan P. Nair; John J. Voorhees; Trilokraj Tejasvi; Ramon Pujol; Namid Munkhtuvshin; Judith Fischer; Juha Kere; Joost Schalkwijk; Anne M. Bowcock; Pui-Yan Kwok; Giuseppe Novelli; Hidetoshi Inoko; Anthony W. Ryan; Richard C. Trembath; Andre Reis; Xue-Jun Zhang; James T. Elder; Xavier Estivill

doi:10.1038/jid.2010.350

Meta-Analysis Confirms the LCE3C_LCE3B Deletion as a Risk Factor for Psoriasis in Several Ethnic Groups and Finds Interaction with HLA-Cw6

Eva Riveira-Munoz, Su-Min He, Georgia Escaramis, Philip E. Stuart, Ulrike Hueffmeier, Catherine Lee, Brian Kirby, Akira Oka, Emiliano Giardina, Wilson Liao, Judith Bergboer, Kati Kainu, Rafael de Cid, Batmunkh Munkhbat, Patrick L. J. M. Zeeuwen, John A. L. Armour, Annie Poon, Tomotaka Mabuchi, Akira Ozawa, Agnieszka ZawirskaA. David Burden, Jonathan N. Barker, Francesca Capon, Heiko Traupe, Liang-Dan Sun, Yong Cui, Xian-Yong Yin, Gang Chen, Henry W. Lim, Rajan P. Nair, John J. Voorhees, Trilokraj Tejasvi, Ramon Pujol, Namid Munkhtuvshin, Judith Fischer, Juha Kere, Joost Schalkwijk, Anne M. Bowcock, Pui-Yan Kwok, Giuseppe Novelli, Hidetoshi Inoko, Anthony W. Ryan, Richard C. Trembath, Andre Reis, Xue-Jun Zhang, James T. Elder, Xavier Estivill

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Abstract

A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OROverall = 1.21 (1.15-1.27)), and for the first time directly demonstrates the deletion's association with psoriasis in the Chinese (OR = 1.27 (1.16-1.34)) and Mongolian (OR = 2.08 (1.44-2.99)) populations. The analysis of the HLA-Cw6 locus showed significant differences in the epistatic interaction with the LCE3C and LCE3B deletion in at least some European populations, indicating epistatic effects between these two major genetic contributors to psoriasis. The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis.

Original language	English
Pages (from-to)	1105 - 1109
Number of pages	5
Journal	Journal of Investigative Dermatology
Volume	131
Issue number	5
DOIs	https://doi.org/10.1038/jid.2010.350
Publication status	Published - May 2011

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Riveira-Munoz, E., He, S.-M., Escaramis, G., Stuart, P. E., Hueffmeier, U., Lee, C., Kirby, B., Oka, A., Giardina, E., Liao, W., Bergboer, J., Kainu, K., de Cid, R., Munkhbat, B., Zeeuwen, P. L. J. M., Armour, J. A. L., Poon, A., Mabuchi, T., Ozawa, A., ... Estivill, X. (2011). Meta-Analysis Confirms the LCE3C_LCE3B Deletion as a Risk Factor for Psoriasis in Several Ethnic Groups and Finds Interaction with HLA-Cw6. Journal of Investigative Dermatology, 131(5), 1105 - 1109. https://doi.org/10.1038/jid.2010.350

@article{c91d7c41d7ef40dbab2286ba77d0713e,

title = "Meta-Analysis Confirms the LCE3C_LCE3B Deletion as a Risk Factor for Psoriasis in Several Ethnic Groups and Finds Interaction with HLA-Cw6",

abstract = "A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OROverall = 1.21 (1.15-1.27)), and for the first time directly demonstrates the deletion's association with psoriasis in the Chinese (OR = 1.27 (1.16-1.34)) and Mongolian (OR = 2.08 (1.44-2.99)) populations. The analysis of the HLA-Cw6 locus showed significant differences in the epistatic interaction with the LCE3C and LCE3B deletion in at least some European populations, indicating epistatic effects between these two major genetic contributors to psoriasis. The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis.",

author = "Eva Riveira-Munoz and Su-Min He and Georgia Escaramis and Stuart, {Philip E.} and Ulrike Hueffmeier and Catherine Lee and Brian Kirby and Akira Oka and Emiliano Giardina and Wilson Liao and Judith Bergboer and Kati Kainu and {de Cid}, Rafael and Batmunkh Munkhbat and Zeeuwen, {Patrick L. J. M.} and Armour, {John A. L.} and Annie Poon and Tomotaka Mabuchi and Akira Ozawa and Agnieszka Zawirska and Burden, {A. David} and Barker, {Jonathan N.} and Francesca Capon and Heiko Traupe and Liang-Dan Sun and Yong Cui and Xian-Yong Yin and Gang Chen and Lim, {Henry W.} and Nair, {Rajan P.} and Voorhees, {John J.} and Trilokraj Tejasvi and Ramon Pujol and Namid Munkhtuvshin and Judith Fischer and Juha Kere and Joost Schalkwijk and Bowcock, {Anne M.} and Pui-Yan Kwok and Giuseppe Novelli and Hidetoshi Inoko and Ryan, {Anthony W.} and Trembath, {Richard C.} and Andre Reis and Xue-Jun Zhang and Elder, {James T.} and Xavier Estivill",

