Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume

Valeria Mondelli; Annamaria Cattaneo; Martino Belvederi Murri; Marta Di Forti; Rowena Handley; Nilay Hepgul; Ana Miorelli; Serena Navari; Andrew S Papadopoulos; Katherine J Aitchison; Craig Morgan; Robin M Murray; Paola Dazzan; Carmine M Pariante

doi:10.4088/JCP.10m06745

Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume

Valeria Mondelli, Annamaria Cattaneo, Martino Belvederi Murri, Marta Di Forti, Rowena Handley, Nilay Hepgul, Ana Miorelli, Serena Navari, Andrew S Papadopoulos, Katherine J Aitchison, Craig Morgan, Robin M Murray, Paola Dazzan, Carmine M Pariante

Research output: Contribution to journal › Article › peer-review

256 Citations (Scopus)

Abstract

BACKGROUND: Protecting and promoting the health of obese people is an important public health concern. This study evaluated the recording of body mass index and medical diagnostic codes for obesity in obese patients in UK primary care.

METHODS: A cohort study was implemented in the UK General Practice Research Database. Subjects were aged 18-100 years and were diagnosed with obesity between 1997 and 2007. The frequency of obesity monitoring was evaluated.

RESULTS: There were 67 000 obese patients at 127 family practices. The proportion of obese patients with no annual body mass index (BMI) record reached 65% of men and 63% of women in 2000, declining to 55 and 48% in 2009. Medical diagnostic codes for obesity were infrequently recorded. The mean BMI of obese patients increased to 35.5 kg/m(2) [95% confidence interval (CI): 35.4-35.7] in men and 37.0 kg/m(2) (95% CI: 36.9-37.1) in women by 2009. In 2009, 37% of obese men with BMI records, and 39% of women, showed a BMI increase of ≥1 kg/m(2) since the previous reading.

CONCLUSIONS: Obese patients do not have BMI values recorded regularly. The mean BMI of obese patients, and the proportion gaining weight over time, is increasing. Improved strategies for monitoring and managing obesity are required.

Original language	English
Pages (from-to)	1677 - 1684
Number of pages	8
Journal	Journal of Clinical Psychiatry
Volume	72
Issue number	12
DOIs	https://doi.org/10.4088/JCP.10m06745
Publication status	Published - Dec 2011

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Mondelli, V., Cattaneo, A., Belvederi Murri, M., Di Forti, M., Handley, R., Hepgul, N., Miorelli, A., Navari, S., Papadopoulos, A. S., Aitchison, K. J., Morgan, C., Murray, R. M., Dazzan, P., & Pariante, C. M. (2011). Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume. Journal of Clinical Psychiatry, 72(12), 1677 - 1684. https://doi.org/10.4088/JCP.10m06745

@article{e39d2670a35f448f82fa0ef419d4869a,

title = "Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume",

abstract = "BACKGROUND: Protecting and promoting the health of obese people is an important public health concern. This study evaluated the recording of body mass index and medical diagnostic codes for obesity in obese patients in UK primary care. METHODS: A cohort study was implemented in the UK General Practice Research Database. Subjects were aged 18-100 years and were diagnosed with obesity between 1997 and 2007. The frequency of obesity monitoring was evaluated. RESULTS: There were 67 000 obese patients at 127 family practices. The proportion of obese patients with no annual body mass index (BMI) record reached 65% of men and 63% of women in 2000, declining to 55 and 48% in 2009. Medical diagnostic codes for obesity were infrequently recorded. The mean BMI of obese patients increased to 35.5 kg/m(2) [95% confidence interval (CI): 35.4-35.7] in men and 37.0 kg/m(2) (95% CI: 36.9-37.1) in women by 2009. In 2009, 37% of obese men with BMI records, and 39% of women, showed a BMI increase of ≥1 kg/m(2) since the previous reading. CONCLUSIONS: Obese patients do not have BMI values recorded regularly. The mean BMI of obese patients, and the proportion gaining weight over time, is increasing. Improved strategies for monitoring and managing obesity are required.",

author = "Valeria Mondelli and Annamaria Cattaneo and {Belvederi Murri}, Martino and {Di Forti}, Marta and Rowena Handley and Nilay Hepgul and Ana Miorelli and Serena Navari and Papadopoulos, {Andrew S} and Aitchison, {Katherine J} and Craig Morgan and Murray, {Robin M} and Paola Dazzan and Pariante, {Carmine M}",

