Life Course Sciences

Projects

Projects per year 1994 2007 2008 2010 2011 2012 2013 2014 2015 2016 2017 2028

• 2 Not started
• 7 Active
• 534 Finished

Projects per year

Search results

• Active

  Defining direct effects of selective serotonin reuptake inhibitors at islets to improve glucose homeostasis

  Liu, B. (Primary Investigator) & Persaud, S. (Co-Investigator)

  DIABETES UK

  1/10/2024 → 30/09/2027

  Project: Research

• Defining novel regulators of human beta cell specification for transplantation therapy of type 1 diabetes

  Persaud, S. (Primary Investigator), King, A. (Co-Investigator) & Olaniru, E. (Co-Investigator)

  DIABETES UK

  5/08/2024 → 4/02/2027

  Project: Research

• Towards translation: improving the functional survival of stem cell-derived beta cells

  Persaud, S. (Primary Investigator), Jones, P. (Co-Investigator) & King, A. (Co-Investigator)

  Steve Morgan Foundation

  1/04/2024 → 30/09/2028

  Project: Research

• Using mesenchymal stromal cell secretory products to improve human islet transplantation.

  Amiel, S. (Co-Investigator), Jones, P. (Co-Investigator) & academic, A. (Co-Investigator)

  MRC Medical Research Council

  5/06/2023 → 4/06/2026

  Project: Research

• Targeting β-cell microRNA-33 (miR-33) for maintenance of islet function and improving glucose homeostasis

  Liu, B. (Primary Investigator) & Persaud, S. (Co-Investigator)

  DIABETES UK

  1/02/2022 → 31/01/2025

  Project: Research

• T-bet expression in regulatory T cells in the control of obesity and insulin resistance

  Howard, J. (Primary Investigator) & Lord, G. (Co-Investigator)

  1/12/2016 → …

  Project: Research

• Developing and trialling the DAFNE (Dose for Adjustment for Normal Eating) intervention. A lifelong approach to promote effective self management in adults with type 1 diabetes.

  Persaud, S. (Primary Investigator), Amiel, S. (Co-Investigator) & Choudhary, P. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/03/2016 → 28/02/2025

  Project: Research

• Not started

  Non-viral gene therapy for the liver for Wilson's disease

  Collins, L. (Primary Investigator), Fabre, J. (Primary Investigator) & Lipps, H. (Co-Investigator)

  Project: Research

• Senior Investigator Award

  Amiel, S. (Primary Investigator)

  Project: Research

• Finished

  Harnessing human Schwann cell-pancreatic progenitor cell interactions to optimise cell replacement therapy for type 1 diabetes

  Persaud, S. (Primary Investigator)

  MRC Medical Research Council

  1/06/2023 → 31/10/2023

  Project: Research

• Characterising the role of microRNA-33 (miR-33) deletion in improving islet transplantation outcome

  Liu, B. (Primary Investigator), King, A. (Co-Investigator) & Persaud, S. (Co-Investigator)

  Novo Nordisk UK Research Foundation

  4/01/2021 → 31/12/2023

  Project: Research

• Requirement for GPR56 in islet adaptation to metabolic stress

  Persaud, S. (Primary Investigator) & Olaniru, E. (Co-Investigator)

  Bioscientifica Trust

  19/10/2020 → 19/01/2021

  Project: Research

• MultiPepT1De Proof-of-concept/Phase IIa Study

  Tree, T. (Primary Investigator) & Peakman, M. (Co-Investigator)

  Leona M & Harry B Helmsley Charitable Trust

  1/04/2020 → 31/01/2023

  Project: Research

• C1QL1-derived proteins and peptides for the treatment of type 2 diabetes

  Persaud, S. (Primary Investigator), Jones, P. (Co-Investigator) & Bowe, J. (Co-Investigator)

  Diabetes UK

  1/01/2020 → 31/08/2023

  Project: Research

• PEG-based hydrogels for iPSCs-derived regenerative therapies for diabetes

  Sancho, R. (Primary Investigator), Gentleman, E. (Co-Investigator) & King, A. (Co-Investigator)

  MRC Medical Research Council

  1/12/2019 → 30/11/2022

  Project: Research

• Identifying obesity-induced targets in the human liver GPCR expressome: therapeutic implications for type 2 diabetes and non-alcoholic fatty liver disease

  Persaud, S. (Primary Investigator) & Atanes Juiz, P. (Co-Investigator)

  Society for Endocrinology

  1/09/2019 → 31/08/2020

  Project: Research

• Exploring the translational potential of the NPY Y4 receptor for treating Type 1 Diabetes

  Bewick, G. (Primary Investigator), Caton, P. (Co-Investigator) & King, A. (Co-Investigator)

