Research output per year
Research output per year
- 1 - 50 out of 112 results
Search results
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2023
Heritable diversity in the human antigen inexperienced B cell repertoire
Pitcher, M. J. & Spencer, J., Aug 2023, In: Molecular Immunology. 160, p. 20-22 3 p.Research output: Contribution to journal › Letter › peer-review
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Weller et al., T-independent responses to polysaccharides in humans mobilize marginal zone B cells pre-diversified against gut bacterial antigens[1]
Spencer, J., Tull, T. J. & Bemark, M., 1 Apr 2023, In: Immunology Letters. 256-257, p. 66-67 2 p.Research output: Contribution to journal › Letter › peer-review
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2022
A SIMPLI (Single-cell Identification from MultiPLexed Images) approach for spatially-resolved tissue phenotyping at single-cell resolution
Bortolomeazzi, M., Montorsi, L., Temelkovski, D., Keddar, M. R., Acha-Sagredo, A., Pitcher, M. J., Basso, G., Laghi, L., Rodriguez-Justo, M., Spencer, J. & Ciccarelli, F. D., 9 Feb 2022, In: Nature Communications. 13, 1, 1 p., 781.Research output: Contribution to journal › Article › peer-review
Open Access20 Citations (Scopus) -
B cells in human lymphoid structures
Montorsi, L., Siu, J. & Spencer, J., 19 Sept 2022, (Accepted/In press) In: Clinical and Experimental Immunology.Research output: Contribution to journal › Review article › peer-review
File58 Downloads (Pure) -
ChAdOx1 nCoV-19 vaccine elicits monoclonal antibodies with cross-neutralizing activity against SARS-CoV-2 viral variants
Seow, J., Graham, C., Hallett, S., Lechmere, T., Maguire, T., Huettner, I., Cox, D., Khan, H., Pickering, S., Waters, A., Ward, C., Mant, C., Pitcher, M., Spencer, J., Fox, J., Malim, M. & Doores, K., 3 May 2022, In: Cell Reports. 39, 5, 110757.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
Defective STAT5 Activation and Aberrant Expression of BCL6 in Naive CD4 T Cells Enhances Follicular Th Cell-like Differentiation in Patients with Granulomatosis with Polyangiitis
Kim, S., Boehme, L., Nel, L., Casian, A., Sangle, S., Nova-Lamperti, E., Seitan, V., Spencer, J., Lavender, P., D'Cruz, D. P. & John, S., 15 Feb 2022, In: Journal of immunology (Baltimore, Md. : 1950). 208, 4, p. 807-818 12 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Disrupted Peyer’s patch microanatomy in COVID-19 including germinal centre atrophy independent of local virus
Cellone Trevelin, S., Pickering, S., Todd, K., Bishop, C., Pitcher, M., Garrido Mesa, J., Montorsi, L., Spada, F., Petrov, N., Green, A., Shankar-Hari, M., Neil, S. & Spencer, J., 27 Jan 2022, (Accepted/In press) In: Frontiers in Immunity- sub specialisation, Mucosal Immunity.Research output: Contribution to journal › Article › peer-review
Open AccessFile66 Downloads (Pure) -
Human B cells
Spencer, J., Bemark, M. & Tull, T. J., Dec 2022, In: Clinical and Experimental Immunology. 210, 3, p. 199-200 2 p.Research output: Contribution to journal › Editorial › peer-review
Open Access1 Citation (Scopus) -
The phenotype of HLA-binding B-cells from sensitised renal transplant recipients correlates with clinically prognostic patterns of IFNγ production against purified HLA proteins
