TY - JOUR
T1 - Ocular Manifestations of Chikungunya Infection
T2 - A Systematic Review
AU - da Silva, Liziane Cristine Malaquias
AU - da Silva Platner, Fernanda
AU - da Silva Fonseca, Lauany
AU - Rossato, Virgílio Frota
AU - de Andrade, Dian Carlos Pereira
AU - de Sousa Valente, João
AU - Brain, Susan Diana
AU - Fernandes, Elizabeth Soares
N1 - Funding Information:
This work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; Brazil; grant numbers: 305676/2019-9 and 408053/2018-6), INCT-INOVAMED and the Instituto de Pesquisa Pelé Pequeno Príncipe (Brazil). LCMS is a PhD student receiving a grant from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES; finance code 001; Brazil).
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/3/29
Y1 - 2022/3/29
N2 - The Chikungunya virus (CHIKV) can cause long lasting symptoms and manifestations. However, there is little information on which ocular ones are most frequent following infection. We performed a systematic review (registered in the International Prospective Register of Systematic Reviews; no CRD42020171928) to establish the most frequent ocular manifestations of CHIKV infection and their associations with gender and age. Articles published until September 2020 were selected from PubMed, Scielo, Cochrane and Scopus databases. Only studies with CHIKV-infected patients and eye alterations were included. Reviews, descriptive studies, or those not investigating the human ocular manifestations of CHIKV, those with patients with other diseases and infections, abstracts and studies without relevant data were excluded. Twenty-five studies were selected for inclusion. Their risk of bias was evaluated by a modified Newcastle-Ottawa scale. The most frequent ocular symptoms of CHIKV infection included ocular pain, inflammation and reduced visual acuity, whilst conjunctivitis and optic neuritis were the most common manifestations of the disease. These occurred mostly in individuals of 42 ± 9.5 years of age and woman. The few available reports on CHIKV-induced eye manifestations highlight the need for further research in the field to gather more substantial evidence linking CHIKV infection, the eye and age/gender. Nonetheless, the data emphasizes that ocular alterations are meaningful occurrences of CHIKV infection which can substantially affect quality of life.
AB - The Chikungunya virus (CHIKV) can cause long lasting symptoms and manifestations. However, there is little information on which ocular ones are most frequent following infection. We performed a systematic review (registered in the International Prospective Register of Systematic Reviews; no CRD42020171928) to establish the most frequent ocular manifestations of CHIKV infection and their associations with gender and age. Articles published until September 2020 were selected from PubMed, Scielo, Cochrane and Scopus databases. Only studies with CHIKV-infected patients and eye alterations were included. Reviews, descriptive studies, or those not investigating the human ocular manifestations of CHIKV, those with patients with other diseases and infections, abstracts and studies without relevant data were excluded. Twenty-five studies were selected for inclusion. Their risk of bias was evaluated by a modified Newcastle-Ottawa scale. The most frequent ocular symptoms of CHIKV infection included ocular pain, inflammation and reduced visual acuity, whilst conjunctivitis and optic neuritis were the most common manifestations of the disease. These occurred mostly in individuals of 42 ± 9.5 years of age and woman. The few available reports on CHIKV-induced eye manifestations highlight the need for further research in the field to gather more substantial evidence linking CHIKV infection, the eye and age/gender. Nonetheless, the data emphasizes that ocular alterations are meaningful occurrences of CHIKV infection which can substantially affect quality of life.
KW - Chikungunya infection
KW - ocular manifestations
KW - ocular symptoms
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85128413618&partnerID=8YFLogxK
U2 - 10.3390/pathogens11040412
DO - 10.3390/pathogens11040412
M3 - Review article
AN - SCOPUS:85128413618
SN - 2076-0817
VL - 11
JO - Pathogens
JF - Pathogens
IS - 4
M1 - 412
ER -
