Variable-Pitch Rectangular Cross-section Radiofrequency Coils for the Nitrogen-14 Nuclear Quadrupole Resonance Investigation of Sealed Medicines Packets

Jamie Barras*, Shota Katsura, Hideo Sato-Akaba, Hideo Itozaki, Georgia Kyriakidou, Michael D. Rowe, Kaspar A. Althoefer, John A. S. Smith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The performance of rectangular radio frequency (RF) coils capable of being used to detect nuclear quadrupole resonance (NQR) signals from blister packs of medicines has been compared. The performance of a fixed-pitch RF coil was compared with that from two variable-pitch coils, one based on a design in the literature and the other optimized to obtain the most homogeneous RF field over the whole volume of the coil. It has been shown from N-14 NQR measurements with two medicines, the antibiotic ampicillin (as trihydrate) and the analgesic medicine Paracetamol, that the latter design gives NQR signal intensities almost independent of the distribution of the capsules or pills within the RF coil and is therefore more suitable for quantitative analysis.

Original languageEnglish
Article numberN/A
Pages (from-to)8970-8972
Number of pages3
JournalAnalytical Chemistry
Volume84
Issue number21
DOIs
Publication statusPublished - 6 Nov 2012

Keywords

  • TABLETS

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