Projects per year
Projects
- 49 Finished
Search results
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Finished
Does COVID-19 affect the brain? Gaining mechanistic insight “in vitro” on how brain cell function is disrupted upon exposure to serum from COVID-19 patients with neurological symptoms
Borsini, A. (Primary Investigator), Lechler, R. (Co-Investigator), Pariante, C. (Co-Investigator), Srivastava, D. (Co-Investigator), Thuret, S. (Co-Investigator), Vernon, A. (Co-Investigator) & Williams, F. (Co-Investigator)
1/02/2021 → 31/08/2022
Project: Research
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Targeting Nox2 to improve regulatory T cell function and immune tolerance in heart transplantation
Shah, A. (Primary Investigator), Cellone Trevelin, S. (Co-Investigator), Lombardi, G. (Co-Investigator), Ivetic, A. (Co-Investigator) & Lechler, R. (Co-Investigator)
10/08/2018 → 9/08/2021
Project: Research
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Targeting recipient antigen-presenting cells with sialic acid-modified alloantigen to promote transplantation tolerance
Lombardi, G. (Primary Investigator), Lechler, R. (Co-Investigator) & Smyth, L. A. (Co-Investigator)
1/10/2017 → 30/09/2020
Project: Research
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Defining the mechanisms underlying the role of regulatory T cells in the establishment of tolerance
Lombardi, G. (Primary Investigator), Sanchez Fueyo, A. (Primary Investigator), Douiri, A. (Co-Investigator), Lechler, R. (Co-Investigator) & Martinez-Llordella, M. (Co-Investigator)
9/01/2017 → 8/01/2022
Project: Research
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Thymus derived Tregs expanded in vitro as a treatment for paediatric heart transplant patients to prevent cardiac allograft vasculopathy.
Lombardi, G. (Primary Investigator), Botnar, R. (Co-Investigator), Lechler, R. (Co-Investigator) & Scotta, C. (Co-Investigator)
1/01/2017 → 31/12/2018
Project: Research
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Defining the mechanisms underlying the role of regulatory t cells in the establishment of tolerance
Lombardi, G. (Primary Investigator), Lechler, R. (Co-Investigator), Martinez-Llordella, M. (Co-Investigator), Rebollo-Mesa, I. (Co-Investigator) & Sanchez Fueyo, A. (Co-Investigator)
1/06/2016 → 31/05/2021
Project: Research
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Preclinical assessment of targeting DCs directly in vivo to prevent human islet transplant rejection as a cure for Type 1 diabetes
Lombardi, G. (Primary Investigator), Huang, G. (Co-Investigator), Jones, P. (Co-Investigator), Lechler, R. (Co-Investigator) & Xiao, F. (Co-Investigator)
1/01/2016 → 31/12/2018
Project: Research
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Preclinical assessment of targeting DCs directly in vivo to prevent human islet transplant rejection as a cure for Type 1 diabetes
Lombardi, G. (Primary Investigator), Huang, G. (Co-Investigator), Jones, P. (Co-Investigator), Lechler, R. (Co-Investigator) & Xiao, F. (Co-Investigator)
1/01/2016 → 31/12/2018
Project: Research
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Preclinical assessment of targeting DCs directly in vivo to prevent human islettransplant rejection as a cure for Type 1 diabetes
Lombardi, G. (Primary Investigator), Huang, G. (Co-Investigator), Jones, P. (Co-Investigator), Lechler, R. (Co-Investigator) & Xiao, F. (Co-Investigator)
1/01/2016 → 31/12/2018
Project: Research
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Using biomarkers of tolerance to guide immunosuppression weaning in kidney transplant recipients
Hernandez Fuentes, M. (Primary Investigator), Lechler, R. (Co-Investigator), Lord, G. (Co-Investigator) & Rebollo-Mesa, I. (Co-Investigator)
1/01/2014 → 31/12/2018
Project: Research
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Optimising the efficacy of regulatory T cells: informing clinical application
Lombardi, G. (Primary Investigator) & Lechler, R. (Co-Investigator)
1/10/2013 → 30/09/2018
Project: Research
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ThRIL: a 'first-in-human' study, evaluating the safety, tolerability with an investigation into the efficacy of Tregs in liver transplant recipients
Lombardi, G. (Primary Investigator), Aluvihare, V. (Co-Investigator), Heaton, N. (Co-Investigator), Lechler, R. (Co-Investigator), Peacock, J. (Co-Investigator), Rebollo-Mesa, I. (Co-Investigator), Safinia, N. (Co-Investigator), Sanchez Fueyo, A. (Co-Investigator) & Wang, Y. (Co-Investigator)
31/08/2013 → 29/06/2018
Project: Research
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Developmental Clinical Study: using Biomarkers of tolerance to guide immunosupression weaning in kidney transplant recipients.
