Search results

• 2010

  A novel technique to explore the functions of bronchial mucosal T cells in chronic obstructive pulmonary disease: application to cytotoxicity and cytokine immunoreactivity

  Lethbridge, M. W., Kemeny, D. M., Ratoff, J. C., O'Connor, B. J., Hawrylowicz, C. M. & Corrigan, C. J., Sept 2010, In: Clinical and Experimental Immunology. 161, 3, p. 560 - 569 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Cytotoxic T-Cell 100%
  • CD4 CD8 Ratio 100%
  9 Citations (Scopus)
• 2005

  Intracellular cytokines may model immunoregulation of abacavir hypersensitivity in HIV-infected subjects

  King, D., Tomkins, S., Waters, A., Easterbrook, P. J., Thurmond, L. M., Thorborn, D. E., Raffi, F., Kemeny, D. M. & Vyakarnam, A., May 2005, In: Journal of Allergy and Clinical Immunology. 115, 5, p. 1081 - 1087 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Hypersensitive Response 100%
  • B Cell 25%
  • Allergy 25%
  • Cytotoxic T Cell 25%
  • Macrophage Inflammatory Protein 25%
  17 Citations (Scopus)
• 2004

  Anti-CD3 sFv/IL-18 fusion DNA for allergy therapy

  Salagianni, M. & Kemeny, D. M., Jan 2004, In: Immunology. 111, 1, p. 16 - 18 3 p.

  Research output: Contribution to journal › Editorial › peer-review
  1 Citation (Scopus)

• Pentoxifylline improves hemoglobin levels in patients with erythropoietin-resistant anemia in renal failure

  Cooper, A., Mikhail, A., Lethbridge, M. W., Kemeny, D. M. & Macdougall, I. C., Jul 2004, In: Journal of the American Society of Nephrology. 15, 7, p. 1877 - 1882 6 p.

  Research output: Contribution to journal › Article › peer-review
  80 Citations (Scopus)

• Re-challenging patients who developed pure red cell aplasia with epoetin: can it be done?

  Macdougall, L. C., Roche, A., Rossert, J., Casadevall, N., Francois, P. & Kemeny, D. M., Nov 2004, In: Nephrology, Dialysis, Transplantation. 19, 11, p. 2901 - 2905 5 p.

  Research output: Contribution to journal › Article › peer-review
  13 Citations (Scopus)

• Tc2 cells respond to soluble antigen in the respiratory tract and induce lung eosinophilia and bronchial hyperresponsiveness

  Sawicka, E., Noble, A., Walker, C. & Kemeny, D. M., Sept 2004, In: European Journal of Immunology. 34, 9, p. 2599 - 2608 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Antigen 100%
  • Cytotoxic T-Cell 42%
  • T Helper 2 Cell 42%
  • Inflammation 28%
  • Inflammation Response 28%
  28 Citations (Scopus)
• 2003

  BiP, a putative autoantigen in rheumatoid arthritis, stimulates IL-10-producing CD8-positive T cells from normal individuals

  Bodman-Smith, M. D., Corrigall, V. M., Kemeny, D. M. & Panayi, G. S., 1 May 2003, In: Rheumatology. 42, 5, p. 637 - 644 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Inflammatory Arthritis 100%
  • Inflammation 16%
  • T Cell Receptor 16%
  • Cytotoxic T-Cell 8%
  • Antigen 8%
  49 Citations (Scopus)

• Increased expression of erythropoiesis inhibiting cytokines (IFN-gamma, TNF-alpha, IL-10, and IL-13) by T cells in patients exhibiting a poor response to erythropoietin therapy

  Cooper, A. C., Mikhail, A., Lethbridge, M. W., Kemeny, D. M. & MacDougall, I. C., 1 Jul 2003, In: Journal of the American Society of Nephrology. 14, 7, p. 1776 - 1784 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Erythropoiesis 100%
  112 Citations (Scopus)

• Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720

  Sawicka, E., Zuany-Amorim, C., Manlius, C., Trifilieff, A., Brinkmann, V., Kemeny, D. M. & Walker, C., 1 Dec 2003, In: Journal of Immunology. 171, 11, p. 6206 - 6214 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory Tract Inflammation 100%
  • Sphingosine 1 Phosphate Receptor 100%
  • Inflammation 100%
  • Receptor Agonist 100%
  • Th2 Cell 71%
  128 Citations (Scopus)

• M-CSF promotes aberrant differentiation and paraptosis-like death of monocyte-derived dendritic cells by a caspase 9-dependent pathway

  Lo, A. S. Y., Kemeny, D. M. & Maher, J., 2003, In: Blood. 102, 11, p. 1904 1 p.

