Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation

IMAGEN Consortium; Philip A. Spechler; Bader Chaarani; Catherine Orr; Scott Mackey; Stephen T. Higgins; Tobias Banaschewski; Arun L.W. Bokde; Uli Bromberg; Christian Büchel; Erin Burke Quinlan; Patricia J. Conrod; Sylvane Desrivières; Herta Flor; Vincent Frouin; Penny Gowland; Andreas Heinz; Bernd Ittermann; Jean Luc Martinot; Frauke Nees; Dimitri Papadopoulos Orfanos; Luise Poustka; Juliane H. Fröhner; Michael N. Smolka; Henrik Walter; Robert Whelan; Gunter Schumann; Hugh Garavan; Robert R. Althoff; Gareth Barker; Marie Laure Paillère Martinot; Eric Artiges; Herve Lemaitre; Tomáš Paus; Nora C. Vetter; Sarah Jurk; Eva Mennigen

doi:10.1016/j.jaac.2019.01.021

Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation

IMAGEN Consortium, Philip A. Spechler^*, Bader Chaarani, Catherine Orr, Scott Mackey, Stephen T. Higgins, Tobias Banaschewski, Arun L.W. Bokde, Uli Bromberg, Christian Büchel, Erin Burke Quinlan, Patricia J. Conrod, Sylvane Desrivières, Herta Flor, Vincent Frouin, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean Luc Martinot, Frauke NeesDimitri Papadopoulos Orfanos, Luise Poustka, Juliane H. Fröhner, Michael N. Smolka, Henrik Walter, Robert Whelan, Gunter Schumann, Hugh Garavan, Robert R. Althoff, Gareth Barker, Marie Laure Paillère Martinot, Eric Artiges, Herve Lemaitre, Tomáš Paus, Nora C. Vetter, Sarah Jurk, Eva Mennigen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

156 Downloads (Pure)

Abstract

Objective: To characterize the structural and functional neurobiology of a large group of adolescents exhibiting a behaviorally and emotionally dysregulated phenotype. Method: Adolescents aged 14 years from the IMAGEN study were investigated. Latent class analysis (LCA) on the Strengths and Difficulties Questionnaire (SDQ) was used to identify a class of individuals with elevated behavioral and emotional difficulties (“dysregulated”; n = 233) who were compared to a matched sample from a low symptom class (controls, n = 233). Whole-brain gray matter volume (GMV) images were compared using a general linear model with 10,000 random label permutations. Regional GMV findings were then probed for functional differences from three functional magnetic resonance imaging (fMRI) tasks. Significant brain features then informed mediation path models linking the likelihood of psychiatric disorders (DSM-IV) with dysregulation. Results: Whole-brain differences were found in the right orbitofrontal cortex (R.OFC; p < .05; k = 48), with dysregulated individuals exhibiting lower GMV. The dysregulated group also exhibited higher activity in this region during successful inhibitory control (F_1,429 = 7.53, p < .05). Path analyses indicated significant direct effects between the likelihood of psychopathologies and dysregulation. Modeling the R.OFC as a mediator returned modest partial effects, suggesting that the path linking the likelihood of an anxiety or conduct disorder diagnoses to dysregulation is partially explained by this anatomical feature. Conclusion: A large sample of dysregulated adolescents exhibited lower GMV in the R.OFC relative to controls. Dysregulated individuals also exhibited higher regional activations when exercising inhibitory control at performance levels comparable to those of controls. These findings suggest a neurobiological marker of dysregulation and highlight the role of the R.OFC in impaired emotional and behavioral control.

Original language	English
Pages (from-to)	1092-1103
Number of pages	12
Journal	Journal of the American Academy of Child and Adolescent Psychiatry
Volume	58
Issue number	11
Early online date	17 Apr 2019
DOIs	https://doi.org/10.1016/j.jaac.2019.01.021
Publication status	Published - 1 Nov 2019

Keywords

adolescence
dysregulation
orbitofrontal cortex
SDQ
VBM

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jaac.2019.01.021

Neuroimaging Evidence for Right_SPECHLER_Accepted11April2019Publishedonline17April2019_GREEN AAM (CC BY-NC-ND)Accepted author manuscript, 1.86 MBLicence: CC BY-NC-ND

Cite this

IMAGEN Consortium, Spechler, P. A., Chaarani, B., Orr, C., Mackey, S., Higgins, S. T., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Quinlan, E. B., Conrod, P. J., Desrivières, S., Flor, H., Frouin, V., Gowland, P., Heinz, A., Ittermann, B., Martinot, J. L., ... Mennigen, E. (2019). Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation. Journal of the American Academy of Child and Adolescent Psychiatry, 58(11), 1092-1103. https://doi.org/10.1016/j.jaac.2019.01.021

