TY - JOUR
T1 - Metabolomic correlates of central adiposity and earlier-life body mass index
AU - Wulaningsih, W.
AU - Proitsi, P.
AU - Wong, A.
AU - Kuh, D.
AU - Hardy, R.
N1 - Export Date: 1 July 2019
CODEN: JLPRA
Funding details: Center for Outcomes Research and Evaluation, Yale School of Medicine
Funding details: MC_UU_12019/1, 12019/4, MC_UU_12019/2
Funding details: Medical Research Council
Funding text 1: Financial support from the Medical Research Council, which provides core funding for the MRC National Survey of Health and Development, is gratefully acknowledged. R.H. (Grant MC_UU_12019/2) and D.K. (Grants MC_UU_12019/1 and 12019/4) were also supported by the Medical Research Council. Manuscript received 23 April 2018 and in revised form 3 March 2019. Published, JLR Papers in Press, March 18, 2019 DOI https://doi.org/10.1194/jlr.P085944
Funding text 2: The MRC NSHD has been described in detail (19, 20). From this population, we included individuals with measurements of at least one circulating metabolite and information on BMI and waist and hip circumferences at age 60–64 (n = 900). A flowchart depicting Abbreviations: AGR, android-to-gynoid fat ratio; BCAA, branched-chain amino acid; CE, cholesteryl ester; MRC, Medical Research Council; NSHD, National Survey of Health and Development; OLS, ordinary least-squares; PL, phospholipid; VIP, variable importance in projection; WHR, waist-to-hip ratio; XL, very large. 1To whom correspondence should be addressed. e-mail: [email protected] The online version of this article (available at http://www.jlr.org) contains a supplement.
PY - 2019/3/18
Y1 - 2019/3/18
N2 - BMI is correlated with circulating metabolites, but few studies discuss other adiposity measures, and little is known about metabolomic correlates of BMI from early life. We investigated associations between different adiposity measures, BMI from childhood through adulthood, and metabolites quantified from serum using 1H NMR spectroscopy in 900 British men and women aged 60-64. We assessed BMI, waist-to-hip ratio (WHR), android-to-gynoid fat ratio (AGR), and BMI from childhood through adulthood. Linear regression with Bonferroni adjustment was performed to assess adiposity and metabolites. Of 233 metabolites, 168; 126; and 133 were associated with BMI, WHR, and AGR at age 60-64, respectively. Associations were strongest for HDL, particularly HDL particle size-e.g., there was 0.08 SD decrease in HDL diameter (95% CI: 0.07-0.10) with each unit increase in BMI. BMI-adjusted AGR or WHR were associated with 31 metabolites where there was no metabolome-wide association with BMI. We identified inverse associations between BMI at age 7 and glucose or glycoprotein at age 60-64 and relatively large LDL cholesteryl ester with postadolescent BMI gains. In summary, we identified metabolomic correlates of central adiposity and earlier-life BMI. These findings support opportunities to leverage metabolomics in early prevention of cardiovascular risk attributable to body fatness. © 2019 American Society for Biochemistry and Molecular Biology Inc.. All rights reserved.
AB - BMI is correlated with circulating metabolites, but few studies discuss other adiposity measures, and little is known about metabolomic correlates of BMI from early life. We investigated associations between different adiposity measures, BMI from childhood through adulthood, and metabolites quantified from serum using 1H NMR spectroscopy in 900 British men and women aged 60-64. We assessed BMI, waist-to-hip ratio (WHR), android-to-gynoid fat ratio (AGR), and BMI from childhood through adulthood. Linear regression with Bonferroni adjustment was performed to assess adiposity and metabolites. Of 233 metabolites, 168; 126; and 133 were associated with BMI, WHR, and AGR at age 60-64, respectively. Associations were strongest for HDL, particularly HDL particle size-e.g., there was 0.08 SD decrease in HDL diameter (95% CI: 0.07-0.10) with each unit increase in BMI. BMI-adjusted AGR or WHR were associated with 31 metabolites where there was no metabolome-wide association with BMI. We identified inverse associations between BMI at age 7 and glucose or glycoprotein at age 60-64 and relatively large LDL cholesteryl ester with postadolescent BMI gains. In summary, we identified metabolomic correlates of central adiposity and earlier-life BMI. These findings support opportunities to leverage metabolomics in early prevention of cardiovascular risk attributable to body fatness. © 2019 American Society for Biochemistry and Molecular Biology Inc.. All rights reserved.
KW - Epidemiology
KW - Lipids
KW - Metabolomics, obesity
KW - Nutrition
UR - http://www.scopus.com/inward/record.url?scp=85066987629&partnerID=8YFLogxK
U2 - 10.1194/jlr.P085944
DO - 10.1194/jlr.P085944
M3 - Article
SN - 0022-2275
VL - 60
SP - 1136
EP - 1143
JO - Journal of Lipid Research
JF - Journal of Lipid Research
IS - 6
ER -
