Research output per year
Research output per year
Personal profile
Research interests
I am interested in why asthma remains uncontrolled in a substantial minority of patients. My research embraces the immunopathogenesis of severe asthma phenotypes such as non-atopic and aspirin sensitive asthma. I also study mechanisms of airways remodelling in asthma to identify new molecular targets which may modify the natural history of this phenomenon. I collaborate particularly with my departmental colleagues Prof Hawrylowicz, who is interested in environmental control of T regulatory cell function in asthma, including the potential roles of new therapeutic agents, Prof Ward with whom I am examining the role of bronchial smooth muscle calcium homoeostatic proteins in maintining bronchial hyperresponsiveness, the cardinal clinical feature of asthma whose genesis remains as yet unexplained, and Prof Gould with whom I investigate the role of IgE-mediated mechanisms, both established and novel, in regulating asthma severity. On the clinical side I manage the Trust omalizumab service and am running a proof of concept study of the worth of omalizumab therapy in non-atopic asthma. As leader of the Guy's allergen immunotherapy service I am also interested in improving products and regimens for immunotherapy, and participate in a number of basic and phase 3 clinical trials to this end. I am a principal investigator in the MRC and Asthma UK Centre for allergic mechanisms of Asthma, a cross-collaborative initiative with King's and Imperial Colleges, the Medical Research Council and the principal asthma charity Asthma UK.
Research interests (short)
Severe phenotypes of asthma; environmental influences on asthma control; mechanisms of airways remodelling in asthma; allergen immunotherapy.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Philosophy, The role of the T-lymphocyte in the pathogenesis of asthma, University of London
Award Date: 1 Jan 1990
Bachelor of Medicine, University of London
Award Date: 1 Jan 1983
Master of Science, Suppression of malignant potential in hybridomas between plasmacytoma and normal diploid cells, University of Oxford
Award Date: 1 Jan 1980
Bachelor of Arts, University of Oxford
Award Date: 1 Jan 1979
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Safety and anti-tumour activity of the IgE antibody MOv18 in patients with advanced solid tumours expressing folate receptor-alpha: a phase I trial
Spicer, J., Basu, B., Montes, A., Banerji, U., Kristeleit, R., Miller, R., Veal, G. J., Corrigan, C. J., Till, S. J., Figini, M., Canevari, S., Barton, C., Jones, P., Mellor, S., Carroll, S., Selkirk, C., Nintos, G., Kwatra, V., Funingana, I.-G. & Doherty, G. & 12 others, , 25 Jul 2023, In: Nature Communications. 14, 1, p. 4180 4180.Research output: Contribution to journal › Article › peer-review
Open Access9 Citations (Scopus) -
Sphingosine-1-phosphate induces airway smooth muscle hyperresponsiveness and proliferation
Maguire, T. J. A., Yung, S., Ortiz-Zapater, E., Kayode, O. S., Till, S., Corrigan, C., Siew, L. Q. C., Knock, G. A. & Woszczek, G., Nov 2023, In: Journal of Allergy and Clinical Immunology. 152, 5, p. 1131-1140.e6Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Withdrawal of inhaled corticosteroids from patients with COPD with mild or moderate airflow limitation in primary care: a feasibility randomised trial
Harries, T. H., Gilworth, G., Corrigan, C. J., Murphy, P., Hart, N., Thomas, M. & White, P. T., 30 Aug 2022, In: BMJ Open Respiratory Research. 9, 1, e001311.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
B Cell Mobilization, Dissemination, Fine Tuning of Local Antigen Specificity and Isotype Selection in Asthma
Ohm-Laursen, L., Meng, H., Hoehn, K. B., Nouri, N., Jiang, Y., Clouser, C., Johnstone, T. G., Hause, R., Sandhar, B. S., Upton, N. E. G., Chevretton, E. B., Lakhani, R., Corrigan, C. J., Kleinstein, S. H. & Gould, H. J., 14 Oct 2021, In: Frontiers in Immunology. 12, 702074.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
Characterization of negative allosteric modulators of the calcium-sensing receptor for repurposing as a treatment of asthma
Yarova, P. L., Huang, P., Schepelmann, M. W., Bruce, R., Ecker, R., Nica, R., Telezhkin, V., Traini, D., dos Reis, L. G., Kidd, E. J., Ford, W. R., Broadley, K. J., Kariuki, B. M., Corrigan, C. J., Ward, J. P. T., Kemp, P. J. & Riccardi, D., 1 Jan 2021, In: Journal of Pharmacology and Experimental Therapeutics. 376, 1, p. 51-63 13 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Citations (Scopus)
Projects
- 60 Finished