@article{43d8cf226542448a905d1a2bc6db55dd,

title = "Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation",

abstract = "Objective: To characterize the structural and functional neurobiology of a large group of adolescents exhibiting a behaviorally and emotionally dysregulated phenotype. Method: Adolescents aged 14 years from the IMAGEN study were investigated. Latent class analysis (LCA) on the Strengths and Difficulties Questionnaire (SDQ) was used to identify a class of individuals with elevated behavioral and emotional difficulties (“dysregulated”; n = 233) who were compared to a matched sample from a low symptom class (controls, n = 233). Whole-brain gray matter volume (GMV) images were compared using a general linear model with 10,000 random label permutations. Regional GMV findings were then probed for functional differences from three functional magnetic resonance imaging (fMRI) tasks. Significant brain features then informed mediation path models linking the likelihood of psychiatric disorders (DSM-IV) with dysregulation. Results: Whole-brain differences were found in the right orbitofrontal cortex (R.OFC; p < .05; k = 48), with dysregulated individuals exhibiting lower GMV. The dysregulated group also exhibited higher activity in this region during successful inhibitory control (F1,429 = 7.53, p < .05). Path analyses indicated significant direct effects between the likelihood of psychopathologies and dysregulation. Modeling the R.OFC as a mediator returned modest partial effects, suggesting that the path linking the likelihood of an anxiety or conduct disorder diagnoses to dysregulation is partially explained by this anatomical feature. Conclusion: A large sample of dysregulated adolescents exhibited lower GMV in the R.OFC relative to controls. Dysregulated individuals also exhibited higher regional activations when exercising inhibitory control at performance levels comparable to those of controls. These findings suggest a neurobiological marker of dysregulation and highlight the role of the R.OFC in impaired emotional and behavioral control.",

keywords = "adolescence, dysregulation, orbitofrontal cortex, SDQ, VBM",

author = "{IMAGEN Consortium} and Spechler, {Philip A.} and Bader Chaarani and Catherine Orr and Scott Mackey and Higgins, {Stephen T.} and Tobias Banaschewski and Bokde, {Arun L.W.} and Uli Bromberg and Christian B{\"u}chel and Quinlan, {Erin Burke} and Conrod, {Patricia J.} and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and Penny Gowland and Andreas Heinz and Bernd Ittermann and Martinot, {Jean Luc} and Frauke Nees and Orfanos, {Dimitri Papadopoulos} and Luise Poustka and Fr{\"o}hner, {Juliane H.} and Smolka, {Michael N.} and Henrik Walter and Robert Whelan and Gunter Schumann and Hugh Garavan and Althoff, {Robert R.} and Gareth Barker and {Paill{\`e}re Martinot}, {Marie Laure} and Eric Artiges and Herve Lemaitre and Tom{\'a}{\v s} Paus and Vetter, {Nora C.} and Sarah Jurk and Eva Mennigen",

year = "2019",

month = nov,

day = "1",

doi = "10.1016/j.jaac.2019.01.021",

language = "English",

volume = "58",

pages = "1092--1103",

journal = "Journal of the American Academy of Child and Adolescent Psychiatry",

issn = "0890-8567",

publisher = "Elsevier Limited",

number = "11",

}

IMAGEN Consortium, Spechler, PA, Chaarani, B, Orr, C, Mackey, S, Higgins, ST, Banaschewski, T, Bokde, ALW, Bromberg, U, Büchel, C, Quinlan, EB , Conrod, PJ , Desrivières, S, Flor, H, Frouin, V, Gowland, P, Heinz, A, Ittermann, B, Martinot, JL, Nees, F, Orfanos, DP, Poustka, L, Fröhner, JH, Smolka, MN, Walter, H, Whelan, R, Schumann, G, Garavan, H, Althoff, RR, Barker, G, Paillère Martinot, ML, Artiges, E, Lemaitre, H, Paus, T, Vetter, NC, Jurk, S & Mennigen, E 2019, 'Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 58, no. 11, pp. 1092-1103. https://doi.org/10.1016/j.jaac.2019.01.021

Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation. / IMAGEN Consortium; Spechler, Philip A.; Chaarani, Bader et al.
In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 58, No. 11, 01.11.2019, p. 1092-1103.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation

AU - IMAGEN Consortium

AU - Spechler, Philip A.

AU - Chaarani, Bader

AU - Orr, Catherine

AU - Mackey, Scott

AU - Higgins, Stephen T.

AU - Banaschewski, Tobias

AU - Bokde, Arun L.W.

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Quinlan, Erin Burke

AU - Conrod, Patricia J.

