Research output per year
Research output per year
Personal profile
Research interests
- PET for risk and response adaptation in cancers treated with chemo- immuno- and radiotherapy
- Standardisation of PET and organisation of multicentre trials
- AI to provide efficiences in the radiotherapy pathway using image guidance
Biographical details
Sally Barrington trained in Nuclear Medicine at Guy’s and St Thomas’ Hospitals and was appointed as Professor of PET imaging in 2016. Her clinical experience encompasses all aspects of PET-CT including oncology, neurology, cardiology and infection/inflammation using a variety of tracers.
She was awarded a National Institute for Health Research and Social Care (NIHR) Research Professorship in December 2017.
Her research professor programme (funded NIHR) focuses on using PET to improve outcomes in cancer. It includes clinical trials exploring PET to risk and response adapt in lymphomas, enabling better targeting of therapy according to tumour biology, using PET to guide advanced radiotherapy and improving PET interpretation, including exploration of AI approaches. She is currently imaging PI for 4 late phase multicentre trials and 2 funded trials in set-up.
She co-leads the UK PET Core imaging lab with Prof Paul Marsden with a research network of over 50 imaging centres, http://www.ncri-pet.org.uk/.
She leads the clinical translation of the MITHRAS programme (funded EPSRC 2019-24) to translate novel tracers into clinic, https://www.mithrasprogramme.org/.
Harmonised standards for performing and reporting PET developed at KCL within Prof Barrington’s group included a 5-point reporting scale, which has become the international standard for response assessment in lymphoma, referred to as the ‘Deauville criteria’ and incorporated in the Lugano classification.
She is first author of International Conference on Malignant Lymphoma (ICML) guidelines for staging and response assessment in lymphoma and co-author of European Guidelines for Tumour Imaging with FDG PET-CT. She has ~150 peer reviewed publications.
Other activities:
Member of the Scientific Committee for international workshops on PET in lymphoma, European Lymphoma Institute, Lecturer on European Society of Oncology Programme awarding the Certificate of Competence in lymphoma, Steering Committee for PETRA consortium investigating PET as a biomarker of response to lymphoma therapy funded by the Dutch Cancer Society.
Member of Cancer Research UK Expert Review Panel and Medical Research Council Confidence in Concept Kings Health Partners Challenge Fund Panel, Chair of the NIHR Academy Involvement Group, Chair of the Radiation Safety Committee of Guy's and St Thomas' NHS Foundation Trust.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Doctor of Medicine, University of London
Award Date: 1 Jan 2003
Master of Science, University of London
Award Date: 1 Jan 1995
Bachelor of Medicine and Bachelor of Surgery, University of London
Award Date: 1 Jan 1987
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Collaborations and top research areas from the last five years
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Adapted Treatment Guided by Interim PET-CT Scan in Advanced Hodgkin's Lymphoma
Johnson, P., Federico, M., Kirkwood, A., Fosså, A., Berkahn, L., Carella, A., d'Amore, F., Enblad, G., Franceschetto, A., Fulham, M., Luminari, S., O'Doherty, M., Patrick, P., Roberts, T., Sidra, G., Stevens, L., Smith, P., Trotman, J., Viney, Z. & Radford, J. & 1 others, , 23 Jun 2016, In: New England Journal of Medicine. 374, 25, p. 2419-2429 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile642 Citations (Scopus)290 Downloads (Pure) -
PET-CT for staging and early response: results from the Response-Adapted Therapy in Advanced Hodgkin Lymphoma study
Barrington, S. F., Kirkwood, A. A., Franceschetto, A., Fulham, M. J., Roberts, T. H., Almquist, H., Brun, E., Hjorthaug, K., Viney, Z. N., Pike, L. C., Federico, M., Luminari, S., Radford, J., Trotman, J., Fossa, A., Berkahn, L., Molin, D., D'Amore, F., Sinclair, D. A. & Smith, P. & 3 others, , 24 Mar 2016, In: Blood. 127, 12, p. 1531-1538Research output: Contribution to journal › Article › peer-review
Open AccessFile142 Citations (Scopus)325 Downloads (Pure) -
Results of a Trial of PET-Directed Therapy for Early-Stage Hodgkin's Lymphoma
Radford, J., Illidge, T., Counsell, N., Hancock, B., Pettengell, R., Johnson, P., Wimperis, J., Culligan, D., Popova, B., Smith, P., McMillan, A., Brownell, A., Kruger, A., Lister, A., Hoskin, P., O'Doherty, M. & Barrington, S., 23 Apr 2015, In: New England Journal of Medicine. 372, 17, p. 1598-1607 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile598 Citations (Scopus)693 Downloads (Pure) -
