Twins discordant for schizophrenia: psychopathology of the non-schizophrenic co-twins

S. V. Argyropoulos; S. Landau; S. Kalidindi; T. Toulopoulou; D. J. Castle; R. M. Murray; M. M. Picchioni

doi:10.1111/j.1600-0447.2008.01205.x

Twins discordant for schizophrenia: psychopathology of the non-schizophrenic co-twins

S. V. Argyropoulos, S. Landau, S. Kalidindi, T. Toulopoulou, D. J. Castle, R. M. Murray, M. M. Picchioni

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Objective: Patients with schizophrenia are more likely to suffer from mood and anxiety disorders compared with the general population. We explored the aetiology of this comorbidity using a twin study design.

Method: We applied an additive genetic + unique environment (AE) random effects model in the analysis of 35 non-schizophrenic co-twins from pairs discordant for schizophrenia, and 131 control twins.

Results: Non-schizophrenic co-twins had significantly increased rates of depression (P = 0.006) and anxiety disorders (P = 0.021) compared with the control twins.

Conclusion: Our results provide evidence for a familial association between schizophrenia and anxiety and depression. This could reflect common aetiological factors contributing to each of the disorders. Future studies should attempt to investigate the relative genetic and environmental contribution to the shared risk factors for schizophrenia, mood and anxiety disorders.

Original language	English
Pages (from-to)	214-219
Number of pages	6
Journal	Acta Psychiatrica Scandinavica
Volume	118
Issue number	3
Early online date	22 May 2008
DOIs	https://doi.org/10.1111/j.1600-0447.2008.01205.x
Publication status	Published - Sept 2008

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AU - Landau, S.

AU - Kalidindi, S.

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AU - Castle, D. J.

AU - Murray, R. M.

AU - Picchioni, M. M.

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Twins discordant for schizophrenia: psychopathology of the non-schizophrenic co-twins

Abstract

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