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean Luc

AU - Nees, Frauke

AU - Orfanos, Dimitri Papadopoulos

AU - Poustka, Luise

AU - Fröhner, Juliane H.

AU - Smolka, Michael N.

AU - Walter, Henrik

AU - Whelan, Robert

AU - Schumann, Gunter

AU - Garavan, Hugh

AU - Althoff, Robert R.

AU - Barker, Gareth

AU - Paillère Martinot, Marie Laure

AU - Artiges, Eric

AU - Lemaitre, Herve

AU - Paus, Tomáš

AU - Vetter, Nora C.

AU - Jurk, Sarah

AU - Mennigen, Eva

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Objective: To characterize the structural and functional neurobiology of a large group of adolescents exhibiting a behaviorally and emotionally dysregulated phenotype. Method: Adolescents aged 14 years from the IMAGEN study were investigated. Latent class analysis (LCA) on the Strengths and Difficulties Questionnaire (SDQ) was used to identify a class of individuals with elevated behavioral and emotional difficulties (“dysregulated”; n = 233) who were compared to a matched sample from a low symptom class (controls, n = 233). Whole-brain gray matter volume (GMV) images were compared using a general linear model with 10,000 random label permutations. Regional GMV findings were then probed for functional differences from three functional magnetic resonance imaging (fMRI) tasks. Significant brain features then informed mediation path models linking the likelihood of psychiatric disorders (DSM-IV) with dysregulation. Results: Whole-brain differences were found in the right orbitofrontal cortex (R.OFC; p < .05; k = 48), with dysregulated individuals exhibiting lower GMV. The dysregulated group also exhibited higher activity in this region during successful inhibitory control (F1,429 = 7.53, p < .05). Path analyses indicated significant direct effects between the likelihood of psychopathologies and dysregulation. Modeling the R.OFC as a mediator returned modest partial effects, suggesting that the path linking the likelihood of an anxiety or conduct disorder diagnoses to dysregulation is partially explained by this anatomical feature. Conclusion: A large sample of dysregulated adolescents exhibited lower GMV in the R.OFC relative to controls. Dysregulated individuals also exhibited higher regional activations when exercising inhibitory control at performance levels comparable to those of controls. These findings suggest a neurobiological marker of dysregulation and highlight the role of the R.OFC in impaired emotional and behavioral control.

AB - Objective: To characterize the structural and functional neurobiology of a large group of adolescents exhibiting a behaviorally and emotionally dysregulated phenotype. Method: Adolescents aged 14 years from the IMAGEN study were investigated. Latent class analysis (LCA) on the Strengths and Difficulties Questionnaire (SDQ) was used to identify a class of individuals with elevated behavioral and emotional difficulties (“dysregulated”; n = 233) who were compared to a matched sample from a low symptom class (controls, n = 233). Whole-brain gray matter volume (GMV) images were compared using a general linear model with 10,000 random label permutations. Regional GMV findings were then probed for functional differences from three functional magnetic resonance imaging (fMRI) tasks. Significant brain features then informed mediation path models linking the likelihood of psychiatric disorders (DSM-IV) with dysregulation. Results: Whole-brain differences were found in the right orbitofrontal cortex (R.OFC; p < .05; k = 48), with dysregulated individuals exhibiting lower GMV. The dysregulated group also exhibited higher activity in this region during successful inhibitory control (F1,429 = 7.53, p < .05). Path analyses indicated significant direct effects between the likelihood of psychopathologies and dysregulation. Modeling the R.OFC as a mediator returned modest partial effects, suggesting that the path linking the likelihood of an anxiety or conduct disorder diagnoses to dysregulation is partially explained by this anatomical feature. Conclusion: A large sample of dysregulated adolescents exhibited lower GMV in the R.OFC relative to controls. Dysregulated individuals also exhibited higher regional activations when exercising inhibitory control at performance levels comparable to those of controls. These findings suggest a neurobiological marker of dysregulation and highlight the role of the R.OFC in impaired emotional and behavioral control.

KW - adolescence

KW - dysregulation

KW - orbitofrontal cortex

KW - SDQ

KW - VBM

UR - http://www.scopus.com/inward/record.url?scp=85073489068&partnerID=8YFLogxK

U2 - 10.1016/j.jaac.2019.01.021

DO - 10.1016/j.jaac.2019.01.021

M3 - Article

C2 - 31004740

AN - SCOPUS:85073489068

SN - 0890-8567

VL - 58

SP - 1092

EP - 1103

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

IS - 11

ER -

Neuroimaging Evidence for Right Orbitofrontal Cortex Differences in Adolescents With Emotional and Behavioral Dysregulation

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this