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  Stratified medicine for cognition in schizophrenia: A proof-of-concept study with a7-nicotinic receptor agonists

  Michalopoulou, P. (Primary Investigator), Kapur, S. (Co-Investigator) & Shergill, S. (Co-Investigator)

  1/01/2016 → 31/12/2019

  Project: Research

• Does Kv3 channel modulation reduce dopamine synthesis capacity and reduce abnormal neural responses in schizophrenia?

  Howes, O. (Primary Investigator), Kapur, S. (Co-Investigator) & McGuire, P. (Co-Investigator)

  Innovate UK

  1/07/2015 → 30/06/2018

  Project: Research

• Event-related potentials to predict cognitive response to a7-nicotinic receptor agonists: a proof-of-concept study in schizophrenia

  Shergill, S. (Primary Investigator), Kapur, S. (Co-Investigator) & Michalopoulou, P. (Co-Investigator)

  1/05/2015 → 30/04/2019

  Project: Research

• Stratified medicine for cognition in schizophrenia: A proof of concept study on cognitive responses to a7 nicotinic receptor agonists

  Michalopoulou, P. (Primary Investigator), Kapur, S. (Co-Investigator) & Williams, S. (Co-Investigator)

  1/04/2015 → 31/03/2019

  Project: Research

• Stratified medicine for cognition in schizophrenia: A proof of concept study on therapeutic response to a7 nicotinic receptor agonists

  Kapur, S. (Primary Investigator) & Michalopoulou, P. (Co-Investigator)

  1/04/2015 → 30/09/2016

  Project: Research

• A stratified medicine approach for cognition in schizophrenia: A proof of concept study on therapeutic response to a7 nicotinic receptor agonists

  Michalopoulou, P. (Primary Investigator), Kapur, S. (Co-Investigator) & Williams, S. (Co-Investigator)

  1/01/2015 → 31/12/2018

  Project: Research

• STRATA - Schizophrenia: Treatment Resistance and Therapeutic Advances

  Maccabe, J. (Primary Investigator), Barker, G. (Co-Investigator), Egerton, A. (Co-Investigator), Howes, O. (Co-Investigator), Kapur, S. (Co-Investigator), Lythgoe, D. (Co-Investigator), McCrone, P. (Co-Investigator), McGuire, P. (Co-Investigator), Murray, R. (Co-Investigator), Pickles, A. (Co-Investigator), Rose, D. (Co-Investigator) & Stone, J. (Co-Investigator)

  MRC Medical Research Council

  1/10/2014 → 31/12/2019

  Project: Research

• STRATA - Schizophrenia: Treatment Resistance and Therapeutic Advances

  Maccabe, J. (Primary Investigator), Barker, G. (Co-Investigator), Egerton, A. (Co-Investigator), Howes, O. (Co-Investigator), Kapur, S. (Co-Investigator), Lythgoe, D. (Co-Investigator), McCrone, P. (Co-Investigator), McGuire, P. (Co-Investigator), Murray, R. (Co-Investigator), Pickles, A. (Co-Investigator), Rose, D. (Co-Investigator) & Stone, J. (Co-Investigator)

  MRC Medical Research Council

  1/10/2014 → 30/09/2019

  Project: Research

• Beyond dopamine receptors in schizophrenia - evaluating the role of phosphodiesterase 10A in disease and treatment using PET imaging

  Kapur, S. (Primary Investigator), Howes, O. (Co-Investigator), Natesan, S. (Co-Investigator), Rabiner, E. (Co-Investigator) & Reis Marques, T. (Co-Investigator)

  MRC Medical Research Council

  30/06/2014 → 29/06/2017

  Project: Research

• Beyond dopamine in Schizophrenia - evaluating the role of Phosphodiesterase 10A using PET imaging

  Reis Marques, T. (Primary Investigator), Howes, O. (Co-Investigator) & Kapur, S. (Co-Investigator)

  1/04/2014 → 1/04/2017

  Project: Research

• Dissecting brain inflammation in depression : Integrating behaviour,PET,MRS,MRI,cytokines and transcriptomics