year = "2011",

month = dec,

doi = "10.4088/JCP.10m06745",

language = "English",

volume = "72",

pages = "1677 -- 1684",

journal = "Journal of Clinical Psychiatry",

publisher = "Physicians Postgraduate Press Inc.",

number = "12",

}

Mondelli, V , Cattaneo, A, Belvederi Murri, M, Di Forti, M , Handley, R , Hepgul, N , Miorelli, A, Navari, S, Papadopoulos, AS , Aitchison, KJ , Morgan, C , Murray, RM , Dazzan, P & Pariante, CM 2011, 'Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume', Journal of Clinical Psychiatry, vol. 72, no. 12, pp. 1677 - 1684. https://doi.org/10.4088/JCP.10m06745

TY - JOUR

T1 - Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis

T2 - a pathway to smaller hippocampal volume

AU - Mondelli, Valeria

AU - Cattaneo, Annamaria

AU - Belvederi Murri, Martino

AU - Di Forti, Marta

AU - Handley, Rowena

AU - Hepgul, Nilay

AU - Miorelli, Ana

AU - Navari, Serena

AU - Papadopoulos, Andrew S

AU - Aitchison, Katherine J

AU - Morgan, Craig

AU - Murray, Robin M

AU - Dazzan, Paola

AU - Pariante, Carmine M

PY - 2011/12

Y1 - 2011/12

N2 - BACKGROUND: Protecting and promoting the health of obese people is an important public health concern. This study evaluated the recording of body mass index and medical diagnostic codes for obesity in obese patients in UK primary care. METHODS: A cohort study was implemented in the UK General Practice Research Database. Subjects were aged 18-100 years and were diagnosed with obesity between 1997 and 2007. The frequency of obesity monitoring was evaluated. RESULTS: There were 67 000 obese patients at 127 family practices. The proportion of obese patients with no annual body mass index (BMI) record reached 65% of men and 63% of women in 2000, declining to 55 and 48% in 2009. Medical diagnostic codes for obesity were infrequently recorded. The mean BMI of obese patients increased to 35.5 kg/m(2) [95% confidence interval (CI): 35.4-35.7] in men and 37.0 kg/m(2) (95% CI: 36.9-37.1) in women by 2009. In 2009, 37% of obese men with BMI records, and 39% of women, showed a BMI increase of ≥1 kg/m(2) since the previous reading. CONCLUSIONS: Obese patients do not have BMI values recorded regularly. The mean BMI of obese patients, and the proportion gaining weight over time, is increasing. Improved strategies for monitoring and managing obesity are required.

AB - BACKGROUND: Protecting and promoting the health of obese people is an important public health concern. This study evaluated the recording of body mass index and medical diagnostic codes for obesity in obese patients in UK primary care. METHODS: A cohort study was implemented in the UK General Practice Research Database. Subjects were aged 18-100 years and were diagnosed with obesity between 1997 and 2007. The frequency of obesity monitoring was evaluated. RESULTS: There were 67 000 obese patients at 127 family practices. The proportion of obese patients with no annual body mass index (BMI) record reached 65% of men and 63% of women in 2000, declining to 55 and 48% in 2009. Medical diagnostic codes for obesity were infrequently recorded. The mean BMI of obese patients increased to 35.5 kg/m(2) [95% confidence interval (CI): 35.4-35.7] in men and 37.0 kg/m(2) (95% CI: 36.9-37.1) in women by 2009. In 2009, 37% of obese men with BMI records, and 39% of women, showed a BMI increase of ≥1 kg/m(2) since the previous reading. CONCLUSIONS: Obese patients do not have BMI values recorded regularly. The mean BMI of obese patients, and the proportion gaining weight over time, is increasing. Improved strategies for monitoring and managing obesity are required.

U2 - 10.4088/JCP.10m06745

DO - 10.4088/JCP.10m06745

M3 - Article

C2 - 21672499

VL - 72

SP - 1677

EP - 1684

JO - Journal of Clinical Psychiatry

JF - Journal of Clinical Psychiatry

IS - 12

ER -

Stress and inflammation reduce brain-derived neurotrophic factor expression in first-episode psychosis: a pathway to smaller hippocampal volume

Abstract

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