TY - JOUR
T1 - Synthesis, Characterization, and Application of Core–Shell Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm) Nanoparticle as Trimodal (MRI, PET/SPECT, and Optical) Imaging Agents
AU - Cui, Xianjin
AU - Mathe, Domokos
AU - Kovács, Noémi
AU - Horváth, Ildikó
AU - Jauregui-Osoro, Maite
AU - Torres Martin de Rosales, Rafael
AU - Mullen, Gregory E. D.
AU - Wong, Wilson
AU - Yan, Yong
AU - Krüger, Dirk
AU - Khlobystov, Andrei N.
AU - Gimenez-Lopez, Maria
AU - Semjeni, Mariann
AU - Szigeti, Krisztián
AU - Veres, Dániel S
AU - Lu, Haizhou
AU - Hernández, Ignacio
AU - Gillin, William P.
AU - Protti, Andrea
AU - Petik, Katalin Kis
AU - Green, Mark A.
AU - Blower, Philip J.
N1 - doi: 10.1021/acs.bioconjchem.5b00338
PY - 2016/2/17
Y1 - 2016/2/17
N2 - Multimodal nanoparticulate materials are described, offering magnetic, radionuclide, and fluorescent imaging capabilities to exploit the complementary advantages of magnetic resonance imaging (MRI), positron emission tomography/single-photon emission commuted tomography (PET/SPECT), and optical imaging. They comprise Fe3O4@NaYF4 core/shell nanoparticles (NPs) with different cation dopants in the shell or core, including Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm). These NPs are stabilized by bisphosphonate polyethylene glycol conjugates (BP-PEG), and then show a high transverse relaxivity (r2) up to 326 mM–1 s–1 at 3T, a high affinity to [18F]-fluoride or radiometal-bisphosphonate conjugates (e.g., 64Cu and 99mTc), and fluorescent emissions from 500 to 800 nm under excitation at 980 nm. The biodistribution of intravenously administered particles determined by PET/MR imaging suggests that negatively charged Co0.16Fe2.84O4@NaYF4(Yb, Er)-BP-PEG (10K) NPs cleared from the blood pool more slowly than positively charged NPs Fe3O4@NaYF4(Yb, Tm)-BP-PEG (2K). Preliminary results in sentinel lymph node imaging in mice indicate the advantages of multimodal imaging.
AB - Multimodal nanoparticulate materials are described, offering magnetic, radionuclide, and fluorescent imaging capabilities to exploit the complementary advantages of magnetic resonance imaging (MRI), positron emission tomography/single-photon emission commuted tomography (PET/SPECT), and optical imaging. They comprise Fe3O4@NaYF4 core/shell nanoparticles (NPs) with different cation dopants in the shell or core, including Co0.16Fe2.84O4@NaYF4(Yb, Er) and Fe3O4@NaYF4(Yb, Tm). These NPs are stabilized by bisphosphonate polyethylene glycol conjugates (BP-PEG), and then show a high transverse relaxivity (r2) up to 326 mM–1 s–1 at 3T, a high affinity to [18F]-fluoride or radiometal-bisphosphonate conjugates (e.g., 64Cu and 99mTc), and fluorescent emissions from 500 to 800 nm under excitation at 980 nm. The biodistribution of intravenously administered particles determined by PET/MR imaging suggests that negatively charged Co0.16Fe2.84O4@NaYF4(Yb, Er)-BP-PEG (10K) NPs cleared from the blood pool more slowly than positively charged NPs Fe3O4@NaYF4(Yb, Tm)-BP-PEG (2K). Preliminary results in sentinel lymph node imaging in mice indicate the advantages of multimodal imaging.
U2 - 10.1021/acs.bioconjchem.5b00338
DO - 10.1021/acs.bioconjchem.5b00338
M3 - Article
SN - 1043-1802
VL - 27
SP - 319
EP - 328
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
IS - 2
ER -