The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis

Antonella Di Cesare; Paola Di Meglio; Frank O. Nestle

doi:10.1038/jid.2009.59

The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis

Antonella Di Cesare, Paola Di Meglio, Frank O. Nestle

Research output: Contribution to journal › Literature review › peer-review

922 Citations (Scopus)

Abstract

Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in humans, put the spotlight on a new subset of T helper (Th) cells, in part characterized by their production of IL-17 and accordingly named Th17 cells. Here, we review the development, characterization, and function of human Th17 cells as well as the crucial role of IL-23 in the context of Th17-cell-dependent chronic inflammation in psoriasis. We further discuss recent clinical trials targeting the IL-23/Th17 axis in psoriasis. Journal of Investigative Dermatology (2009) 129, 1339-1350; doi:10.1038/jid.2009.59; published online 26 March 2009

Original language	English
Pages (from-to)	1339 - 1350
Number of pages	12
Journal	Journal of Investigative Dermatology
Volume	129
Issue number	6
DOIs	https://doi.org/10.1038/jid.2009.59
Publication status	Published - Jun 2009

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10.1038/jid.2009.59

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title = "The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis",

abstract = "Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in humans, put the spotlight on a new subset of T helper (Th) cells, in part characterized by their production of IL-17 and accordingly named Th17 cells. Here, we review the development, characterization, and function of human Th17 cells as well as the crucial role of IL-23 in the context of Th17-cell-dependent chronic inflammation in psoriasis. We further discuss recent clinical trials targeting the IL-23/Th17 axis in psoriasis. Journal of Investigative Dermatology (2009) 129, 1339-1350; doi:10.1038/jid.2009.59; published online 26 March 2009",

author = "{Di Cesare}, Antonella and {Di Meglio}, Paola and Nestle, {Frank O.}",

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AU - Di Cesare, Antonella

AU - Di Meglio, Paola

AU - Nestle, Frank O.

PY - 2009/6

Y1 - 2009/6

N2 - Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in humans, put the spotlight on a new subset of T helper (Th) cells, in part characterized by their production of IL-17 and accordingly named Th17 cells. Here, we review the development, characterization, and function of human Th17 cells as well as the crucial role of IL-23 in the context of Th17-cell-dependent chronic inflammation in psoriasis. We further discuss recent clinical trials targeting the IL-23/Th17 axis in psoriasis. Journal of Investigative Dermatology (2009) 129, 1339-1350; doi:10.1038/jid.2009.59; published online 26 March 2009

AB - Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in humans, put the spotlight on a new subset of T helper (Th) cells, in part characterized by their production of IL-17 and accordingly named Th17 cells. Here, we review the development, characterization, and function of human Th17 cells as well as the crucial role of IL-23 in the context of Th17-cell-dependent chronic inflammation in psoriasis. We further discuss recent clinical trials targeting the IL-23/Th17 axis in psoriasis. Journal of Investigative Dermatology (2009) 129, 1339-1350; doi:10.1038/jid.2009.59; published online 26 March 2009

U2 - 10.1038/jid.2009.59

DO - 10.1038/jid.2009.59

M3 - Literature review

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JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 6

ER -

The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis

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