Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy

Anita C. Hoskins; Adam Jacques; Sonya C. Bardswell; William J. McKenna; Victor Tsang; Cristobal G. dos Remedios; Elisabeth Ehler; Kim Adams; Shapour Jalilzadeh; Metin Avkiran; Hugh Watkins; Charles Redwood; Steven B. Marston; Jonathan C. Kentish

doi:10.1016/j.yjmcc.2010.06.006

Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy

Anita C. Hoskins, Adam Jacques, Sonya C. Bardswell, William J. McKenna, Victor Tsang, Cristobal G. dos Remedios, Elisabeth Ehler, Kim Adams, Shapour Jalilzadeh, Metin Avkiran, Hugh Watkins, Charles Redwood, Steven B. Marston, Jonathan C. Kentish

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Abstract

Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy, increased ventricular stiffness and impaired diastolic filling. We investigated to what extent myocardial functional defects can be explained by alterations in the passive and active properties of human cardiac myofibrils. Skinned ventricular myocytes were prepared from patients with obstructive HCM (two patients with MYBPC3 mutations, one with a MYH7 mutation, and three with no mutation in either gene) and from four donors. Passive stiffness, viscous properties, and titin isoform expression were similar in HCM myocytes and donor myocytes. Maximal Ca2+-activated force was much lower in HCM myocytes (14 +/- 1 kN/m(2)) than in donor myocytes (23 +/- 3 kN/m(2); P

Original language	English
Pages (from-to)	737 - 745
Number of pages	9
Journal	Journal of Molecular and Cellular Cardiology
Volume	49
Issue number	5
DOIs	https://doi.org/10.1016/j.yjmcc.2010.06.006
Publication status	Published - Nov 2010

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Hoskins, A. C., Jacques, A., Bardswell, S. C., McKenna, W. J., Tsang, V., dos Remedios, C. G., Ehler, E., Adams, K., Jalilzadeh, S., Avkiran, M., Watkins, H., Redwood, C., Marston, S. B., & Kentish, J. C. (2010). Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy. Journal of Molecular and Cellular Cardiology, 49(5), 737 - 745. https://doi.org/10.1016/j.yjmcc.2010.06.006

@article{affa325161d844999989e5905de76abc,

title = "Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy",

abstract = "Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy, increased ventricular stiffness and impaired diastolic filling. We investigated to what extent myocardial functional defects can be explained by alterations in the passive and active properties of human cardiac myofibrils. Skinned ventricular myocytes were prepared from patients with obstructive HCM (two patients with MYBPC3 mutations, one with a MYH7 mutation, and three with no mutation in either gene) and from four donors. Passive stiffness, viscous properties, and titin isoform expression were similar in HCM myocytes and donor myocytes. Maximal Ca2+-activated force was much lower in HCM myocytes (14 +/- 1 kN/m(2)) than in donor myocytes (23 +/- 3 kN/m(2); P",

author = "Hoskins, {Anita C.} and Adam Jacques and Bardswell, {Sonya C.} and McKenna, {William J.} and Victor Tsang and {dos Remedios}, {Cristobal G.} and Elisabeth Ehler and Kim Adams and Shapour Jalilzadeh and Metin Avkiran and Hugh Watkins and Charles Redwood and Marston, {Steven B.} and Kentish, {Jonathan C.}",

year = "2010",

month = nov,

doi = "10.1016/j.yjmcc.2010.06.006",

language = "English",

volume = "49",

pages = "737 -- 745",

journal = "Journal of Molecular and Cellular Cardiology",

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publisher = "ACADEMIC PRESS INC",

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Hoskins, AC, Jacques, A, Bardswell, SC, McKenna, WJ, Tsang, V, dos Remedios, CG, Ehler, E, Adams, K, Jalilzadeh, S, Avkiran, M, Watkins, H, Redwood, C, Marston, SB & Kentish, JC 2010, 'Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy', Journal of Molecular and Cellular Cardiology, vol. 49, no. 5, pp. 737 - 745. https://doi.org/10.1016/j.yjmcc.2010.06.006

TY - JOUR

T1 - Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy

AU - Hoskins, Anita C.

AU - Jacques, Adam

AU - Bardswell, Sonya C.

AU - McKenna, William J.

AU - Tsang, Victor

AU - dos Remedios, Cristobal G.

AU - Ehler, Elisabeth

AU - Adams, Kim

AU - Jalilzadeh, Shapour

AU - Avkiran, Metin

AU - Watkins, Hugh

AU - Redwood, Charles

AU - Marston, Steven B.

AU - Kentish, Jonathan C.

PY - 2010/11

Y1 - 2010/11

N2 - Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy, increased ventricular stiffness and impaired diastolic filling. We investigated to what extent myocardial functional defects can be explained by alterations in the passive and active properties of human cardiac myofibrils. Skinned ventricular myocytes were prepared from patients with obstructive HCM (two patients with MYBPC3 mutations, one with a MYH7 mutation, and three with no mutation in either gene) and from four donors. Passive stiffness, viscous properties, and titin isoform expression were similar in HCM myocytes and donor myocytes. Maximal Ca2+-activated force was much lower in HCM myocytes (14 +/- 1 kN/m(2)) than in donor myocytes (23 +/- 3 kN/m(2); P

AB - Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy, increased ventricular stiffness and impaired diastolic filling. We investigated to what extent myocardial functional defects can be explained by alterations in the passive and active properties of human cardiac myofibrils. Skinned ventricular myocytes were prepared from patients with obstructive HCM (two patients with MYBPC3 mutations, one with a MYH7 mutation, and three with no mutation in either gene) and from four donors. Passive stiffness, viscous properties, and titin isoform expression were similar in HCM myocytes and donor myocytes. Maximal Ca2+-activated force was much lower in HCM myocytes (14 +/- 1 kN/m(2)) than in donor myocytes (23 +/- 3 kN/m(2); P

U2 - 10.1016/j.yjmcc.2010.06.006

DO - 10.1016/j.yjmcc.2010.06.006

M3 - Article

SN - 1095-8584

VL - 49

SP - 737

EP - 745

JO - Journal of Molecular and Cellular Cardiology

JF - Journal of Molecular and Cellular Cardiology

IS - 5

ER -

Normal passive viscoelasticity but abnormal myofibrillar force generation in human hypertrophic cardiomyopathy

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