Hernandez Fuentes, M. (Primary Investigator), Lechler, R. (Co-Investigator), Lord, G. (Co-Investigator) & Rebollo-Mesa, I. (Co-Investigator)
1/01/2013 → 31/12/2017
Project: Research
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Preclinical in vivo assessment of a combination of protein and cell therapies to prevent human islet transplant rejection as a cure for Type 1 diabetes
Lombardi, G. (Primary Investigator), Dorling, A. (Co-Investigator), Huang, G. (Co-Investigator), Lechler, R. (Co-Investigator) & Xiao, F. (Co-Investigator)
1/12/2012 → 31/12/2015
Project: Research
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The relevance of regulatory T cell conversion to T helper 17 for the balance between tolerance and inflammation
Afzali, B. (Primary Investigator), Lechler, R. (Primary Investigator) & O'Shea, J. (Co-Investigator)
1/10/2012 → 4/11/2017
Project: Research
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Dissecting regulatory T Cell subset functions in vivo using cell imaging techniques
Lombardi, G. (Primary Investigator), Lechler, R. (Co-Investigator) & Mullen, G. (Co-Investigator)
1/05/2012 → 1/05/2015
Project: Research
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Pre clinical in vivo assessment of cell therapy to prevent human islet transplant rejection to cure Type 1 diabetes
Lombardi, G. (Primary Investigator), Dorling, A. (Co-Investigator), Huang, G. (Co-Investigator) & Lechler, R. (Co-Investigator)
1/01/2012 → 31/12/2014
Project: Research
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Use of chimeric antigen receptor-engineered Tregs to elicit targeted transplantation tolerance
Lombardi, G. (Primary Investigator), Maher, J. (Primary Investigator) & Lechler, R. (Co-Investigator)
1/10/2011 → 30/09/2014
Project: Research
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Role of B cells in the amplification and regulation of transplant rejection
Lechler, R. (Primary Investigator), Lombardi, G. (Primary Investigator) & Noelle, R. (Co-Investigator)
1/10/2011 → 30/09/2014
Project: Research
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Dissecting regulatory T cell functions using cell imagingtechniques
Lombardi, G. (Primary Investigator), Lechler, R. (Co-Investigator), Mullen, G. (Co-Investigator) & academic, A. (Co-Investigator)
1/03/2011 → 28/02/2014
Project: Research
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The ONE Study: a unified approach to evaluating cellular immunotherapy in solid organ transplantation
Lombardi, G. (Primary Investigator), Hernandez Fuentes, M. (Co-Investigator), Lechler, R. (Co-Investigator) & Noelle, R. (Co-Investigator)
1/10/2010 → 31/10/2017
Project: Research
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Evaluating the immunological consequences of intercellular MHC transfer using immunotoxin
Wong, W. (Primary Investigator), Lechler, R. (Co-Investigator), Lombardi, G. (Co-Investigator) & Smith, R. (Co-Investigator)
1/04/2010 → 31/03/2013
Project: Research
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Optimising expansion and culture of regulatory T-cells to develop safe and effective cellular therapeutics for clinical transplantation and autoimmunity
Lechler, R. (Primary Investigator), Lombardi, G. (Primary Investigator), Noelle, R. (Primary Investigator), Kemper, C. (Co-Investigator), Marelli-Berg, F. (Co-Investigator) & Nestle, F. (Co-Investigator)
1/03/2010 → 31/05/2012
Project: Research
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Dissecting regulatory T cell functions using cell imaging techniques
