Skin immune sentinels in health and disease

Frank O. Nestle; Paola Di Meglio; Jian-Zhong Qin; Brian J. Nickoloff

doi:10.1038/nri2622

Skin immune sentinels in health and disease

Frank O. Nestle, Paola Di Meglio, Jian-Zhong Qin, Brian J. Nickoloff

Dermatology

Research output: Contribution to journal › Literature review › peer-review

1066 Citations (Scopus)

Abstract

Human skin and its immune cells provide essential protection of the human body from injury and infection. Recent studies reinforce the importance of keratinocytes as sensors of danger through alert systems such as the inflammasome. In addition, newly identified CD103(+) dendritic cells are strategically positioned for cross-presentation of skin-tropic pathogens and accumulating data highlight a key role of tissue-resident rather than circulating T cells in skin homeostasis and pathology. This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease.

Original language	English
Pages (from-to)	679 - 691
Number of pages	13
Journal	NATURE REVIEWS IMMUNOLOGY
Volume	9
Issue number	10
DOIs	https://doi.org/10.1038/nri2622
Publication status	Published - Oct 2009

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10.1038/nri2622

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title = "Skin immune sentinels in health and disease",

abstract = "Human skin and its immune cells provide essential protection of the human body from injury and infection. Recent studies reinforce the importance of keratinocytes as sensors of danger through alert systems such as the inflammasome. In addition, newly identified CD103(+) dendritic cells are strategically positioned for cross-presentation of skin-tropic pathogens and accumulating data highlight a key role of tissue-resident rather than circulating T cells in skin homeostasis and pathology. This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease.",

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AU - Nestle, Frank O.

AU - Di Meglio, Paola

AU - Qin, Jian-Zhong

AU - Nickoloff, Brian J.

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N2 - Human skin and its immune cells provide essential protection of the human body from injury and infection. Recent studies reinforce the importance of keratinocytes as sensors of danger through alert systems such as the inflammasome. In addition, newly identified CD103(+) dendritic cells are strategically positioned for cross-presentation of skin-tropic pathogens and accumulating data highlight a key role of tissue-resident rather than circulating T cells in skin homeostasis and pathology. This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease.

AB - Human skin and its immune cells provide essential protection of the human body from injury and infection. Recent studies reinforce the importance of keratinocytes as sensors of danger through alert systems such as the inflammasome. In addition, newly identified CD103(+) dendritic cells are strategically positioned for cross-presentation of skin-tropic pathogens and accumulating data highlight a key role of tissue-resident rather than circulating T cells in skin homeostasis and pathology. This Review focuses on recent progress in dissecting the functional role of skin immune cells in skin disease.

U2 - 10.1038/nri2622

DO - 10.1038/nri2622

M3 - Literature review

VL - 9

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JO - NATURE REVIEWS IMMUNOLOGY

JF - NATURE REVIEWS IMMUNOLOGY

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ER -

Skin immune sentinels in health and disease

Abstract

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