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Feasibility of the safe withdrawal of inhaled corticosteroids in patients with mild to moderate COPD prescribed outside guidelines
White, P. (Primary Investigator), Corrigan, C. (Co-Investigator), Harries, T. (Co-Investigator), Moxham, J. (Co-Investigator), Schofield, P. (Co-Investigator), Sethi, T. (Co-Investigator) & Wright, A. (Co-Investigator)
NIHR National Institute For Health & Care Research
29/08/2017 → 30/06/2019
Project: Research
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Does sphingosine-1-phosphate constrict human airways? In-vivo challenge pilot study
Woszczek, G. (Primary Investigator) & Corrigan, C. (Co-Investigator)
23/08/2017 → 22/02/2022
Project: Research
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NIHR Biomedical Research Centre. Funding for Financial Years 2017/18, 2018/19
Wolfe, C. (Primary Investigator), Parsons, M. (Primary Investigator), Gould, H. (Primary Investigator), Corrigan, C. (Primary Investigator), Greenough, A. (Primary Investigator), Peakman, M. (Primary Investigator), Vyse, T. (Primary Investigator), Antoniou, M. (Primary Investigator), Oakey, R. (Primary Investigator), McGrath, J. (Primary Investigator), Karagiannis, S. (Primary Investigator), Barker, J. (Primary Investigator), Flohr, C. (Primary Investigator), Tziotzios, C. (Primary Investigator), Whittaker, S. (Primary Investigator), Spector, T. (Primary Investigator), Watt, F. (Primary Investigator), Hayday, A. (Primary Investigator), Spencer, J. (Primary Investigator), Cope, A. (Primary Investigator), Malim, M. (Primary Investigator), Martin Serrano, J. (Primary Investigator), Edgeworth, J. (Primary Investigator), Cason, J. (Primary Investigator), Lord, G. (Primary Investigator), Dorling, A. (Primary Investigator), Sacks, S. (Primary Investigator), Sanchez Fueyo, A. (Primary Investigator), Lombardi, G. (Primary Investigator), Ostermann, M. (Primary Investigator), Shah, A. (Primary Investigator), Marber, M. (Primary Investigator), Mayr, M. (Primary Investigator), Chowienczyk, P. (Primary Investigator), Wells, C. (Primary Investigator), Grigoriadis, A. (Primary Investigator), Sawyer, E. (Primary Investigator), Maher, J. (Primary Investigator), Tribe, R. (Primary Investigator), Ilic, D. (Primary Investigator), Poston, L. (Primary Investigator), Rutherford, M. (Primary Investigator), Gee, T. (Primary Investigator), Blower, P. (Primary Investigator), Edwards, D. (Primary Investigator), Sharpe, P. (Primary Investigator), Streit, A. (Primary Investigator), Naglik, J. (Primary Investigator), Tavassoli, M. (Primary Investigator) & McNaughton, P. (Primary Investigator)
NIHR National Institute For Health & Care Research
1/04/2017 → 31/03/2022
Project: Research
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Development of a novel therapeutic for inflammatory lung disorders
Corrigan, C. (Primary Investigator) & Ward, J. (Co-Investigator)
1/01/2016 → 31/12/2019
Project: Research
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Genetic and Functional Characterization of the IgE Repertoire and Compartmental Regulation of IgE Activity in the Pathogenesis of Asthma
Gould, H. (Primary Investigator), Corrigan, C. (Co-Investigator), Tindall, L. (Co-Investigator) & Wu, B. (Co-Investigator)
15/12/2015 → 14/12/2018
Project: Research
Activities
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RCP JRCPTB Specialist Advisory Committee on Allergy & Immunology
Corrigan, C. (Chair)
2009 → 2012Activity: Other › Types of External academic engagement - Contribution to the work of national or international committees and working groups
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Reviews Editor, Clinical & Experimental Allergy (Journal)
Corrigan, C. (Editor)
2008 → 2012Activity: Publication peer-review and editorial work › Editorial activity
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Education Subcommittee, British Society for Alllergy & Clinical Immunology
Corrigan, C. (Chair)
2008 → 2012Activity: Other › Types of External academic engagement - Contribution to the work of national or international committees and working groups
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Reviews Editor, Clinical & Experimental Allergy (Journal)
Corrigan, C. (Editorial board member)
2008 → 2012Activity: Publication peer-review and editorial work › Editorial activity
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National Choose and Book keyword Coordinator Immunology & Allergy
Corrigan, C. (Member)
2005 → 2012Activity: Other › Types of External academic engagement - Contribution to the work of national or international committees and working groups