year = "2011",

month = may,

doi = "10.1038/jid.2010.350",

language = "English",

volume = "131",

pages = "1105 -- 1109",

journal = "Journal of Investigative Dermatology",

issn = "1523-1747",

publisher = "Nature Publishing Group",

number = "5",

}

Riveira-Munoz, E, He, S-M, Escaramis, G, Stuart, PE, Hueffmeier, U, Lee, C, Kirby, B, Oka, A, Giardina, E, Liao, W, Bergboer, J, Kainu, K, de Cid, R, Munkhbat, B, Zeeuwen, PLJM, Armour, JAL, Poon, A, Mabuchi, T, Ozawa, A, Zawirska, A, Burden, AD, Barker, JN , Capon, F, Traupe, H, Sun, L-D, Cui, Y, Yin, X-Y, Chen, G, Lim, HW, Nair, RP, Voorhees, JJ, Tejasvi, T, Pujol, R, Munkhtuvshin, N, Fischer, J, Kere, J, Schalkwijk, J, Bowcock, AM, Kwok, P-Y, Novelli, G, Inoko, H, Ryan, AW, Trembath, RC, Reis, A, Zhang, X-J, Elder, JT & Estivill, X 2011, 'Meta-Analysis Confirms the LCE3C_LCE3B Deletion as a Risk Factor for Psoriasis in Several Ethnic Groups and Finds Interaction with HLA-Cw6', Journal of Investigative Dermatology, vol. 131, no. 5, pp. 1105 - 1109. https://doi.org/10.1038/jid.2010.350

TY - JOUR

T1 - Meta-Analysis Confirms the LCE3C_LCE3B Deletion as a Risk Factor for Psoriasis in Several Ethnic Groups and Finds Interaction with HLA-Cw6

AU - Riveira-Munoz, Eva

AU - He, Su-Min

AU - Escaramis, Georgia

AU - Stuart, Philip E.

AU - Hueffmeier, Ulrike

AU - Lee, Catherine

AU - Kirby, Brian

AU - Oka, Akira

AU - Giardina, Emiliano

AU - Liao, Wilson

AU - Bergboer, Judith

AU - Kainu, Kati

AU - de Cid, Rafael

AU - Munkhbat, Batmunkh

AU - Zeeuwen, Patrick L. J. M.

AU - Armour, John A. L.

AU - Poon, Annie

AU - Mabuchi, Tomotaka

AU - Ozawa, Akira

AU - Zawirska, Agnieszka

AU - Burden, A. David

AU - Barker, Jonathan N.

AU - Capon, Francesca

AU - Traupe, Heiko

AU - Sun, Liang-Dan

AU - Cui, Yong

AU - Yin, Xian-Yong

AU - Chen, Gang

AU - Lim, Henry W.

AU - Nair, Rajan P.

AU - Voorhees, John J.

AU - Tejasvi, Trilokraj

AU - Pujol, Ramon

AU - Munkhtuvshin, Namid

AU - Fischer, Judith

AU - Kere, Juha

AU - Schalkwijk, Joost

AU - Bowcock, Anne M.

AU - Kwok, Pui-Yan

AU - Novelli, Giuseppe

AU - Inoko, Hidetoshi

AU - Ryan, Anthony W.

AU - Trembath, Richard C.

AU - Reis, Andre

AU - Zhang, Xue-Jun

AU - Elder, James T.

AU - Estivill, Xavier

PY - 2011/5

Y1 - 2011/5

N2 - A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OROverall = 1.21 (1.15-1.27)), and for the first time directly demonstrates the deletion's association with psoriasis in the Chinese (OR = 1.27 (1.16-1.34)) and Mongolian (OR = 2.08 (1.44-2.99)) populations. The analysis of the HLA-Cw6 locus showed significant differences in the epistatic interaction with the LCE3C and LCE3B deletion in at least some European populations, indicating epistatic effects between these two major genetic contributors to psoriasis. The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis.

AB - A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OROverall = 1.21 (1.15-1.27)), and for the first time directly demonstrates the deletion's association with psoriasis in the Chinese (OR = 1.27 (1.16-1.34)) and Mongolian (OR = 2.08 (1.44-2.99)) populations. The analysis of the HLA-Cw6 locus showed significant differences in the epistatic interaction with the LCE3C and LCE3B deletion in at least some European populations, indicating epistatic effects between these two major genetic contributors to psoriasis. The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis.

U2 - 10.1038/jid.2010.350

DO - 10.1038/jid.2010.350

M3 - Article

SN - 1523-1747

VL - 131

SP - 1105

EP - 1109

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 5

ER -

Meta-Analysis Confirms the LCE3C_LCE3B Deletion as a Risk Factor for Psoriasis in Several Ethnic Groups and Finds Interaction with HLA-Cw6

Abstract

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