Burton, H., McLaughlin, L., Shiu, K. Y., Shaw, O., Mamode, N., Spencer, J. & Dorling, A., 21 Jul 2022, In: Kidney International. 102, 2, p. 355-369Research output: Contribution to journal › Article › peer-review
Open AccessFile51 Downloads (Pure) -
The phenotype of HLA-binding B cells from sensitized kidney transplant recipients correlates with clinically prognostic patterns of interferon-γ production against purified HLA proteins
Burton, H., McLaughlin, L., Shiu, K. Y., Shaw, O., Mamode, N., Spencer, J. & Dorling, A., Aug 2022, In: Kidney International. 102, 2, p. 355-369 15 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood
Spencer, J., Siu, J., Pitcher, M., Tull, T., Velounias, R., Guesdon, W., Montorsi, L., Mahbubani, K., Ellis, R., kadolsky, U., Kleeman, M., D'Cruz, D., Saeb-Parsy, K., Bemark, M. & Pettigrew, G., 18 Mar 2022, In: Science Immunology. 7, 69, p. eabm9060Research output: Contribution to journal › Article › peer-review
Open AccessFile38 Citations (Scopus)525 Downloads (Pure) -
Two subsets of human marginal zone B cells resolved by global analysis of lymphoid tissues and blood
Siu, J. H. Y., Pitcher, M. J., Tull, T. J., Velounias, R. L., Guesdon, W., Montorsi, L., Mahbubani, K. T., Ellis, R., Dhami, P., Todd, K., Kadolsky, U. D., Kleeman, M., D'Cruz, D. P., Saeb-Parsy, K., Bemark, M., Pettigrew, G. J. & Spencer, J., 18 Mar 2022, In: Science Immunology. 7, 69, p. eabm9060Research output: Contribution to journal › Article › peer-review
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2021
Human gut-associated lymphoid tissues (GALT); diversity, structure, and function
Mörbe, U. M., Jørgensen, P. B., Fenton, T. M., von Burg, N., Riis, L. B., Spencer, J. & Agace, W. W., Jul 2021, In: Mucosal Immunology. 14, 4, p. 793-802 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access213 Citations (Scopus) -
Human marginal zone B cell development from early T2 progenitors
Spencer, J., Tull, T., Pitcher, M., Guesdon, W., Siu, J. H., Lebraro-Fernandez, C., Zhao, Y., Petrov, N., Heck, S., Ellis, R., Dhami, P., kadolsky, U., Kleeman, M., Kamra, Y., Fear, D., John, S., Jassem, W., Groves, R., Sanderson, J. D. & Robson, M. & 2 others, , 5 Apr 2021, In: Journal of Experimental Medicine. 218, 4, e20202001.Research output: Contribution to journal › Article › peer-review
Open AccessFile49 Citations (Scopus)238 Downloads (Pure) -
Immunogenomics of colorectal cancer response to checkpoint blockade: analysis of the KEYNOTE 177 trial and validation cohorts
Bortolomeazzi, M., Keddar, M. R., Montorsi, L., Acha-sagredo, A., Benedetti, L., Temelkovski, D., Choi, S., Petrov, N., Todd, K., Wai, P., Kohl, J., Denner, T., Nye, E., Goldstone, R., Ward, S., Wilson, G. A., Al Bakir, M., Swanton, C., John, S. & Miles, J. & 9 others, , Oct 2021, In: Gastroenterology. 161, 4, p. 1179-1193 15 p.Research output: Contribution to journal › Article › peer-review
Open Access75 Citations (Scopus) -
Quantitative assessment of NFκB transcription factor activity
Hunter, T. T. J., Fear, D., Lavender, P., Spencer, J., Peakman, M. & Ibrahim, M. A. A., May 2021, In: Journal of Immunological Methods. 492, 112954.Research output: Contribution to journal › Article › peer-review
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2019
Reduced CD27-IgD- B cells in blood and raised CD27-IgD- B cells in gut-associated lymphoid tissue in inflammatory bowel disease.
