Peripheral signatures of the clusterin-DKK neurotoxicity pathway as potential blood-based biomarkers

Simon Lovestone; Martina Sattlecker; Abhishek Dixit; Steven Kiddle; Rufina Leung; Chantal Bazenet; Megan Pritchard; Hilkka Soininen; Iwona Kloszewska; Patrizia Mecocci; Magda Tsolaki; Bruno Vellas; Alex  Stewart; Steven Williams; Sally  Nelson; Richard Dobson

doi:10.1016/j.jalz.2013.08.185

Peripheral signatures of the clusterin-DKK neurotoxicity pathway as potential blood-based biomarkers

Simon Lovestone, Martina Sattlecker, Abhishek Dixit, Steven Kiddle, Rufina Leung, Chantal Bazenet, Megan Pritchard, Hilkka Soininen, Iwona Kloszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Alex Stewart, Steven Williams, Sally Nelson, Richard Dobson

Research output: Contribution to journal › Meeting abstract › peer-review

Abstract

Clusterin is both a genetic risk factor and a potential biomarker for AD. Its role in disease however is uncertain; as a pleiotropic protein it might plausibly be involved in lipid metabolism, in innate immunity or in amyloid trafficking. Clusterin is also part of the regulation of cell survival and we recently showed that Abeta induces changes in the cellular distribution of clusterin and this in turn induces DKK1 expression and a pathway mediating neurotoxicity. An expression signature indicative of this pathway is present in brain of animals with amyloidopathy but not tauopathy and in brains of people with AD but not FTD.

Original language	Undefined/Unknown
Article number	P4-351
Pages (from-to)	P860
Number of pages	1
Journal	Alzheimer's Dementia: The Journal of the Alzheimer's Association
Volume	9
Issue number	4 Suppl
DOIs	https://doi.org/10.1016/j.jalz.2013.08.185
Publication status	Published - 1 Jul 2013

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10.1016/j.jalz.2013.08.185

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Lovestone, S., Sattlecker, M., Dixit, A., Kiddle, S., Leung, R., Bazenet, C., Pritchard, M., Soininen, H., Kloszewska, I., Mecocci, P., Tsolaki, M., Vellas, B., Stewart, A., Williams, S., Nelson, S., & Dobson, R. (2013). Peripheral signatures of the clusterin-DKK neurotoxicity pathway as potential blood-based biomarkers. Alzheimer's Dementia: The Journal of the Alzheimer's Association, 9(4 Suppl), P860. Article P4-351. https://doi.org/10.1016/j.jalz.2013.08.185

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title = "Peripheral signatures of the clusterin-DKK neurotoxicity pathway as potential blood-based biomarkers",

abstract = "Clusterin is both a genetic risk factor and a potential biomarker for AD. Its role in disease however is uncertain; as a pleiotropic protein it might plausibly be involved in lipid metabolism, in innate immunity or in amyloid trafficking. Clusterin is also part of the regulation of cell survival and we recently showed that Abeta induces changes in the cellular distribution of clusterin and this in turn induces DKK1 expression and a pathway mediating neurotoxicity. An expression signature indicative of this pathway is present in brain of animals with amyloidopathy but not tauopathy and in brains of people with AD but not FTD.",

author = "Simon Lovestone and Martina Sattlecker and Abhishek Dixit and Steven Kiddle and Rufina Leung and Chantal Bazenet and Megan Pritchard and Hilkka Soininen and Iwona Kloszewska and Patrizia Mecocci and Magda Tsolaki and Bruno Vellas and Alex Stewart and Steven Williams and Sally Nelson and Richard Dobson",

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Lovestone, S , Sattlecker, M , Dixit, A , Kiddle, S , Leung, R, Bazenet, C, Pritchard, M, Soininen, H, Kloszewska, I, Mecocci, P, Tsolaki, M, Vellas, B, Stewart, A, Williams, S, Nelson, S & Dobson, R 2013, 'Peripheral signatures of the clusterin-DKK neurotoxicity pathway as potential blood-based biomarkers', Alzheimer's Dementia: The Journal of the Alzheimer's Association, vol. 9, no. 4 Suppl, P4-351, pp. P860. https://doi.org/10.1016/j.jalz.2013.08.185

TY - JOUR

T1 - Peripheral signatures of the clusterin-DKK neurotoxicity pathway as potential blood-based biomarkers

AU - Lovestone, Simon

AU - Sattlecker, Martina

AU - Dixit, Abhishek

AU - Kiddle, Steven

AU - Leung, Rufina

AU - Bazenet, Chantal

AU - Pritchard, Megan

AU - Soininen, Hilkka

AU - Kloszewska, Iwona

AU - Mecocci, Patrizia

AU - Tsolaki, Magda

AU - Vellas, Bruno

AU - Stewart, Alex

AU - Williams, Steven

AU - Nelson, Sally

AU - Dobson, Richard

PY - 2013/7/1

Y1 - 2013/7/1

N2 - Clusterin is both a genetic risk factor and a potential biomarker for AD. Its role in disease however is uncertain; as a pleiotropic protein it might plausibly be involved in lipid metabolism, in innate immunity or in amyloid trafficking. Clusterin is also part of the regulation of cell survival and we recently showed that Abeta induces changes in the cellular distribution of clusterin and this in turn induces DKK1 expression and a pathway mediating neurotoxicity. An expression signature indicative of this pathway is present in brain of animals with amyloidopathy but not tauopathy and in brains of people with AD but not FTD.

AB - Clusterin is both a genetic risk factor and a potential biomarker for AD. Its role in disease however is uncertain; as a pleiotropic protein it might plausibly be involved in lipid metabolism, in innate immunity or in amyloid trafficking. Clusterin is also part of the regulation of cell survival and we recently showed that Abeta induces changes in the cellular distribution of clusterin and this in turn induces DKK1 expression and a pathway mediating neurotoxicity. An expression signature indicative of this pathway is present in brain of animals with amyloidopathy but not tauopathy and in brains of people with AD but not FTD.

U2 - 10.1016/j.jalz.2013.08.185

DO - 10.1016/j.jalz.2013.08.185

M3 - Meeting abstract

VL - 9

SP - P860

JO - Alzheimer's Dementia: The Journal of the Alzheimer's Association

JF - Alzheimer's Dementia: The Journal of the Alzheimer's Association

IS - 4 Suppl

M1 - P4-351

ER -