  Pariante, C. (Primary Investigator), Barker, G. (Co-Investigator), Cleare, A. (Co-Investigator), Dazzan, P. (Co-Investigator), Dobson, R. (Co-Investigator), Hayday, A. (Co-Investigator), Hotopf, M. (Co-Investigator), Howes, O. (Co-Investigator), Kapur, S. (Co-Investigator), Pickles, A. (Co-Investigator), Rabiner, E. (Co-Investigator), Taylor, M. (Co-Investigator), Turkheimer, F. (Co-Investigator) & Tylee, A. (Co-Investigator)

  1/10/2013 → 30/09/2016

  Project: Research

• Does inflammation cause depressed mood by inducing changes in brain structure? Developing a translational animal model

  Vernon, A. (Primary Investigator), Kapur, S. (Co-Investigator), So, P.-W. (Co-Investigator) & Thuret, S. (Co-Investigator)

  Psychiatry Research Trust

  1/05/2013 → 31/12/2015

  Project: Research

• Determining the pathophysiology of poor treatment response in schizophrenia to guide the development of new treatments

  Jauhar, S. (Primary Investigator), Howes, O. (Co-Investigator) & Kapur, S. (Co-Investigator)

  4/02/2013 → 1/02/2016

  Project: Research

• MICA: Personalised monitoring and enhanced self-management in mental health (CareLoop)

  Wykes, T. (Primary Investigator), Kapur, S. (Co-Investigator) & Tarrier, N. (Co-Investigator)

  MRC Medical Research Council

  1/02/2013 → 30/07/2015

  Project: Research

• MICA: Personalised monitoring and enhanced self-management in mental health (CareLoop)

  Wykes, T. (Primary Investigator), Kapur, S. (Co-Investigator) & Tarrier, N. (Co-Investigator)

  MRC Medical Research Council

  1/02/2013 → 31/10/2015

  Project: Research

• Predicting drug response in schizophrenia: are clinical & cognitive tests a cost-effective alternative to neuroimaging?

  Mechelli, A. (Primary Investigator), Brammer, M. (Co-Investigator), Dazzan, P. (Co-Investigator), Kapur, S. (Co-Investigator) & McGuire, P. (Co-Investigator)

  MRC Medical Research Council

  1/01/2013 → 31/12/2014

  Project: Research

• Treatment refractory schizophrenia : building networks and elucidating mechanisms for a Stratified Medicine approach (aka STRATA)

  Kapur, S. (Primary Investigator), Maccabe, J. (Co-Investigator) & Rose, D. (Co-Investigator)

  MRC Medical Research Council

  1/10/2012 → 31/03/2013

  Project: Research

• Improving Cognition in Schizophrenia using phramacologically-enhanced cogniive training

  Gilleen, J. (Primary Investigator), Kapur, S. (Co-Investigator), Michalopoulou, P. (Co-Investigator) & Reichenberg, A. (Co-Investigator)

  1/09/2012 → 31/08/2015

  Project: Research

• Effects of essential fatty acid supplementation in a neurondevelopmental model of Schizophrenia

  Vernon, A. (Primary Investigator), Kapur, S. (Co-Investigator), So, P.-W. (Co-Investigator) & Williams, S. (Co-Investigator)

  15/07/2012 → 15/07/2013

  Project: Research

• A double-blind, placebo-controlled study on the effects of combined L-Carnosine and cognitive training on cognition in schizophrenia

  Reichenberg, A. (Primary Investigator), Gilleen, J. (Co-Investigator), Kapur, S. (Co-Investigator) & Michalopoulou, P. (Co-Investigator)

  Stanley Medical Research Institute

  15/05/2012 → 14/05/2015

  Project: Research

• Biomedical Research Centre for Mental Health - EMCT Cluster - Clinical Trials

  Kapur, S. (Primary Investigator)

  NIHR National Institute For Health & Care Research

  1/04/2012 → 31/07/2013

  Project: Research

• Cannabidiol as a novel early therapy in psychotic disorders study 1 non-CTIMP (n=20), Study 2 trial (n=40)