Pararasa, C., Zhang, N., Tull, T. J., Chong, M. H., Siu, J. H., Guesdon, W. W. J., Chavele, K.-M., Sanderson, J., Langmead, L., Kok, K., Spencer, J. M. & vossenkamper, A., 5 Mar 2019, In: Frontiers in Immunology. 10, 361.Research output: Contribution to journal › Article › peer-review
Open AccessFile31 Citations (Scopus)198 Downloads (Pure) -
Sneddon Syndrome associated with two novel ADA2 gene mutations
Tull, T. J., Martin, B., Spencer, J. M., Sangle, S., Chua, S., McGrath, J. A., D'Cruz, D. & McGibbon, D. H., 29 Oct 2019, (Accepted/In press) In: Rheumatology.Research output: Contribution to journal › Article › peer-review
Open AccessFile71 Downloads (Pure) -
Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells
Jimeno , R., Lebrusant-Fernandez, M., Margreitter, C., Lucas, B., Veerapen, N., Besra, G., Fraternali, F., Spencer, J., Anderson, G. & Barral, P., 24 Dec 2019, In: eLife. 8, e51663.Research output: Contribution to journal › Article › peer-review
Open AccessFile17 Citations (Scopus)235 Downloads (Pure) -
2018
Human intestinal lymphoid tissue in time and space
Spencer, J. M., Siu, J. H. & Montorsi, L., Dec 2018, In: Mucosal Immunology. 12, 12, p. 296 298 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)158 Downloads (Pure) -
Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis - pilot study
Wilson, J. K., Zhao, Y., Singer, M., Spencer, J. & Shankar-Hari, M., 17 Apr 2018, In: CRITICAL CARE.Research output: Contribution to journal › Article › peer-review
Open AccessFile61 Citations (Scopus)338 Downloads (Pure) -
Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients
Chatterjee, G., Pai, T., Avery-Kiejda, K., Scott, R., Spencer, J. M., Pinder, S. E. & Grigoriadis, A., 24 Oct 2018, (Accepted/In press) In: Breast Cancer Research. 20, 1, p. 143Research output: Contribution to journal › Article › peer-review
Open AccessFile18 Citations (Scopus)218 Downloads (Pure) -
Spatiotemporal segregation of human marginal zone and memory B cell populations in lymphoid tissue
Zhao, Y., Uduman, M., Siu, J., Tull, T. J., Sanderson, J., Wu, Y.-C. B., Zhou, J. Q., Petrov, N., Ellis, R. J., Todd, S. K., Chavele, K.-M., Guesdon, W. W. J., Vossenkamper, A., Jassem, W., D’Cruz, D., Fear, D. J., John, S., Scheel-Toellner, D., hopkins, C. & Moreno, E. & 6 others, , 21 Sept 2018, In: Nature Communications. 9, 1, 15 p., 3857.Research output: Contribution to journal › Article › peer-review
Open AccessFile78 Citations (Scopus)352 Downloads (Pure) -
2017
Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis
Shankar-Hari, M., Fear, D., Lavender, P., Mare, T., Beale, R., Swanson, C., Singer, M. & Spencer, J., May 2017, In: Critical Care Medicine. 45, 5, p. 875-882 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile82 Citations (Scopus)473 Downloads (Pure) -
Can concurrent abnormalities in free light chains and immunoglobulin concentrations identify a target population for immunoglobulin trials in sepsis?
Shankar-Hari, M., Singer, M. & Spencer, J., 30 Nov 2017, In: Critical Care Medicine. 45, 11, p. 1829-1836Research output: Contribution to journal › Article › peer-review
Open AccessFile19 Citations (Scopus)277 Downloads (Pure) -
Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma
Brencicova, E., Jagger, A. L., Evans, H. G., Georgouli, M., Laios, A., Montalto, S. A., Mehra, G., Spencer, J., Ahmed, A. A., Raju-Kankipati, S., Taams, L. S. & Diebold, S. S., 1 Apr 2017, In: PL o S One . 12, 4, 24 p., e0175712.Research output: Contribution to journal › Article › peer-review
Open AccessFile36 Citations (Scopus)159 Downloads (Pure) -
2016
Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes
Cereda, M., Gambardella, G., Benedetti, L. G., Iannelli, F., Patel, D., Basso, G., Guerra, R., Mourikis, T. P., Puccio, I., Sinha, S., Laghi, L., Spencer, J., Rodriguez-Justo, M. & Ciccarelli, F. D., 5 Jul 2016, In: Nature Communications. 7, 1, 12 p., 12072.Research output: Contribution to journal › Article › peer-review
Open AccessFile42 Citations (Scopus)279 Downloads (Pure) -
The human intestinal B-cell response