  Research output: Contribution to journal › Meeting abstract

• Pentoxifylline decreases T cell expression of TNF-alpha and IFN-gamma. and improves the response to erythropoietic therapy in epo-resistant CRF patients.

  Cooper, A. C., Mikhail, A., Kemeny, D. M. & Macdougall, I. C., 2003, In: Journal of the American Society of Nephrology. 14, p. 378A - 378A

  Research output: Contribution to journal › Meeting abstract

• Poor response to recombinant erythropoietin is associated with loss of T-lymphocyte CD28 expression and altered interleukin-10 production

  Cooper, A. C., Breen, C. P., Vyas, B., Ochola, J., Kemeny, D. M. & Macdougall, I. C., 1 Jan 2003, In: Nephrology, Dialysis, Transplantation. 18, 1, p. 133 - 140 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Epoetin Beta 100%
  • Inflammation 16%
  • Protein 16%
  20 Citations (Scopus)

• The role of CD8 T-cells in allergic lung inflammation

  Bienenstock, J. (Editor), Ring, J. (Editor), Togias, A. G. (Editor) & Kemeny, D. M., 2003, Unknown. TORONTO: HOGREFE & HUBER PUBLISHERS, p. 79 - 81 3 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference paper

  • Cytotoxic T-Cell 100%
  • Pulmonary Inflammation 100%
  • Lung 40%
  • Animal 25%
  • Murine 25%
• 2002

  Activation-induced cell death in human T cells is a suicidal process regulated by cell density but superantigen induces T cell fratricide

  Gorak-Stolinska, P., Kemeny, D. M. & Noble, A., Oct 2002, In: Cellular Immunology. 219, 2, p. 98 - 107 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Superantigen 100%
  • Cell Death 100%
  • Effector Cell 33%
  • T Cell Receptor 16%
  • T Cell Subset 16%
  14 Citations (Scopus)

• CD8 T cell-dendritic cell (DC) interaction in the regulation of IgE

  Ring, J. & Behrendt, H. (Editor), 2002, Unknown. BERLIN: Springer, p. 56 - 61 6 p.

  Research output: Chapter in Book/Report/Conference proceeding › Conference paper

  70 Citations (Scopus)

• CD8 T cells inhibit IgE via dendritic cell IL-12 induction that promotes Th1 T cell counter-regulation

  Thomas, M. J., Noble, A., Sawicka, E., Askenase, P. W. & Kemeny, D. M., 1 Jan 2002, In: Journal of Immunology. 168, 1, p. 216 - 223 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Immunoglobulin E 100%
  • Cytotoxic T-Cell 100%
  • Dendritic Cell 100%
  • T Cell Receptor 18%
  • T-Helper Cell 18%
  76 Citations (Scopus)

• Do functional subsets of leukocytes arise by divergent or linear differentiation?

  Noble, A. & Kemeny, D. M., 2002, In: Immunology. 106, 4, p. 443 - 446 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Natural Killer Cell 100%
  • Lineages 100%
  • Dendritic Cell 50%
  3 Citations (Scopus)

• Increased production of TNFalpha by monocytes at a single cell level in epoetin-resistant dialysis patients.

  Mikhail, A. I., Cooper, A. C., Kemeny, D. M. & Macdougall, I. C., 2002, In: Journal of the American Society of Nephrology. 13, p. 583A - 583A

  Research output: Contribution to journal › Meeting abstract

• Pentoxifylline therapy improves erythropoiesis in CRF patients with a poor response to erythropoietin.