  Kapur, S. (Primary Investigator), McGuire, P. (Co-Investigator), Morrison, P. (Co-Investigator), Murray, R. (Co-Investigator), Pickles, A. (Co-Investigator) & Valmaggia, L. (Co-Investigator)

  1/04/2012 → 1/04/2015

  Project: Research

• Neurobiological determinants of treatment response in psychosis

  Howes, O. (Primary Investigator), Dazzan, P. (Co-Investigator), Egerton, A. (Co-Investigator), Kapur, S. (Co-Investigator) & McGuire, P. (Co-Investigator)

  Wellcome Trust

  5/03/2012 → 31/08/2017

  Project: Research

• A double-blind, placebo-controlled, longitudinal study into the synergistic effect of combination Glycine Transporter Inhibitor plus cognitive remediation training program on cornitive deficits in schizophrenia

  Reichenberg, A. (Primary Investigator), Kapur, S. (Co-Investigator) & Michalopoulou, P. (Co-Investigator)

  1/03/2012 → 1/03/2014

  Project: Research

• Effect of chronic antipsychotic drug treatment on rodent brain structure

  Vernon, A. (Primary Investigator) & Kapur, S. (Co-Investigator)

  8/01/2012 → 9/01/2015

  Project: Research

• A study improvig cognition in shizophrenia using cognitive training and non-invasive brain stimulation

  Shergill, S. (Primary Investigator), Kapur, S. (Co-Investigator) & Michalopoulou, P. (Co-Investigator)

  2/01/2012 → 31/01/2014

  Project: Research

• A Multicentre Longitudinal Study of Changes in Brian Structure in First Episode Psychosis: Relationship to Medication and Clinical Outcome

  Mechelli, A. (Primary Investigator), Barker, G. (Co-Investigator), Dazzan, P. (Co-Investigator), Kapur, S. (Co-Investigator) & McGuire, P. (Co-Investigator)

  1/01/2012 → 31/12/2016

  Project: Research

• Neurobiological factors underlying the onset of psychosis.

  McGuire, P. (Primary Investigator), DO NOT USE, P. (Co-Investigator), Howes, O. (Co-Investigator), Kapur, S. (Co-Investigator), Mechelli, A. (Co-Investigator), Stone, J. (Co-Investigator) & Williams, S. (Co-Investigator)

  Wellcome Trust

  1/09/2011 → 28/02/2017

  Project: Research

• Effects of antipsychotics: linking brain structural imaging changes to cellular alterations and evaluating mitigation strategies.

  Kapur, S. (Primary Investigator), Cooper, J. (Co-Investigator), Vernon, A. (Co-Investigator) & Williams, S. (Co-Investigator)

  MRC Medical Research Council

  1/08/2011 → 31/01/2015

  Project: Research

• Early Brain Damage Leading to Dopamine Dysregulation - Testing a Cardinal Neurodevelopmental Hypothesis of Psychiatric Illness

  Nosarti, C. (Primary Investigator), Froudist Walsh, S. (Co-Investigator), Howes, O. (Co-Investigator), Kapur, S. (Co-Investigator) & Williams, S. (Co-Investigator)

  March of Dimes

  1/06/2011 → 28/02/2015

  Project: Research

• Augmentation of Cognitive Behaviour Therapy for Psychosis with D-serine

  Kumari, V. (Primary Investigator), Johns, L. (Co-Investigator), Kapur, S. (Co-Investigator), Kuipers, E. (Co-Investigator) & Peters, E. (Co-Investigator)

  1/05/2011 → 30/04/2015

  Project: Research

• Levodopa as an add-on treatment for enhancing cognitive performance in schizophrenia: A randomised, controlled, pilot clinical trial

  Kapur, S. (Primary Investigator), Michalopoulou, P. (Co-Investigator) & Shergill, S. (Co-Investigator)

  1/04/2011 → 31/03/2013

  Project: Research

• Optimisation of Treatment and Management of Schizophrenia in Europe

  McGuire, P. (Primary Investigator), Barker, G. (Co-Investigator), Collier, D. (Co-Investigator), Dazzan, P. (Co-Investigator) & Kapur, S. (Co-Investigator)

  EC European Commission

  1/09/2010 → 31/08/2016

  Project: Research

• Levodopa as an add-on treatment for enhancing cognitive performance in schizophrenia: a randomised, controlled, clinical trial.

