Two Year Follow-Up of the MOSAIC Trial: a Multi-Centre Randomised Controlled Trial Comparing Two Psychological Treatments in Adult Outpatients with Broadly Defined Anorexia Nervosa

Ulrike Hermine Schmidt; Elizabeth Gabrielle Ryan; Savani Bartholdy; Bethany Gwen Renwick; Alexandra Jane Keyes; Caitlin Beth O'Hara; Jessica Kate McClelland; Anna Lose; Martha Kenyon; Hannah DeJong; Hannah Broadbent; Rachel Loomes; Lucy Serpell; Lorna Richards; Eric Johnson-Sabine; Nicky Boughton; Linette Whitehead; eva-maria bonin; Jennifer Beecham; Sabine Landau; Janet Linda Treasure

doi:10.1002/eat.22523

Two Year Follow-Up of the MOSAIC Trial: a Multi-Centre Randomised Controlled Trial Comparing Two Psychological Treatments in Adult Outpatients with Broadly Defined Anorexia Nervosa

Ulrike Hermine Schmidt, Elizabeth Gabrielle Ryan, Savani Bartholdy, Bethany Gwen Renwick, Alexandra Jane Keyes, Caitlin Beth O'Hara, Jessica Kate McClelland, Anna Lose, Martha Kenyon, Hannah DeJong, Hannah Broadbent, Rachel Loomes, Lucy Serpell, Lorna Richards, Eric Johnson-Sabine, Nicky Boughton, Linette Whitehead, eva-maria bonin, Jennifer Beecham, Sabine LandauJanet Linda Treasure

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Abstract

Objective: This study reports follow-up data from a multi-centre randomized controlled trial (n=142) comparing the Maudsley Model of Anorexia Nervosa Treatment for Adults (MANTRA) with Specialist Supportive Clinical Management (SSCM) in outpatients with broadly defined anorexia nervosa (AN). At 12 months post-randomization, all patients had statistically significant improvements in body mass index (BMI), eating disorder (ED) symptomatology and other outcomes with no differences between groups. MANTRA was more acceptable to patients. The present study assessed whether gains were maintained at 24 months post-randomization.

Methods: Follow-up data at 24 months were obtained from 73.2% of participants. Outcome measures included BMI, ED symptomatology, distress, impairment, and additional service utilization during the study period. Outcomes were analyzed using linear mixed models.

Results: There were few differences between groups. In both treatment groups, improvements in BMI, ED symptomatology, distress levels and clinical impairment were maintained or increased further. Estimated mean BMI change from baseline to 24 months was 2.16kg/m2 for SSCM and 2.25kg/m2 for MANTRA (effect sizes of 1.75 and 1.83 respectively). Most participants (83%) did not require any additional intensive treatments (e.g. hospitalization). Two SSCM patients became overweight through binge-eating.

Discussion: Both treatments have value as outpatient interventions for patients with AN.

Original language	English
Pages (from-to)	793-800
Journal	International Journal of Eating Disorders
Volume	49
Issue number	8
Early online date	6 Apr 2016
DOIs	https://doi.org/10.1002/eat.22523
Publication status	Published - Aug 2016

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10.1002/eat.22523

Two Year Follow-Up of_SCHMIDT_Accepted 1Feb2016_GREEN AAM
This is the peer reviewed version of the following article: Schmidt, U., Ryan, E. G., Bartholdy, S., Renwick, B., Keyes, A., O'Hara, C., McClelland, J., Lose, A., Kenyon, M., Dejong, H., Broadbent, H., Loomes, R., Serpell, L., Richards, L., Johnson-Sabine, E., Boughton, N., Whitehead, L., Bonin, E., Beecham, J., Landau, S. and Treasure, J. (2016), Two-year follow-up of the MOSAIC trial: A multicenter randomized controlled trial comparing two psychological treatments in adult outpatients with broadly defined anorexia nervosa. Int. J. Eat. Disord., 49: 793–800, which has been published in final form at dx.doi.org/10.1002/eat.22523. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
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Schmidt, U. H., Ryan, E. G., Bartholdy, S., Renwick, B. G., Keyes, A. J., O'Hara, C. B., McClelland, J. K., Lose, A., Kenyon, M., DeJong, H., Broadbent, H., Loomes, R., Serpell, L., Richards, L., Johnson-Sabine, E., Boughton, N., Whitehead, L., bonin, E., Beecham, J., ... Treasure, J. L. (2016). Two Year Follow-Up of the MOSAIC Trial: a Multi-Centre Randomised Controlled Trial Comparing Two Psychological Treatments in Adult Outpatients with Broadly Defined Anorexia Nervosa. International Journal of Eating Disorders, 49(8), 793-800. https://doi.org/10.1002/eat.22523

