The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens

Dimitra Repana; Joel Nulsen; Lisa Dressler; Michele Bortolomeazzi; Santhilata Kuppili Venkata; Aikaterini Tourna; Anna Yakovleva; Tommaso Palmieri; Francesca D Ciccarelli

doi:10.1186/s13059-018-1612-0

The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens

Dimitra Repana, Joel Nulsen, Lisa Dressler, Michele Bortolomeazzi, Santhilata Kuppili Venkata, Aikaterini Tourna, Anna Yakovleva, Tommaso Palmieri, Francesca D Ciccarelli

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Abstract

The Network of Cancer Genes (NCG) is a manually curated repository of 2372 genes whose somatic modifications have known or predicted cancer driver roles. These genes were collected from 275 publications, including two sources of known cancer genes and 273 cancer sequencing screens of more than 100 cancer types from 34,905 cancer donors and multiple primary sites. This represents a more than 1.5-fold content increase compared to the previous version. NCG also annotates properties of cancer genes, such as duplicability, evolutionary origin, RNA and protein expression, miRNA and protein interactions, and protein function and essentiality. NCG is accessible at http://ncg.kcl.ac.uk/ .

Original language	English
Article number	1
Number of pages	11
Journal	Genome Biology
Volume	20
Issue number	1
Early online date	3 Jan 2019
DOIs	https://doi.org/10.1186/s13059-018-1612-0
Publication status	Published - 3 Jan 2019

Keywords

Cancer genes
Cancer genomics screens
Cancer heterogeneity
Systems-level properties

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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The Network of Cancer Genes (NCG): a comprehensive catalogue of known and candidate cancer genes from cancer sequencing screens

Abstract

Keywords

UN SDGs

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