Determining the molecular mechanisms underlying IL-10 expression in human CD4+ T-cells following TNF blockade

Taams, Leonie (Primary Investigator)
Dionne, Marc (Co-Investigator)
Lavender, Paul (Co-Investigator)

Peter Gorer Department of Immunobiology

Project: Research

Status	Finished
Effective start/end date	1/04/2016 → 31/07/2023

Funding

Arthritis Research UK: £1,185,430.00

UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This project contributes towards the following SDG(s):

5 Article

Identification of a transcription factor network regulating anti-TNF mediated IL10 expression in human CD4+ T cells
Povoleri, G., Ridley, M., Marrow, R., Lalnunhlimi, S., Ryan, S., Kelly, A., Lavender, P. & Taams, L., 27 Jul 2024, In: Discovery Immunology. 3, 1, kyae013.
Research output: Contribution to journal › Article › peer-review

Open Access
miR-155 overexpressing monocytes resemble HLAhighISG15+ synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T cell activation
Olsson, B. A., Povoleri, G., Somma, D., Ridley, M., Rizou, T., Lalnunhlimi, S., Macdonald, L., Rajasekhar, M., Martinez Nunez, R., Kurowska-Stolarska, M. & Taams, L., 30 Nov 2021, (E-pub ahead of print) In: Clinical and Expentmental Immunology.
Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus)
Anti-TNF treatment negatively regulates human CD4+ T-cell activation and maturation in vitro, but does not confer an anergic or suppressive phenotype
Povoleri, G. A. M., Lalnunhlimi, S., Steel, K. J. A., Agrawal, S., O'Byrne, A., Ridley, M., Kordasti, S., Frederiksen, K. S., Roberts, C. A. & Taams, L. S., Mar 2020, In: European Journal of Immunology. 50, 3, p. 445-458 14 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
19 Citations (Scopus)

163 Downloads (Pure)

1 Participation in conference

Annual European Congress of rheumatology (EULAR 2020)
Taams, L. (Invited speaker)
3 Jun 2020 → 6 Jun 2020
Activity: Participating in or organising an event › Participation in conference

Determining the molecular mechanisms underlying IL-10 expression in human CD4+ T-cells following TNF blockade

Project Details

Funding

UN Sustainable Development Goals

Fingerprint

Identification of a transcription factor network regulating anti-TNF mediated IL10 expression in human CD4+ T cells

miR-155 overexpressing monocytes resemble HLAhighISG15+ synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T cell activation

Anti-TNF treatment negatively regulates human CD4+ T-cell activation and maturation in vitro, but does not confer an anergic or suppressive phenotype

Annual European Congress of rheumatology (EULAR 2020)

Determining the molecular mechanisms underlying IL-10 expression in human CD4+ T-cells following TNF blockade

Project Details

Funding

UN Sustainable Development Goals

Fingerprint

Research output

Identification of a transcription factor network regulating anti-TNF mediated IL10 expression in human CD4+ T cells

miR-155 overexpressing monocytes resemble HLAhighISG15+ synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T cell activation

Anti-TNF treatment negatively regulates human CD4+ T-cell activation and maturation in vitro, but does not confer an anergic or suppressive phenotype

Activities

Annual European Congress of rheumatology (EULAR 2020)