No selection for CCR5 coreceptor usage  during parenteral transmission of macrophagetropic syncytium-inducing human immunodeficiency virus type 1.

FA Koning; D Schols; H Schuitemaker

doi:10.1128/JVI.75.18.8848-8853.2001

No selection for CCR5 coreceptor usage during parenteral transmission of macrophagetropic syncytium-inducing human immunodeficiency virus type 1.

FA Koning, D Schols, H Schuitemaker

Infectious Diseases

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

In two cases of parenteral transmission of human immunodeficiency virus type 1 (HIV-1) syncitium-inducing (SI) variants, we previously observed selection for macrophagetropic variants. Although infection of macrophages is generally mediated via CCR5, we found no selection for SI variants that could use CCR5 as coreceptor in addition to CXCR4, suggesting that features other than coreceptor usage account for the macrophagetropism of these transmitted SI HIV-1 variants

Original language	English
Pages (from-to)	8848 - 8853
Number of pages	6
Journal	Journal of Virology
Volume	75
Issue number	18
DOIs	https://doi.org/10.1128/JVI.75.18.8848-8853.2001
Publication status	Published - 2001

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10.1128/JVI.75.18.8848-8853.2001

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title = "No selection for CCR5 coreceptor usage during parenteral transmission of macrophagetropic syncytium-inducing human immunodeficiency virus type 1.",

abstract = "In two cases of parenteral transmission of human immunodeficiency virus type 1 (HIV-1) syncitium-inducing (SI) variants, we previously observed selection for macrophagetropic variants. Although infection of macrophages is generally mediated via CCR5, we found no selection for SI variants that could use CCR5 as coreceptor in addition to CXCR4, suggesting that features other than coreceptor usage account for the macrophagetropism of these transmitted SI HIV-1 variants",

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AU - Schols, D

AU - Schuitemaker, H

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N2 - In two cases of parenteral transmission of human immunodeficiency virus type 1 (HIV-1) syncitium-inducing (SI) variants, we previously observed selection for macrophagetropic variants. Although infection of macrophages is generally mediated via CCR5, we found no selection for SI variants that could use CCR5 as coreceptor in addition to CXCR4, suggesting that features other than coreceptor usage account for the macrophagetropism of these transmitted SI HIV-1 variants

AB - In two cases of parenteral transmission of human immunodeficiency virus type 1 (HIV-1) syncitium-inducing (SI) variants, we previously observed selection for macrophagetropic variants. Although infection of macrophages is generally mediated via CCR5, we found no selection for SI variants that could use CCR5 as coreceptor in addition to CXCR4, suggesting that features other than coreceptor usage account for the macrophagetropism of these transmitted SI HIV-1 variants

U2 - 10.1128/JVI.75.18.8848-8853.2001

DO - 10.1128/JVI.75.18.8848-8853.2001

M3 - Article

SN - 1098-5514

VL - 75

SP - 8848

EP - 8853

JO - Journal of Virology

JF - Journal of Virology

IS - 18

ER -

No selection for CCR5 coreceptor usage during parenteral transmission of macrophagetropic syncytium-inducing human immunodeficiency virus type 1.

Abstract

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