Spencer, J. & Sollid, L. M., 1 Sept 2016, In: Mucosal Immunology. 9, 5, p. 1113-1124 12 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile79 Citations (Scopus)242 Downloads (Pure) -
2015
Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model
Alhabbab, R., Blair, P., Elgueta, R., Stolarczyk, E., Marks, E., Becker, P. D., Ratnasothy, K., Smyth, L., Safinia, N., Sharif-Paghaleh, E., O'Connell, S., Noelle, R. J., Lord, G. M., Howard, J. K., Spencer, J., Lechler, R. I. & Lombardi, G., 25 Jun 2015, In: Scientific Reports. 5, 11554.Research output: Contribution to journal › Article › peer-review
Open AccessFile32 Citations (Scopus)190 Downloads (Pure) -
Endogenous IgG hypogammaglobulinaemia in critically ill adults with sepsis: systematic review and meta-analysis
Shankar-Hari, M., Culshaw, N., Post, B., Tamayo, E., Andaluz-Ojeda, D., Bermejo-Martín, J. F., Dietz, S., Werdan, K., Beale, R., Spencer, J. & Singer, M., 14 May 2015, In: Intensive Care Medicine. 41, 8, p. 1393-1401 9 p.Research output: Contribution to journal › Article › peer-review
60 Citations (Scopus) -
Immunoglobulin kappa variable region gene selection during early B cell development in health and systemic lupus erytyhematosus
Hehle, V., Fraser, L., Tahir, R., Kipling, D., Wu, Y.-C., Lutalo, P., Cason, J., Choong, L., D’Cruz, D. P., Cope, A. P., Dunn-Walters, D. & Spencer, J., Jun 2015, In: Molecular Immunology. 65, 2, p. 215-223 9 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
Immunoglobulin light chain allelic inclusion in systemic lupus erythematosus
Fraser, L. D., Zhao, Y., Lutalo, P. M. K., D’Cruz, D., Cason, J., Silva O'Hare, J., Dunn-Walters, D., Nayar, S., Cope, A. P. & Spencer, J., Aug 2015, In: European Journal of Immunology. 45, 8, p. 2409-2419 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile14 Citations (Scopus)183 Downloads (Pure) -
Mucosal B Cell Differentiation and Regulation
Lycke, N., Bemark, M. & Spencer, J., 1 Apr 2015, Mucosal Immunology: Fourth Edition. ELSEVIER SCIENCE INC, Vol. 1-2. p. 701-719 19 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
2 Citations (Scopus) -
2014
B CELLS WITH BOTH SURFACE KAPPA AND LAMBDA LIGHT CHAINS ARE PRESENT IN THE CIRCULATION IN ICU PATIENTS WITH SEPSIS AND THEIR FREQUENCY CORRELATES WITH FREE LIGHT CHAIN CONCENTRATIONS IN SERUM
Shankar-Hari, M., Tahir, R., Assi, L., Beale, R., Singer, M. & Spencer, J., 25 Sept 2014, In: Intensive Care Medicine. 40, 1, p. S89-S89 1 p., 0299.Research output: Contribution to journal › Conference paper › peer-review
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Circulating T follicular helper cell and regulatory T cell frequencies are influenced by B cell depletion in patients with granulomatosis with polyangiitis
Zhao, Y., Lutalo, P. M. K., Thomas, J. E., Sangle, S., Choong, L. M., Tyler, J. R., Tree, T., Spencer, J. & D’Cruz, D., Apr 2014, In: Rheumatology. 53, 4, p. 621-630 10 p.Research output: Contribution to journal › Article › peer-review
49 Citations (Scopus) -
FREE IMMUNOGLOBULIN LIGHT CHAIN CONCENTRATIONS, RATIOS ANT) OUTCOMES IN CRITICALLY ILL ADULTS WITH SEPSIS: A COHORT STUDY
Shankar-Hari, M., Assi, L., Beale, R., Spencer, J. & Singer, M., Sept 2014, In: Intensive Care Medicine. 40, p. S87-S88 2 p.Research output: Contribution to journal › Meeting abstract › peer-review
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IMMUNOGTOBUTLN G CONCENTRATIONS AND OUTCOMES CRITICALLY ILL ADULTS WITH SEPSIS: A SYSTEMATIC REVIEW ES IN CRITICALLY
Culshaw, N., Post, B., Beale, R., Spencer, J., Singer, M. & Shankar-Hari, M., Sept 2014, In: Intensive Care Medicine. 40, p. S151-S151 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
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2013
A role for gut-associated lymphoid tissue in shaping the human B cell repertoire
Vossenkämper, A., Blair, P. A., Safinia, N., Fraser, L. D., Das, L., Sanders, T. J., Stagg, A. J., Sanderson, J. D., Taylor, K., Chang, F., Choong, L. M., D’Cruz, D., Macdonald, T. T., Lombardi, G. & Spencer, J., 12 Aug 2013, In: Journal of Experimental Medicine. 210, 9, p. 1665-1674 10 p.Research output: Contribution to journal › Article › peer-review
83 Citations (Scopus) -