  JDRF Juvenile Diabetes Research Foundation

  1/09/2019 → 31/10/2022

  Project: Research

  • Insulin Dependent Diabetes Mellitus 100%
  • Receptor 100%

• Elucidating off-target effects of the putative CB2 antagonist JTE 907 in human and mouse islets:implications for diabetes therapy

  Persaud, S. (Primary Investigator) & Ruz Maldonado, I. (Co-Investigator)

  Society for Endocrinology

  1/09/2019 → 31/08/2020

  Project: Research

• MultiPepT1De Proof-of-concept study: Stage 1

  Peakman, M. (Primary Investigator)

  Leona M & Harry B Helmsley Charitable Trust

  1/07/2019 → 31/12/2019

  Project: Research

• Depression and SSRIs: effects on the islet adaptation to pregnancy

  Bowe, J. (Primary Investigator) & Liu, B. (Co-Investigator)

  EFSD European Foundation for the Study of Diabetes

  1/07/2019 → 30/06/2021

  Project: Research

• Fine-tuning islet NAD levels to prevent beta-cell de-differentiation in type 2 diabetes

  Caton, P. (Primary Investigator)

  Diabetes UK

  31/05/2019 → 31/03/2023

  Project: Research

• Targeting eNAMPT to treat type 2 diabetes

  Caton, P. (Primary Investigator)

  MRC Medical Research Council

  1/04/2019 → 28/02/2021

  Project: Research

  • Non Insulin Dependent Diabetes Mellitus 100%
  • Maturity Onset Diabetes of the Young 100%

• Strengthening primary care systems for prevention and control of cardiovascular diseases in Kenya: feasibility study of health kiosks in markets

  Harding, S. (Primary Investigator), O'Keeffe, M. (Co-Investigator), Boulding, H. (Co-Investigator) & Cruickshank, K. (Co-Investigator)

  MRC Medical Research Council

  31/01/2019 → 31/01/2023

  Project: Research

• Defining the role of the chemokine receptor CCR9 in islet function: potential for therapeutic intervention in type 2 diabetes

  Persaud, S. (Primary Investigator) & Atanes Juiz, P. (Co-Investigator)

  Diabetes Research & Wellness Foundation

  2/01/2019 → 1/01/2020

  Project: Research

• What protects a female mouse model of impaired glucose tolerance from progressing to overt diabetes?

  King, A. (Primary Investigator) & Austin, A. (Co-Investigator)

  Society for Endocrinology

  1/01/2019 → 31/12/2019

  Project: Research

• A novel human peptide to treat Type 2 Diabetes

  Persaud, S. (Primary Investigator), Jones, P. (Co-Investigator) & King, A. (Co-Investigator)

  EFSD European Foundation for the Study of Diabetes

  1/01/2019 → 30/06/2020

  Project: Research

• Improving islet transplantation outcomes by harnessing the mesenchymal stromal cell secretome to target the donor islet graft and host environment

  Jones, P. (Primary Investigator) & Rackham, C. (Co-Investigator)

  Diabetes Research & Wellness Foundation

  30/12/2018 → 30/12/2021

  Project: Research

• Metabolic Surgery for the Treatment and Understanding of Non-Alcoholic Steato-Hepatitis (NASH)

  Rubino, F. (Primary Investigator), Peakman, M. (Co-Investigator), O'Keeffe, M. (Co-Investigator), Mayr, M. (Co-Investigator) & Mingrone, G. (Co-Investigator)

  NIHR National Institute For Health & Care Research, MRC Medical Research Council

  1/12/2018 → 28/02/2021

  Project: Research

• Serotonin as a paracrine regulator of beta-cell mass during pregnancy

  Bowe, J. (Primary Investigator) & Smith, L. (Co-Investigator)

  Society for Endocrinology

  1/11/2018 → 31/10/2019

  Project: Research

• Confirmation of mitochondrial DNA mutations in patients with diabetic retinopathy

  Malik, A. (Primary Investigator)

  Fight for Sight

  1/10/2018 → 31/12/2021

  Project: Research

• Characterising the origin, heterogeneity and functional maturity of the developing human pancreas at a single cell resolution

  Persaud, S. (Primary Investigator) & Olaniru, E. (Co-Investigator)

  Novo Nordisk UK Research Foundation

  1/10/2018 → 31/12/2020

  Project: Research

• Using Fluoresence-activated cell sorting (FACS) to unravel changes in stem cells and enteroendocrine cells in human jejunum after bariatric surgery

  Bewick, G. (Primary Investigator) & Tsakmaki, A. (Co-Investigator)

  Society for Endocrinology

  1/10/2018 → 30/09/2019

  Project: Research

• Characterisation and optimisation of mouse models of diabetes - using novel telemetry methods

  King, A. (Primary Investigator) & Nandi, M. (Primary Investigator)

  British Pharmacological Society

  1/09/2018 → 31/08/2021

  Project: Research

• Increasing beta-cell mass in type 2 diabetes: Does reduced NAD supply result in loss of beta-cell identity in T2D?