  Mikhail, A. I., Cooper, A. C., Kemeny, D. M. & Macdougall, I. C., 2002, In: Journal of the American Society of Nephrology. 13, p. 580A - 581A

  Research output: Contribution to journal › Meeting abstract

• Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells

  Zuany-Amorim, C., Sawicka, E., Manlius, C., Le Moine, A. L., Brunet, L. R., Kemeny, D. M., Bowen, G., Rook, G. & Walker, C., 2002, In: Nature Medicine. 8, 6, p. 625 - 629 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Allergy 100%
  • T Helper 2 Cell 100%
  • Inflammation 49%
  • Inflammatory Disorder 49%
  462 Citations (Scopus)

• The changes in airway inflammatory cells following inhalation of lipopolysaccharide (LPS)

  Allenby, M. I., Lethridge, M. W., Ketchell, R. I., Woisin, F. E., Jensen, M. W., Kemeny, D. M. & O'Connor, B. J., 2002, In: Journal of Allergy and Clinical Immunology. 109, 1, p. S30 - S31

  Research output: Contribution to journal › Meeting abstract
• 2001

  Activation-induced cell death of human T-cell subsets is mediated by Fas and granzyme B but is independent of TNF-alpha

  Gorak-Stolinska, P., Truman, J. P., Kemeny, D. M. & Noble, A., 2001, In: Journal of Leukocyte Biology. 70, 5, p. 756 - 766 11 p.

  Research output: Contribution to journal › Article › peer-review

  • T Cell Subset 100%
  • Cell Death 100%
  • Tumor Necrosis Factor 12%
  44 Citations (Scopus)

• Allergen-specific Th1 cells counteract efferent Th2 cell-dependent bronchial hyperresponsiveness and eosinophilic inflammation partly via IFN-gamma

  Huang, T. J., MacAry, P. A., Eynott, P., Moussavi, A., Daniel, K. C., Askenase, P. W., Kemeny, D. M. & Chung, K. F., 2001, In: Journal of Immunology. 166, 1, p. 207 - 217 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Inflammation 100%
  • Lung 11%
  123 Citations (Scopus)

• Changes in mucosal inflammatory cells following inhalation of lipopolysaccharide (LPS)

  Allenby, M. I., Lethbridge, M. W., Sousa, A. R., Ketchell, R. I., Woisin, F. W., Jensen, M., Kemeny, D. M. & O'Connor, B. J., 2001, In: Thorax. 56, p. 12 - 12 1 p.

  Research output: Contribution to journal › Meeting abstract

• Early Th1/Th2 cell polarization in the absence of IL-4 and IL-12: T cell receptor signaling regulates the response to cytokines in CD4 and CD8 T cells

  Noble, A., Thomas, M. J. & Kemeny, D. M., 2001, In: European Journal of Immunology. 31, 7, p. 2227 - 2235 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Cytotoxic T-Cell 100%
  • T Cell Receptor 100%
  • T-Helper Cell 100%
  • T Cell Activation 12%
  44 Citations (Scopus)

• Specificity, restriction and effector mechanisms of immunoregulatory CD8 T cells

  Vukmanovic-Stejic, M., Thomas, M. J., Noble, A. & Kemeny, D. M., 2001, In: Immunology. 102, 2, p. 115 - 122 8 p.

  Research output: Contribution to journal › Literature review › peer-review

  28 Citations (Scopus)

• T cytotoxic 1 and T cytotoxic 2 CD8 T cells both inhibit IgE responses

  Thomas, M. J., MacAry, P. A., Noble, A., Askenase, P. W. & Kemeny, D. M., 2001, In: International Archives of Allergy and Immunology. 124, 1-3, p. 187 - 189 3 p.

  Research output: Contribution to journal › Conference paper

  • Immunoglobulin E 100%
  • Cytotoxic T-Cell 100%
  • T Cell Receptor 20%
  18 Citations (Scopus)

• The use of intracellular single-chain antibody fragments to specifically inhibit cytokine secretion

  Daniel, K. C., Gaken, J. A., Farzaneh, F. & Kemeny, D. M., 2001, In: International Archives of Allergy and Immunology. 124, 1-3, p. 216 - 217 2 p.

  Research output: Contribution to journal › Conference paper

  • Protein 100%
  • Gene 100%
  1 Citation (Scopus)
• 2000

  Antigen-specific and nonspecific determinants of cytokine production during topical sensitization of mice to chemical allergens

  Moussavi, A., Dearman, R. J., Kimber, I., Daniel, K. C. & Kemeny, D. M., 2000, In: Journal of Allergy and Clinical Immunology. 106, 2, p. 357 - 368 12 p.

