Structural magnetic resonance imaging data do not help support DSM-5 autism spectrum disorder category

Laura Pina Camacho; Sonia Villero; Leticia Boada; David Fraguas; Joost Janssen; Maria Mayoral; Cloe Llorente; Celso Arango; Mara Parellada

doi:10.1016/j.rasd.2012.08.013

Structural magnetic resonance imaging data do not help support DSM-5 autism spectrum disorder category

Laura Pina Camacho^*, Sonia Villero, Leticia Boada, David Fraguas, Joost Janssen, Maria Mayoral, Cloe Llorente, Celso Arango, Mara Parellada

^*Corresponding author for this work

Child & Adolescent Psychiatry

Research output: Contribution to journal › Article › peer-review

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Abstract

This systematic review aims to determine whether or not structural magnetic resonance imaging (sMRI) data support the DSM-5 proposal of an autism spectrum disorder (ASD) diagnostic category, and whether or not classical DSM-IV autistic disorder (AD) and Asperger syndrome (AS) categories should be subsumed into it. The most replicated sMRI findings in patients with ASD compared with healthy controls are increased total brain volume in early childhood and decreased corpus callosum volume. Regarding the notion of a spectrum, some studies support that AS and AD are similar but "quantitatively different" diagnostic categories, whereas others support that they are "qualitatively different" entities with specific brain structural abnormalities. It seems that there are still not enough arguments from sMRI data for or against subsuming DSM-IV categories under a single ASD category.

Original language	English
Pages (from-to)	333-343
Number of pages	11
Journal	Research in Autism Spectrum Disorders
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/j.rasd.2012.08.013
Publication status	Published - Feb 2013

Keywords

Asperger syndrome
Autism spectrum disorder
Autistic disorder
DSM-5
Structural magnetic resonance imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.rasd.2012.08.013

Structural magnetic resonance_PINA-CAMACHO_Accepted28August2012_GREEN AAMAccepted author manuscript, 427 KB

Cite this

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title = "Structural magnetic resonance imaging data do not help support DSM-5 autism spectrum disorder category",

abstract = "This systematic review aims to determine whether or not structural magnetic resonance imaging (sMRI) data support the DSM-5 proposal of an autism spectrum disorder (ASD) diagnostic category, and whether or not classical DSM-IV autistic disorder (AD) and Asperger syndrome (AS) categories should be subsumed into it. The most replicated sMRI findings in patients with ASD compared with healthy controls are increased total brain volume in early childhood and decreased corpus callosum volume. Regarding the notion of a spectrum, some studies support that AS and AD are similar but {"}quantitatively different{"} diagnostic categories, whereas others support that they are {"}qualitatively different{"} entities with specific brain structural abnormalities. It seems that there are still not enough arguments from sMRI data for or against subsuming DSM-IV categories under a single ASD category.",

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AU - Boada, Leticia

AU - Fraguas, David

AU - Janssen, Joost

AU - Mayoral, Maria

AU - Llorente, Cloe

AU - Arango, Celso

AU - Parellada, Mara

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KW - Autism spectrum disorder

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Structural magnetic resonance imaging data do not help support DSM-5 autism spectrum disorder category

Abstract

Keywords

UN SDGs

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