Mode of iron(iii) chelation by hexadentate hydroxypyridinones

Tao Zhou; Robert C. Hider; Xiaole Kong

doi:10.1039/c4cc10339d

Mode of iron(iii) chelation by hexadentate hydroxypyridinones

Tao Zhou, Robert C. Hider, Xiaole Kong^*

^*Corresponding author for this work

Zhejiang Gongshang University

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Tripodal hexadentate hydroxypyridin-4-ones are increasingly utilised as iron(iii) and gallium(iii) ligands, their attachment to proteins being particularly useful for positron emission tomography (PET). A widely studied tripodal ligand NTA(BuHP)<inf>3</inf>, which is reported to form 1:1 iron(iii) and gallium(iii) complexes in aqueous, media forms 2:2 complexes under physiological conditions. This important difference has implications for both iron chelation therapy and PET imaging. This journal is

Original language	English
Pages (from-to)	5614-5617
Number of pages	4
Journal	Chemical communications (Cambridge, England)
Volume	51
Issue number	26
DOIs	https://doi.org/10.1039/c4cc10339d
Publication status	Published - 4 Apr 2015

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AB - Tripodal hexadentate hydroxypyridin-4-ones are increasingly utilised as iron(iii) and gallium(iii) ligands, their attachment to proteins being particularly useful for positron emission tomography (PET). A widely studied tripodal ligand NTA(BuHP)3, which is reported to form 1:1 iron(iii) and gallium(iii) complexes in aqueous, media forms 2:2 complexes under physiological conditions. This important difference has implications for both iron chelation therapy and PET imaging. This journal is

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Mode of iron(iii) chelation by hexadentate hydroxypyridinones

Abstract

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