  Kapur, S. (Primary Investigator) & Shergill, S. (Co-Investigator)

  1/09/2010 → 31/08/2013

  Project: Research

• Understanding post-receptor mechanisms of antipsychotic action

  Arranz, M. (Primary Investigator), Fernandes, C. (Co-Investigator), Kapur, S. (Co-Investigator) & Natesan, S. (Co-Investigator)

  1/07/2010 → 30/06/2013

  Project: Research

• How antipsychotics work and why they fail - understanding the dynamics of antipsychotic action

  Muller, C. (Primary Investigator), Kapur, S. (Co-Investigator) & Natesan, S. (Co-Investigator)

  1/07/2010 → 30/06/2013

  Project: Research

• Effects of antipsychotics on brain structure - linking structural imaging changes to cellular alterations.

  Kapur, S. (Primary Investigator), Modo, M. (Co-Investigator) & Williams, S. (Co-Investigator)

  1/05/2010 → 30/04/2013

  Project: Research

• Pet study of dopaminergic activity in treatment resistant schizophrenia

  Demjaha, A. (Primary Investigator), Howes, O. (Co-Investigator), Kapur, S. (Co-Investigator) & Murray, R. (Co-Investigator)

  1/04/2010 → 31/03/2013

  Project: Research

• Optimising Individualised prescribing with therapeutic drug Monitoring for Antipsychotics (OptIMA)

  Patel, M. (Primary Investigator), David, A. (Co-Investigator) & Kapur, S. (Co-Investigator)

  NIHR National Institute For Health & Care Research

  1/03/2010 → 28/02/2015

  Project: Research

• Novel Methods leading to New Medications in Depression and Schizophrenia (NEWMEDS)

  Kapur, S. (Primary Investigator), Brammer, M. (Co-Investigator), McGuffin, P. (Co-Investigator), Mehta, M. (Co-Investigator), Reichenberg, A. (Co-Investigator), Shergill, S. (Co-Investigator) & Uher, R. (Co-Investigator)

  EC European Commission

  1/09/2009 → 28/02/2015

  Project: Research

• "Will the voices come back, doc?" - A study predicting future relapses in schizophrenia

  Dazzan, P. (Co-Investigator), Kapur, S. (Co-Investigator), Murray, R. (Co-Investigator), Pariante, C. (Co-Investigator) & Williams, S. (Co-Investigator)

  1/01/2009 → 31/12/2011

  Project: Research

• Predicting treatment response in Schizophrenia

  Aitchison, K. (Co-Investigator), Arranz, M. (Co-Investigator), Barker, G. (Co-Investigator), Collier, D. (Co-Investigator), Dazzan, P. (Co-Investigator), Di Forti, M. (Co-Investigator), Kapur, S. (Co-Investigator), Landau, S. (Co-Investigator), Lovestone, S. (Co-Investigator), McGuffin, P. (Co-Investigator), Mondelli, V. (Co-Investigator), Murray, R. (Co-Investigator), Pariante, C. (Co-Investigator) & Simmons, A. (Co-Investigator)

  1/09/2008 → 31/08/2013

  Project: Research

• Good and poor responders to Clozapine for Treatment Refractory Schizophrenia (C4TRS)

  David, A. (Co-Investigator), Kapur, S. (Co-Investigator), Murray, R. (Co-Investigator) & Patel, M. (Co-Investigator)

  1/07/2008 → 31/12/2010

  Project: Research

• Establishing early neuroimaging biomarkers to predict treatment response in Schizophrenia

  Dazzan, P. (Co-Investigator), Kapur, S. (Co-Investigator), Landau, S. (Co-Investigator), Murray, R. (Co-Investigator), Pariante, C. (Co-Investigator) & Simmons, A. (Co-Investigator)

  King's College London (KCL)

  1/05/2008 → 31/12/2010

  Project: Research

• Strategic Appointment Award

  Kapur, S. (Primary Investigator)

  MRC Medical Research Council

  29/01/2008 → 28/01/2012

  Project: Research