TY - JOUR
T1 - Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
AU - The Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
AU - Wray, Naomi R.
AU - Ripke, Stephan
AU - Mattheisen, Manuel
AU - Trzaskowski, Maciej
AU - Byrne, Enda M.
AU - Abdellaoui, Abdel
AU - Adams, Mark J.
AU - Agerbo, Esben
AU - Air, Tracy M.
AU - Andlauer, Till M. F.
AU - Bacanu, Silviu-Alin
AU - Bækvad-Hansen, Marie
AU - Beekman, Aartjan F. T.
AU - Bigdeli, Tim B.
AU - Binder, Elisabeth B.
AU - Blackwood, Douglas R. H.
AU - Bryois, Julien
AU - Buttenschøn, Henriette N.
AU - Bybjerg-Grauholm, Jonas
AU - Cai, Na
AU - Castelao, Enrique
AU - Christensen, Jane Hvarregaard
AU - Clarke, Toni-kim
AU - Coleman, Jonathan I. R.
AU - Colodro-Conde, Lucía
AU - Couvy-Duchesne, Baptiste
AU - Craddock, Nick
AU - Crawford, Gregory E.
AU - Crowley, Cheynna A.
AU - Dashti, Hassan S.
AU - Davies, Gail
AU - Deary, Ian J.
AU - Degenhardt, Franziska
AU - Derks, Eske M.
AU - Direk, Nese
AU - Eley, Thalia C.
AU - Gaspar, Héléna A.
AU - Hansen, Thomas F.
AU - Li, Yun
AU - Mcguffin, Peter
AU - Mill, Jonathan
AU - Mullins, Niamh
AU - Purcell, Shaun M.
AU - Riley, Brien P.
AU - Smith, Daniel J.
AU - Tansey, Katherine E.
AU - Traylor, Matthew
AU - Uher, Rudolf
AU - Lewis, Cathryn M.
AU - Breen, Gerome
AU - O'Reilly, Paul F.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association (GWA) meta-analysis based in 135,458 cases and 344,901 controls. We identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression, and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relations of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine and define the basis of major depression and imply a continuous measure of risk underlies the clinical phenotype.
AB - Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association (GWA) meta-analysis based in 135,458 cases and 344,901 controls. We identified 44 independent and significant loci. The genetic findings were associated with clinical features of major depression, and implicated brain regions exhibiting anatomical differences in cases. Targets of antidepressant medications and genes involved in gene splicing were enriched for smaller association signal. We found important relations of genetic risk for major depression with educational attainment, body mass, and schizophrenia: lower educational attainment and higher body mass were putatively causal whereas major depression and schizophrenia reflected a partly shared biological etiology. All humans carry lesser or greater numbers of genetic risk factors for major depression. These findings help refine and define the basis of major depression and imply a continuous measure of risk underlies the clinical phenotype.
U2 - 10.1038/s41588-018-0090-3
DO - 10.1038/s41588-018-0090-3
M3 - Article
SN - 1061-4036
VL - 50
SP - 668
EP - 681
JO - Nature Genetics
JF - Nature Genetics
IS - 5
ER -