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title = "Two Year Follow-Up of the MOSAIC Trial: a Multi-Centre Randomised Controlled Trial Comparing Two Psychological Treatments in Adult Outpatients with Broadly Defined Anorexia Nervosa",

abstract = "Objective: This study reports follow-up data from a multi-centre randomized controlled trial (n=142) comparing the Maudsley Model of Anorexia Nervosa Treatment for Adults (MANTRA) with Specialist Supportive Clinical Management (SSCM) in outpatients with broadly defined anorexia nervosa (AN). At 12 months post-randomization, all patients had statistically significant improvements in body mass index (BMI), eating disorder (ED) symptomatology and other outcomes with no differences between groups. MANTRA was more acceptable to patients. The present study assessed whether gains were maintained at 24 months post-randomization. Methods: Follow-up data at 24 months were obtained from 73.2% of participants. Outcome measures included BMI, ED symptomatology, distress, impairment, and additional service utilization during the study period. Outcomes were analyzed using linear mixed models. Results: There were few differences between groups. In both treatment groups, improvements in BMI, ED symptomatology, distress levels and clinical impairment were maintained or increased further. Estimated mean BMI change from baseline to 24 months was 2.16kg/m2 for SSCM and 2.25kg/m2 for MANTRA (effect sizes of 1.75 and 1.83 respectively). Most participants (83%) did not require any additional intensive treatments (e.g. hospitalization). Two SSCM patients became overweight through binge-eating. Discussion: Both treatments have value as outpatient interventions for patients with AN. ",

author = "Schmidt, {Ulrike Hermine} and Ryan, {Elizabeth Gabrielle} and Savani Bartholdy and Renwick, {Bethany Gwen} and Keyes, {Alexandra Jane} and O'Hara, {Caitlin Beth} and McClelland, {Jessica Kate} and Anna Lose and Martha Kenyon and Hannah DeJong and Hannah Broadbent and Rachel Loomes and Lucy Serpell and Lorna Richards and Eric Johnson-Sabine and Nicky Boughton and Linette Whitehead and eva-maria bonin and Jennifer Beecham and Sabine Landau and Treasure, {Janet Linda}",

year = "2016",

month = aug,

doi = "10.1002/eat.22523",

language = "English",

volume = "49",

pages = "793--800",

journal = "International Journal of Eating Disorders",

issn = "0276-3478",

publisher = "Wiley",

number = "8",

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Schmidt, UH , Ryan, EG , Bartholdy, S , Renwick, BG , Keyes, AJ , O'Hara, CB , McClelland, JK, Lose, A, Kenyon, M, DeJong, H, Broadbent, H, Loomes, R, Serpell, L, Richards, L, Johnson-Sabine, E, Boughton, N, Whitehead, L, bonin, E, Beecham, J, Landau, S & Treasure, JL 2016, 'Two Year Follow-Up of the MOSAIC Trial: a Multi-Centre Randomised Controlled Trial Comparing Two Psychological Treatments in Adult Outpatients with Broadly Defined Anorexia Nervosa', International Journal of Eating Disorders, vol. 49, no. 8, pp. 793-800. https://doi.org/10.1002/eat.22523

Two Year Follow-Up of the MOSAIC Trial: a Multi-Centre Randomised Controlled Trial Comparing Two Psychological Treatments in Adult Outpatients with Broadly Defined Anorexia Nervosa. / Schmidt, Ulrike Hermine ; Ryan, Elizabeth Gabrielle ; Bartholdy, Savani et al.
In: International Journal of Eating Disorders, Vol. 49, No. 8, 08.2016, p. 793-800.

