Tertiary structure prediction of SARS coronavirus helicase

Andrea Bernini; Ottavia Spiga; Vincenzo Venditti; Filippo Prischi; Luisa Bracci; Jiandong Huang; Julian A Tanner; Neri Niccolai

doi:10.1016/j.bbrc.2006.03.069

Tertiary structure prediction of SARS coronavirus helicase

Andrea Bernini, Ottavia Spiga, Vincenzo Venditti, Filippo Prischi, Luisa Bracci, Jiandong Huang, Julian A Tanner, Neri Niccolai

Randall Centre of Cell & Molecular Biophysics

University of Siena

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

SARS coronavirus, SCV, has been recently responsible of a sudden and widespread infection which caused almost 800 victims. The limited amount of SCV protein structural information is partially responsible of the lack of specific drugs against the virus. Coronavirus helicases are very conserved and peculiar proteins which have been proposed as suitable targets for antiviral drugs, such as bananins, which have been recently shown to inhibit the SCV helicase in vitro. Here, the quaternary structure of SCV helicase has been predicted, which will provide a solid foundation for the rational design of other antiviral helicase inhibitors.

Original language	English
Pages (from-to)	1101-4
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	343
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2006.03.069
Publication status	Published - 19 May 2006

Keywords

Binding Sites
Computer Simulation
DNA Helicases/chemistry
Models, Molecular
Protein Structure, Tertiary
Severe acute respiratory syndrome-related coronavirus/enzymology
Sequence Analysis, Protein
Viral Proteins/chemistry

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10.1016/j.bbrc.2006.03.069

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title = "Tertiary structure prediction of SARS coronavirus helicase",

abstract = "SARS coronavirus, SCV, has been recently responsible of a sudden and widespread infection which caused almost 800 victims. The limited amount of SCV protein structural information is partially responsible of the lack of specific drugs against the virus. Coronavirus helicases are very conserved and peculiar proteins which have been proposed as suitable targets for antiviral drugs, such as bananins, which have been recently shown to inhibit the SCV helicase in vitro. Here, the quaternary structure of SCV helicase has been predicted, which will provide a solid foundation for the rational design of other antiviral helicase inhibitors.",

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T1 - Tertiary structure prediction of SARS coronavirus helicase

AU - Bernini, Andrea

AU - Spiga, Ottavia

AU - Venditti, Vincenzo

AU - Prischi, Filippo

AU - Bracci, Luisa

AU - Huang, Jiandong

AU - Tanner, Julian A

AU - Niccolai, Neri

PY - 2006/5/19

Y1 - 2006/5/19

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AB - SARS coronavirus, SCV, has been recently responsible of a sudden and widespread infection which caused almost 800 victims. The limited amount of SCV protein structural information is partially responsible of the lack of specific drugs against the virus. Coronavirus helicases are very conserved and peculiar proteins which have been proposed as suitable targets for antiviral drugs, such as bananins, which have been recently shown to inhibit the SCV helicase in vitro. Here, the quaternary structure of SCV helicase has been predicted, which will provide a solid foundation for the rational design of other antiviral helicase inhibitors.

KW - Binding Sites

KW - Computer Simulation

KW - DNA Helicases/chemistry

KW - Models, Molecular

KW - Protein Structure, Tertiary

KW - Severe acute respiratory syndrome-related coronavirus/enzymology

KW - Sequence Analysis, Protein

KW - Viral Proteins/chemistry

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DO - 10.1016/j.bbrc.2006.03.069

M3 - Article

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SP - 1101

EP - 1104

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

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ER -

Tertiary structure prediction of SARS coronavirus helicase

Abstract

Keywords

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