Clinical evidence for allergy in orofacial granulomatosis and inflammatory bowel disease
Patel, P., Brostoff, J., Campbell, H., Goel, R. M., Taylor, K., Ray, S., Lomer, M. C. E., Escudier, M., Challacombe, S., Spencer, J. & Sanderson, J., 15 Aug 2013, In: Clinical and translational allergy. 3, 1, 26.Research output: Contribution to journal › Article › peer-review
Open Access35 Citations (Scopus) -
Defective CD8(+)CD28(-) regulatory T cell suppressor function in rheumatoid arthritis is restored by tumour necrosis factor inhibitor therapy
Ceeraz, S., Hall, C., Choy, E. H., Spencer, J. & Corrigall, V. M., Oct 2013, In: Clinical and Experimental Immunology. 174, 1, p. 18-26 9 p., N/A.Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus) -
2012
Bench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective
Shankar-Hari, M., Spencer, J., Sewell, W. A., Rowan, K. M. & Singer, M., 16 Mar 2012, In: CRITICAL CARE. 16, 2, 206.Research output: Contribution to journal › Article › peer-review
98 Citations (Scopus) -
Granulomatosis with polyangiitis involves sustained mucosal inflammation that is rich in B-cell survival factors and autoantigen
Zhao, Y., Odell, E., Choong, L. M., Barone, F., Fields, P., Wilkins, B., Tungekar, F. M., Patel, P., Sanderson, J. D., Sangle, S., D’Cruz, D. & Spencer, J., Sept 2012, In: Rheumatology. 51, 9, p. 1580-1586 7 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Citations (Scopus) -
LOW IMMUNOGLOBULIN I; LEVELS AT ADMISSION REDUCES THE ODDS FOR 28 DAY MORTALITY COMPARED TO NORMAL LEVELS: PROSPECTIVE COHORT STUDY IN SEVERE SEPSIS
Shankar-Hari, M., Singer, M., Cornelius, V., Sanderson, B., Gordon, A., Terblanche, M., Rowan, K., Beale, R. & Spencer, J., Oct 2012, In: Intensive Care Medicine. 38, p. S54-S54 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
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The human intestinal IgA response; burning questions
Spencer, J., Klavinskis, L. S. & Fraser, L. D., 11 May 2012, In: Frontiers in Immunology. 3, 108.Research output: Contribution to journal › Article › peer-review
27 Citations (Scopus) -
Translational Mini-Review Series on B cell subsets in disease. Transitional B cells in systemic lupus erythematosus and Sjogren's syndrome: clinical implications and effects of B cell-targeted therapies
Vossenkaemper, A., Lutalo, P. M. K. & Spencer, J., Jan 2012, In: Clinical and Experimental Immunology. 167, 1, p. 7 - 14 8 p.Research output: Contribution to journal › Literature review › peer-review
42 Citations (Scopus) -
2011
IgA-Producing Plasma Cells Originate From Germinal Centers That Are Induced by B-Cell Receptor Engagement in Humans
Barone, F., Vossenkamper, A., Boursier, L., Su, W., Watson, A., John, S., Dunn-Walters, D. K., Fields, P., Wijetilleka, S., Edgeworth, J. D. & Spencer, J., Mar 2011, In: Gastroenterology. 140, 3, p. 947 - 956 10 p.Research output: Contribution to journal › Article › peer-review
63 Citations (Scopus) -
Mouse and human intestinal immunity: same ballpark, different players; different rules, same score
Gibbons, D. L. & Spencer, J., Mar 2011, In: Mucosal Immunology. 4, 2, p. 148 - 157 10 p.Research output: Contribution to journal › Literature review › peer-review
134 Citations (Scopus) -
Pivotal Advance: CD45RB glycosylation is specifically regulated during human peripheral B cell differentiation
Koethe, S., Zander, L., Koster, S., Annan, A., Ebenfelt, A., Spencer, J. & Bemark, M., Jul 2011, In: Journal of Leukocyte Biology. 90, 1, p. 5 - 19 15 p.Research output: Contribution to journal › Article › peer-review
31 Citations (Scopus) -
Transitional B Cells: How Well Are the Checkpoints for Specificity Understood?
Vossenkämper, A. & Spencer, J., Oct 2011, In: Archivum Immunologiae et Therapiae Experimentalis. 59, 5, p. 379 - 384 6 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
2010
DEFECTIVE CD3+CD8+CD28 SUPPRESSOR FUNCTION IN RA PATIENTS IS PARTIALLY RESTORED AFTER ANTI-TNF alpha INHIBITOR THERAPY AND MAY BE ASSOCIATED WITH REDUCED ICOS AND PD-1 EXPRESSION
Ceeraz, S., Spencer, J., Choy, E. H. & Corrigall, V., 2010, In: Rheumatology. 49, p. I26 - I26Research output: Contribution to journal › Meeting abstract