Research output: Contribution to journal › Article › peer-review

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T1 - Two Year Follow-Up of the MOSAIC Trial

T2 - a Multi-Centre Randomised Controlled Trial Comparing Two Psychological Treatments in Adult Outpatients with Broadly Defined Anorexia Nervosa

AU - Schmidt, Ulrike Hermine

AU - Ryan, Elizabeth Gabrielle

AU - Bartholdy, Savani

AU - Renwick, Bethany Gwen

AU - Keyes, Alexandra Jane

AU - O'Hara, Caitlin Beth

AU - McClelland, Jessica Kate

AU - Lose, Anna

AU - Kenyon, Martha

AU - DeJong, Hannah

AU - Broadbent, Hannah

AU - Loomes, Rachel

AU - Serpell, Lucy

AU - Richards, Lorna

AU - Johnson-Sabine, Eric

AU - Boughton, Nicky

AU - Whitehead, Linette

AU - bonin, eva-maria

AU - Beecham, Jennifer

AU - Landau, Sabine

AU - Treasure, Janet Linda

PY - 2016/8

Y1 - 2016/8

N2 - Objective: This study reports follow-up data from a multi-centre randomized controlled trial (n=142) comparing the Maudsley Model of Anorexia Nervosa Treatment for Adults (MANTRA) with Specialist Supportive Clinical Management (SSCM) in outpatients with broadly defined anorexia nervosa (AN). At 12 months post-randomization, all patients had statistically significant improvements in body mass index (BMI), eating disorder (ED) symptomatology and other outcomes with no differences between groups. MANTRA was more acceptable to patients. The present study assessed whether gains were maintained at 24 months post-randomization. Methods: Follow-up data at 24 months were obtained from 73.2% of participants. Outcome measures included BMI, ED symptomatology, distress, impairment, and additional service utilization during the study period. Outcomes were analyzed using linear mixed models. Results: There were few differences between groups. In both treatment groups, improvements in BMI, ED symptomatology, distress levels and clinical impairment were maintained or increased further. Estimated mean BMI change from baseline to 24 months was 2.16kg/m2 for SSCM and 2.25kg/m2 for MANTRA (effect sizes of 1.75 and 1.83 respectively). Most participants (83%) did not require any additional intensive treatments (e.g. hospitalization). Two SSCM patients became overweight through binge-eating. Discussion: Both treatments have value as outpatient interventions for patients with AN.

AB - Objective: This study reports follow-up data from a multi-centre randomized controlled trial (n=142) comparing the Maudsley Model of Anorexia Nervosa Treatment for Adults (MANTRA) with Specialist Supportive Clinical Management (SSCM) in outpatients with broadly defined anorexia nervosa (AN). At 12 months post-randomization, all patients had statistically significant improvements in body mass index (BMI), eating disorder (ED) symptomatology and other outcomes with no differences between groups. MANTRA was more acceptable to patients. The present study assessed whether gains were maintained at 24 months post-randomization. Methods: Follow-up data at 24 months were obtained from 73.2% of participants. Outcome measures included BMI, ED symptomatology, distress, impairment, and additional service utilization during the study period. Outcomes were analyzed using linear mixed models. Results: There were few differences between groups. In both treatment groups, improvements in BMI, ED symptomatology, distress levels and clinical impairment were maintained or increased further. Estimated mean BMI change from baseline to 24 months was 2.16kg/m2 for SSCM and 2.25kg/m2 for MANTRA (effect sizes of 1.75 and 1.83 respectively). Most participants (83%) did not require any additional intensive treatments (e.g. hospitalization). Two SSCM patients became overweight through binge-eating. Discussion: Both treatments have value as outpatient interventions for patients with AN.

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U2 - 10.1002/eat.22523

DO - 10.1002/eat.22523

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JO - International Journal of Eating Disorders

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ER -

Two Year Follow-Up of the MOSAIC Trial: a Multi-Centre Randomised Controlled Trial Comparing Two Psychological Treatments in Adult Outpatients with Broadly Defined Anorexia Nervosa

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