  Research output: Contribution to journal › Article › peer-review

  • T-Helper Cell 100%
  • Dendritic Cell 100%
  • Antigen 33%
  • Mitogen 16%
  • T Cell Proliferation 16%

• DNase I footprinting of the human interleukin-5 gene promoter

  Cousins, D. J., Richards, D., Kemeny, D. M., Romagnani, S., Lee, T. H. & Staynov, D. Z., Jan 2000, In: Immunology. 99, 1, p. 101-108 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Eosinophil Granulocyte 100%
  • T Helper Cell 100%
  • Lymphokine 100%
  5 Citations (Scopus)

• Effect of cytokines on IgE switching by human B cells

  Bitsaktsis, C., Wheeler, D. & Kemeny, D. M., 2000, In: Immunology. 101, p. 79 1 p.

  Research output: Contribution to journal › Article › peer-review

• Harnessing the tumor-derived cytokine, macrophage colony-stimulating factor (M-CSF), to costimulate genetically modified T cells.

  Maher, J., Lo, A. S. Y., Dibb, N. J., Farzaneh, F., Sadelain, M. & Kemeny, D. M., 2000, In: Blood. 96, 11, p. 294A - 294A

  Research output: Contribution to journal › Meeting abstract

• Human Tc1 and Tc2/Tc0 CD8 T-cell clones display distinct cell surface and functional phenotypes

  Vukmanovic-Stejic, M., Vyas, B., Gorak-Stolinska, P., Noble, A. & Kemeny, D. M., 1 Jan 2000, In: Blood. 95, 1, p. 231 - 240 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Cytotoxic T-Cell 100%
  • T Cell Subset 28%
  • Cell Death 14%
  134 Citations (Scopus)

• Modulation of PKC, Ca2+ and MAPK signalling pathways alters the generation of type-1 and type-2 cytokines

  Vyas, B., Vukmanovic-Stejic, M., Noble, A. & Kemeny, D. M., 2000, In: Immunology. 101, p. 106 1 p.

  Research output: Contribution to journal › Article › peer-review

• Nonatopic wheezy children have reduced interferon-gamma

  Leech, S. C., Price, J. F., Holmes, B. J. & Kemeny, D. M., 2000, In: Allergy. 55, 1, p. 74 - 78 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Supernatant 100%
  13 Citations (Scopus)

• The balance of protein kinase C and calcium signaling directs T cell subset development

  Noble, A., Truman, J. P., Vyas, B., Vukmanovic-Stejic, M., Hirst, W. J. & Kemeny, D. M., 15 Feb 2000, In: Journal of Immunology. 164, 4, p. 1807 - 1813 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Calcium Signaling 100%
  • T Cell Subset 100%
  • T Cell Receptor 50%
  • T Cell 40%
  • Stimulation 40%
  55 Citations (Scopus)

• The effect of 15mug LPS inhalation challenge on peripheral T lymphocytes of 10 healthy non-smokers

  Lethbridge, M., Vyas, B., Loh, R., O'Connor, B. J. & Kemeny, D. M., 2000, In: Immunology. 101, p. 94 1 p.

  Research output: Contribution to journal › Article › peer-review

• The effects of pollutants on the allergic immune response

  Kemeny, D. M., 2 Nov 2000, In: Toxicology. 152, 1-3, p. 3 - 12 10 p.

  Research output: Contribution to journal › Conference paper

  • Cytotoxic T-Cell 100%
  • Allergy 100%
  • Immunoglobulin E 50%
  9 Citations (Scopus)

• The role of CD23 on allergen-induced IgE levels, pulmonary eosinophilia and bronchial hyperresponsiveness in mice

  Riffo Vasquez, Y., Spina, D., Thomas, M., Gilbey, T., Kemeny, D. M. & Page, C. P., 2000, In: Clinical and Experimental Allergy. 30, 5, p. 728 - 738 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Immunoglobulin E 100%
  • CD23 100%
  • Antigen 23%
  • Eosinophil Granulocyte 17%
  • Inflammation 11%
  34 Citations (Scopus)
• 1997

  Immune memory in CD4+ CD45RA+ T cells

  Richards, D., Chapman, M. D., Sasama, J., Lee, T. H., Kemeny, D. M. & Richards, D., Jul 1997, In: Immunology. 91, 3, p. 331-9 9 p.

  Research output: Contribution to journal › Article › peer-review

  30 Citations (Scopus)