Projects per year
Abstract
MicroRNAs (miRs) are known to regulate pro-inflammatory effector functions of myeloid cells, and miR dysregulation is implicated in rheumatoid arthritis (RA), a condition characterised by inflammation and destruction of the joints. We showed previously that miR-155 is increased in myeloid cells in RA and induces pro-inflammatory activation of monocytes and macrophages, however its role at the interface between innate and adaptive immunity was not defined. Here, RNA-sequencing revealed that overexpression of miR-155 in healthy donor monocytes conferred a specific gene profile which bears similarities to that of RA synovial fluid-derived CD14+ cells and HLAhighISG15+ synovial tissue macrophages, both of which are characterised by antigen presenting pathways. In line with this, monocytes in which miR-155 was overexpressed, displayed increased expression of HLA-DR and both co-stimulatory and co-inhibitory molecules, and induced activation of polyfunctional T cells. Together, these data underpin the notion that miR-155-driven myeloid cell activation in the synovium contributes not only to inflammation but may also influence the adaptive immune response.
| Original language | English |
|---|---|
| Journal | Clinical and Expentmental Immunology |
| Early online date | 30 Nov 2021 |
| DOIs | |
| Publication status | E-pub ahead of print - 30 Nov 2021 |
Keywords
- microRNA
- IL-10
- innate immunity
- immune regulation
- monocyte
Fingerprint
Dive into the research topics of 'miR-155 overexpressing monocytes resemble HLAhighISG15+ synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T cell activation'. Together they form a unique fingerprint.Projects
- 3 Finished
-
Determining the molecular mechanisms underlying IL-10 expression in human CD4+ T-cells following TNF blockade
Taams, L. (Primary Investigator), Dionne, M. (Co-Investigator) & Lavender, P. (Co-Investigator)
1/04/2016 → 31/07/2023
Project: Research
-
Investigating the role of miRNAs in inflammatory arthritis
Taams, L. (Primary Investigator) & Guermonprez, P. (Co-Investigator)
1/10/2015 → 30/09/2019
Project: Research
-
NIHR Biomedical Research Centre
Afzali, B. (Primary Investigator), Antoniou, M. (Primary Investigator), Barker, J. (Primary Investigator), Barratt, B. (Primary Investigator), Beighton, D. (Primary Investigator), Bevan, S. (Primary Investigator), Blower, P. (Primary Investigator), Burchell, J. (Primary Investigator), Cason, J. (Primary Investigator), Chappell, L. (Primary Investigator), Cope, A. (Primary Investigator), Corrigan, C. (Primary Investigator), Cunninghame Graham, D. (Primary Investigator), Dontu, G. (Primary Investigator), Edgeworth, J. (Primary Investigator), Farzaneh, F. (Primary Investigator), Gee, T. (Primary Investigator), Gould, H. (Primary Investigator), Green, P. (Primary Investigator), Greenough, A. (Primary Investigator), Grigoriadis, A. (Primary Investigator), Hayday, A. (Primary Investigator), Higginson, I. (Primary Investigator), Kalra, L. (Primary Investigator), Karagiannis, S. (Primary Investigator), Kelly, F. (Primary Investigator), Kemper, C. (Primary Investigator), Lau-Walker, M. (Primary Investigator), Lavender, P. (Primary Investigator), Lee, T. (Primary Investigator), Lempp, H. (Primary Investigator), Lewis, C. (Primary Investigator), Lombardi, G. (Primary Investigator), Lord, G. (Primary Investigator), Marber, M. (Primary Investigator), Mason, J. (Primary Investigator), Mathew, C. (Primary Investigator), McGrath, J. (Primary Investigator), Metcalfe, A. (Primary Investigator), Molokhia, M. (Primary Investigator), Mullen, G. (Primary Investigator), Nagel, E. (Primary Investigator), Neil, S. (Primary Investigator), Nestle, F. (Primary Investigator), Oakey, R. (Primary Investigator), Parker, P. (Primary Investigator), Peakman, M. (Primary Investigator), Perera, D. (Primary Investigator), Purushotham, A. (Primary Investigator), Rasekh Ahmadi, K. (Primary Investigator), Rashid, T. (Primary Investigator), Razavi, R. (Primary Investigator), Ridley, A. (Primary Investigator), Robson, M. (Primary Investigator), Sacks, S. (Primary Investigator), Sanchez Fueyo, A. (Primary Investigator), Santis, G. (Primary Investigator), Sanz Moreno, V. (Primary Investigator), Sawyer, E. (Primary Investigator), Schaeffter, T. (Primary Investigator), Shah, A. (Primary Investigator), Sharpe, P. (Primary Investigator), Simpson, M. (Primary Investigator), Smith, R. (Primary Investigator), Sorinola, I. (Primary Investigator), Spector, T. (Primary Investigator), Spicer, J. (Primary Investigator), Taams, L. (Primary Investigator), Tavassoli, M. (Primary Investigator), Taylor, D. (Primary Investigator), Tree, T. (Primary Investigator), Trembath, R. (Primary Investigator), Tribe, R. (Primary Investigator), Tutt, A. (Primary Investigator), Waltham, M. (Primary Investigator), Watt, F. (Primary Investigator), Webb, A. (Primary Investigator), Wells, C. (Primary Investigator), Whelan, K. (Primary Investigator), Whitaker, J. (Primary Investigator), Whittlesea, C. (Primary Investigator), Williamson, C. (Primary Investigator), Wolfe, C. (Primary Investigator), Yu, V. (Primary Investigator), academic, A. (Primary Investigator), Hughes, S. (Co-Investigator), Montana, G. (Co-Investigator), Rhode, K. (Co-Investigator), Schnabel, J. (Co-Investigator) & Tziotzios, C. (Co-Investigator)
NIHR National Institute For Health & Care Research, DHSC Department of Health and Social Care
1/04/2007 → 31/03/2017
Project: Research
Research output
- 8 Citations
- 1 Article
-
MicroRNA-155 contributes to enhanced resistance to apoptosis in monocytes from patients with rheumatoid arthritis
Rajasekhar, M., Olsson, A. M., Steel, K. J. A., Georgouli, M., Ranasinghe, U., Brender Read, C., Frederiksen, K. S. & Taams, L. S., 31 May 2017, In: Journal of Autoimmunity. 79, p. 53-62 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile77 Citations (Scopus)272 Downloads (Pure)
Student theses
-
Investigating the pro-and anti-inflammatory roles of miR-155 and miR-210 in CD14+ monocytes
Olsson, A. (Author), Taams, L. (Supervisor), 1 Feb 2021Student thesis: Doctoral Thesis › Doctor of Philosophy