Role of Imaging in the Staging and Response Assessment of Lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group
Barrington, S. F., Mikhaeel, N. G., Kostakoglu, L., Meignan, M., Hutchings, M., Müeller, S. P., Schwartz, L. H., Zucca, E., Fisher, R. I., Trotman, J., Hoekstra, O. S., Hicks, R. J., O'Doherty, M. J., Hustinx, R., Biggi, A. & Cheson, B. D., 20 Sept 2014, In: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 32, 27, p. 3048-3058 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile1270 Citations (Scopus)170 Downloads (Pure) -
Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification
Cheson, B. D., Fisher, R. I., Barrington, S. F., Cavalli, F., Schwartz, L. H., Lister, T. A. & Alliance, Australasian Leukaemia and Lymphoma Group, 20 Sept 2014, In: Journal of Clinical Oncology. 32, 27, p. 3059-3068 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile3929 Citations (Scopus)204 Downloads (Pure)
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National Total Body PET Centre
Hammers, A. (Primary Investigator), Barrington, S. (Co-Investigator), Blower, P. (Co-Investigator), Cook, G. (Co-Investigator), Gee, T. (Co-Investigator), Marsden, P. (Co-Investigator), Modat, M. (Co-Investigator), Nazir, M. (Co-Investigator), Ourselin, S. (Co-Investigator), Razavi, R. (Co-Investigator), Reader, A. (Co-Investigator) & Terry, S. (Co-Investigator)
1/10/2023 → 30/09/2030
Project: Research
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REFRACT relapsed follicular lymphoma randomised trial against standard chemotherapy
Barrington, S. (Primary Investigator)
1/01/2023 → 30/06/2025
Project: Research
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Smart+: MRC mid-range equipment - State-of-the-Art Equipment for Preclinical Targeted Radiotherapy
Terry, S. (Primary Investigator), Barrington, S. (Co-Investigator), Blower, P. (Co-Investigator), Fruhwirth, G. (Co-Investigator), Hewitt, G. (Co-Investigator), Kong, A. (Co-Investigator), Modarai, B. (Co-Investigator), Southworth, R. (Co-Investigator), Stasiuk, G. (Co-Investigator), Sunassee, K. (Co-Investigator), T. M. de Rosales, R. (Co-Investigator), Tavassoli, M. (Co-Investigator), Witney, T. (Co-Investigator) & Yan, R. (Co-Investigator)
1/08/2023 → 29/02/2024
Project: Research
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Wellcome/EPSRC Centre for Medical Engineering Extension
Ourselin, S. (Primary Investigator), Barker, G. (Co-Investigator), Barnes, A. (Co-Investigator), Barrington, S. (Co-Investigator), Bergeles, C. (Co-Investigator), Bishop, M. (Co-Investigator), Blower, P. (Co-Investigator), Booth, T. (Co-Investigator), Botnar, R. (Co-Investigator), Cardoso, J. (Co-Investigator), Carmichael, D. (Co-Investigator), Chiribiri, A. (Co-Investigator), Clough, R. (Co-Investigator), Cook, G. (Co-Investigator), Counsell, S. (Co-Investigator), Dasgupta, P. (Co-Investigator), De Vecchi, A. (Co-Investigator), De Vita, E. (Co-Investigator), Edwards, D. (Co-Investigator), Goh, V. (Co-Investigator), Hajnal, J. (Co-Investigator), Hammers, A. (Co-Investigator), Hutter, J. (Co-Investigator), Ipek, O. (Co-Investigator), King, A. (Co-Investigator), Lamata de la Orden, P. (Co-Investigator), Liu, H. (Co-Investigator), Malik, S. (Co-Investigator), Marsden, P. (Co-Investigator), Modat, M. (Co-Investigator), Niederer, S. (Co-Investigator), Razavi, R. (Co-Investigator), Reader, A. (Co-Investigator), Rhode, K. (Co-Investigator), Roujol, S. (Co-Investigator), Rutherford, M. (Co-Investigator), Shapey, J. (Co-Investigator), Sparks, R. (Co-Investigator), T. M. de Rosales, R. (Co-Investigator), Terry, S. (Co-Investigator), Tournier, J.-D. (Co-Investigator), Vercauteren, T. (Co-Investigator), Williams, S. (Co-Investigator), Xia, W. (Co-Investigator), Young, A. (Co-Investigator) & academic, A. (Co-Investigator)
28/04/2022 → 27/10/2024
Project: Research
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Next generation molecular imaging and therapy with radionuclides
Blower, P. (Primary Investigator), Gee, T. (Co-Investigator), Ng, T. (Co-Investigator), Barrington, S. (Co-Investigator), T. M. de Rosales, R. (Co-Investigator), Ma, M. (Co-Investigator), Fruhwirth, G. (Co-Investigator), Southworth, R. (Co-Investigator), Reader, A. (Co-Investigator), Marsden, P. (Co-Investigator) & Terry, S. (Co-Investigator)
EPSRC Engineering and Physical Sciences Research Council
1/10/2019 → 30/09/2024
Project: Research
Prizes
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British Nuclear Medicine Society Roll of Honour i
Barrington, S. (Recipient), 2019
Prize: Prize (including medals and awards)