  Caton, P. (Primary Investigator)

  Diabetes Research & Wellness Foundation

  1/05/2018 → 30/04/2019

  Project: Research

• Hypo-RESOLVE: Hypoglycaemia - REdefining SOLutions for better liVEs

  Choudhary, P. (Primary Investigator) & Amiel, S. (Co-Investigator)

  EC European Commission, Leona M & Harry B Helmsley Charitable Trust

  1/05/2018 → 31/10/2023

  Project: Research

• Comparison of Trabeculectomy with Mitomycin-C vs. Baerveldt tube surgery with and without Mitomycin-C in black African/African-Caribbean patients with primary open angle glaucoma: a randomized feasibility trial

  Hammond, C. (Primary Investigator)

  Fight for Sight

  1/04/2018 → 17/06/2022

  Project: Research

• The UK International Clinical Site (UK Trials Group)

  Liu, Y.-F. (Primary Investigator)

  JDRF Juvenile Diabetes Research Foundation

  1/04/2018 → 31/03/2020

  Project: Research

• Inhibiting NAMPT to improve beta-cell survival and function in type 1 diabetes

  Caton, P. (Primary Investigator) & Bewick, G. (Co-Investigator)

  EFSD European Foundation for the Study of Diabetes

  1/04/2018 → 31/03/2019

  Project: Research

• Mitochondria to the rescue: A novel Mesenchymal Stromal Cell mediated mechanism of enhanced islet function, from cells to secretome

  Rackham, C. (Primary Investigator) & Jones, P. (Co-Investigator)

  1/03/2018 → 28/02/2023

  Project: Research

• STEADY: Safe management of people with Type 1 diabetes and EAting Disorder StudY (STEADY)

  Stadler, M. (Primary Investigator), Ismail, K. (Co-Investigator), Reid, F. (Co-Investigator), Robert, G. (Co-Investigator) & Treasure, J. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/03/2018 → 29/02/2024

  Project: Research

• Creating an open access knowledge hub of nutritional biomarkers for use in global health settings

  Moore, S. (Primary Investigator), Cruickshank, K. (Co-Investigator), Rodriguez Mateos, A. M. (Co-Investigator), Harding, S. (Co-Investigator) & Poston, L. (Co-Investigator)

  MRC Medical Research Council

  1/03/2018 → 28/02/2019

  Project: Research

• A role for hypothalamic hormones in the islet adaptation to pregnancy

  Bowe, J. (Primary Investigator)

  Diabetes Research & Wellness Foundation

  1/02/2018 → 31/01/2019

  Project: Research

• Repurposing metformin for the treatment of dry age-related macular degeneration (AMD)

  Jackson, T. (Primary Investigator)

  1/02/2018 → 30/09/2023

  Project: Research

• Tumour suppressor function for the AP-1 transcription factor c-Jun in Ras-induced lung cancer

  Behrens, A. (Primary Investigator)

  1/01/2018 → 31/12/2020

  Project: Research

• Generation of neuronal lineages from pluripotent stem cells

  Jones, P. (Primary Investigator)

  MRC Medical Research Council

  1/01/2018 → 30/06/2018

  Project: Research

• Targeting β-cell GPR56 for maintenance of islet structure and function to improve glucose homeostasis

  Persaud, S. (Primary Investigator), Jones, P. (Co-Investigator) & King, A. (Co-Investigator)

  Diabetes UK

  1/11/2017 → 31/10/2020

  Project: Research

• Evaluating a decellularised pancreas matrix for islet bioengineering and diabetes therapy

  King, A. (Primary Investigator)

  Diabetes UK

  1/11/2017 → 16/04/2022

  Project: Research

• FFARDiT - Diet-derived short chain fatty acids: defining the role of beta cell ffar2 in glucose homeostasis

  Persaud, S. (Primary Investigator)

  1/11/2017 → 31/10/2020

  Project: Research

• Defining the impact of short chain fatty acids on glucose homeostasis through signalling between adipocytes, gut and islets

  Persaud, S. (Primary Investigator)

  1/10/2017 → 30/09/2020

  Project: Research

• Effect of co-stimulation blockade on T cell auto reactivity in new onset Type 1 diabetes. COMBAT Type 1

  Peakman, M. (Primary Investigator) & Liu, Y.-F. (Co-Investigator)

  Novo Nordisk UK Research Foundation

  1/09/2017 → 31/08/2019

  Project: Research