Lombardi, G. (Primary Investigator), Mullen, G. (Primary Investigator), Smyth, L. (Primary Investigator), Lechler, R. (Co-Investigator), Ng, T. (Co-Investigator) & Ridley, A. (Co-Investigator)
1/10/2009 → 30/09/2012
Project: Research
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Driving Sino-UK innovation in regenerative medicine
Salter, B. (Primary Investigator), Hylands, P. (Co-Investigator), Lechler, R. (Co-Investigator), Mann, G. (Co-Investigator) & Minger, S. (Co-Investigator)
1/01/2009 → 31/12/2011
Project: Research
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Biomarkers of clinical transplantation tolerance. GAMBIT study
Hernandez Fuentes, M. (Primary Investigator), Lechler, R. (Primary Investigator), Lord, G. (Primary Investigator), Seyfert-Margolis, V. (Co-Investigator) & Turka, L. (Co-Investigator)
MRC Medical Research Council, Guy's & St Thomas' Charity
1/01/2009 → 14/02/2013
Project: Research
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Defining the effects of microRNAs in the activation and lineage commitment of T-cells, and their use as biomarkers of allograft rejection
Lechler, R. (Primary Investigator), Lombardi, G. (Primary Investigator) & Lord, G. (Primary Investigator)
1/12/2008 → 30/11/2011
Project: Research
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Can we use biomarkers of tolerance to predict good outcome of immunosupression minimisation?
Hernandez Fuentes, M. (Primary Investigator), Lechler, R. (Primary Investigator), Lord, G. (Primary Investigator), Hilton, R. (Co-Investigator), Janssen, U. (Co-Investigator) & Sinha, M. (Co-Investigator)
1/11/2008 → 31/10/2011
Project: Research
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Defining the Effects of selected microRNAs in the activation and lineage commitment of T-cells, in the context of renal transplatation
Lechler, R. (Primary Investigator), Lombardi, G. (Primary Investigator) & Lord, G. (Primary Investigator)
1/11/2008 → 31/10/2011
Project: Research
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Clinical study of regulatory T cells as cell therapy to induce donor-specific transplantation tolerance
Lechler, R. (Primary Investigator) & Lombardi, G. (Primary Investigator)
1/09/2008 → 1/09/2011
Project: Research
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Manipulating regulatory T cells to promote clinical transplant tolerance
Lombardi, G. (Primary Investigator), Mullen, G. (Primary Investigator) & Lechler, R. (Co-Investigator)
1/09/2008 → 30/09/2013
Project: Research
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Understanding and exploiting natural mechanisms of immune regulation
Lechler, R. (Primary Investigator), Lombardi, G. (Primary Investigator), Minger, S. (Primary Investigator) & Sacks, S. (Primary Investigator)
1/09/2008 → 31/08/2013
Project: Research
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Institute of analytical toxicology and therapeutics
Kelly, F. (Primary Investigator), Kicman, A. (Primary Investigator) & Lechler, R. (Primary Investigator)
1/06/2008 → 31/05/2013
Project: Research
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Driving Sino-UK innovation in regenerative medicine
Salter, B. (Primary Investigator), Hylands, P. (Co-Investigator), Lechler, R. (Co-Investigator), Mann, G. (Co-Investigator) & Minger, S. (Co-Investigator)
1/01/2008 → 31/12/2010
Project: Research
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Novel therapeutic strategies to promote tolerance to pancreatic islet allograft.
Lombardi, G. (Primary Investigator), Mirenda, V. (Primary Investigator), Amiel, S. (Co-Investigator), Huang, G. (Co-Investigator), Lechler, R. (Co-Investigator) & Okkenhaug, K. (Co-Investigator)
1/01/2008 → 1/08/2012
Project: Research
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Define the mechanisms of Galectin-1 mediated CD4+CD25+ Tcell suppression
Lombardi, G. (Primary Investigator) & Lechler, R. (Co-Investigator)
1/01/2008 → 31/12/2010
Project: Research
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Defining the transcriptional mechanisms of control of T cell regulatory and effector function in renal transplantation
Lord, G. (Primary Investigator) & Lechler, R. (Co-Investigator)
NKRF National Kidney Research Fund
17/09/2007 → 16/09/2010
Project: Research
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New diagnostic and treatment approaches in organ and stem cell transplantation (MRC Centre for Transplantation)
Sacks, S. (Primary Investigator), De Bari, C. (Co-Investigator), Hayday, A. (Co-Investigator), Lechler, R. (Co-Investigator), Nestle, F. (Co-Investigator), Razavi, R. (Co-Investigator), Sharpe, P. (Co-Investigator) & Solomon, E. (Co-Investigator)
1/04/2007 → 31/12/2012
Project: Research
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Preclinical study of CD4+CD25+ regulatory T cells with indirect allospecificity as cell therapy to Induce donor-specific cardiac transplantation tolerance (Intermediate Research fellowship)
Jiang, S. (Primary Investigator) & Lechler, R. (Co-Investigator)
1/01/2006 → 31/12/2008
Project: Research
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Does cognate specificity enhance the efficacy of regulatory T cells?
Afzali, B. (Primary Investigator), Lechler, R. (Primary Investigator) & Lombardi, G. (Primary Investigator)
1/10/2005 → 16/10/2008
Project: Research
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Targeted inhibition of co-agulation - an anti-inflammatory approach to prolonging organ graft survival
Lechler, R. (Primary Investigator) & Lombardi, G. (Co-Investigator)
1/09/2005 → 31/10/2008
Project: Research
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The molecular basis of T cell immunity to metals.
Lombardi, G. (Primary Investigator) & Lechler, R. (Co-Investigator)
1/09/2005 → 31/12/2005
Project: Research
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Promoting Transplantation Tolerance: Adoptive T Cell therapy Using Customised Regulatory Cells
Lechler, R. (Primary Investigator)
ROTRF Roche Organ Transplantation Research Foundation
1/06/2005 → 31/05/2007
Project: Research
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Reprogramming the Immune System for the Establishment of Tolerance - RISET - Validating immune-tolerant signature
Hernandez Fuentes, M. (Primary Investigator), Lechler, R. (Primary Investigator), Lombardi, G. (Co-Investigator) & Lord, G. (Co-Investigator)
1/03/2005 → 31/08/2010
Project: Research
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Modulation of inflammatory responses by genetic manipulation: potential strategies for long term xenograft survival
Lechler, R. (Primary Investigator)
1/01/2005 → 30/09/2005
Project: Research
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Defining and refining T cell regulation: towards transplantation tolerance
Lechler, R. (Primary Investigator), Lombardi, G. (Co-Investigator) & academic, A. (Co-Investigator)
1/01/2005 → 30/09/2008
Project: Research
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Demonstrating the applicability of novel indices of immunological tolerance to clinical practice using immunosuppression-free transplant recipients - Indices of Tolerance
Lechler, R. (Primary Investigator)
1/01/2005 → 31/08/2006
Project: Research
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Exploiting the role of parenchymal antigen presentation to the alloresponse and autoimmunity
Buckland, M. (Primary Investigator) & Lechler, R. (Primary Investigator)
1/01/2005 → 30/06/2006
Project: Research
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Development of antigen-specific assays of donor-specific tolerance in renal transplant recipients
Lechler, R. (Primary Investigator)
NIH National Institutes of Health
1/12/2004 → 30/09/2007
Project: Research