@article{862dd8ef8a1c4780ae3023f3e56425b8,
title = "Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls",
abstract = "Background: The risk factors for recovery from COVID-19 dyspnoea are poorly understood. We investigated determinants of recovery from dyspnoea in adults with COVID-19 and compared these to determinants of recovery from non-COVID-19 dyspnoea. Methods: We used data from two prospective cohort studies: PHOSP-COVID (patients hospitalised between March 2020 and April 2021 with COVID-19) and COVIDENCE UK (community cohort studied over the same time period). PHOSP-COVID data were collected during hospitalisation and at 5-month and 1-year follow-up visits. COVIDENCE UK data were obtained through baseline and monthly online questionnaires. Dyspnoea was measured in both cohorts with the Medical Research Council Dyspnoea Scale. We used multivariable logistic regression to identify determinants associated with a reduction in dyspnoea between 5-month and 1-year follow-up. Findings: We included 990 PHOSP-COVID and 3309 COVIDENCE UK participants. We observed higher odds of improvement between 5-month and 1-year follow-up among PHOSP-COVID participants who were younger (odds ratio 1.02 per year, 95% CI 1.01–1.03), male (1.54, 1.16–2.04), neither obese nor severely obese (1.82, 1.06–3.13 and 4.19, 2.14–8.19, respectively), had no pre-existing anxiety or depression (1.56, 1.09–2.22) or cardiovascular disease (1.33, 1.00–1.79), and shorter hospital admission (1.01 per day, 1.00–1.02). Similar associations were found in those recovering from non-COVID-19 dyspnoea, excluding age (and length of hospital admission). Interpretation: Factors associated with dyspnoea recovery at 1-year post-discharge among patients hospitalised with COVID-19 were similar to those among community controls without COVID-19. Funding: PHOSP-COVID is supported by a grant from the MRC-UK Research and Innovation and the Department of Health and Social Care through the National Institute for Health Research (NIHR) rapid response panel to tackle COVID-19. The views expressed in the publication are those of the author(s) and not necessarily those of the National Health Service (NHS), the NIHR or the Department of Health and Social Care. COVIDENCE UK is supported by the UK Research and Innovation, the National Institute for Health Research, and Barts Charity. The views expressed are those of the authors and not necessarily those of the funders.",
keywords = "Cohort, COVID-19, Dyspnoea, Long COVID, Recovery",
author = "{PHOSP-COVID Study Collaborative Group} and Pfeffer, {Paul E.} and K. Abel and S. Ahmad and R. Ahmed and M. Ali and Allen, {R. J.} and P. Almeida and D. Anderson and L. Armstrong and N. Armstrong and M. Ashworth and A. Ayoub and R. Baggott and L. Bailey and D. Baldwin and C. Ballard and A. Banerjee and A. Bates and M. Begum and D. Bell and R. Bell and C. Berry and K. Bhui and K. Bramham and G. Breen and C. Brookes and M. Broome and A. Brown and J. Brown and J. Brown and M. Brown and A. Burns and A. Butt and S. Byrne and G. Carson and P. Carter and T. Chalder and Chambers, {R. C.} and F. Chan and J. Chen and Y. Cheng and A. Chiribiri and N. Choudhury and P. Chowienczyk and D. Clark and C. Clark and J. Clarke and J. Cole and C. Coleman and B. Connolly and L. Connor and A. Cook and B. Cooper and J. Cooper and S. Cooper and T. Craig and A. Cross and A. David and E. Davies and Davies, {G. A.} and Davies, {G. A.} and K. Davies and Davies, {M. J.} and J. Dawson and A. Donaldson and T. Dong and A. Dougherty and R. Dowling and drury, {H. J.C.} and S. Dunn and S. Edwards and A. Elliott and K. Elliott and D. Evans and H. Evans and J. Evans and R. Evans and R. Evans and R. Evans and T. Evans and J. Finch and H. Fisher and M. Flynn and A. Ford and R. Francis and X. Fu and M. Gill and C. Goodwin and B. Gooptu and H. Gregory and R. Gregory and D. Grieve and L. Griffiths and A. Gupta and L. Hall and E. Harris and Harris, {V. C.} and P. Harrison and N. Hart and A. Harvey and M. Harvey and A. Hayday and M. Henderson and Ho, {L. P.} and S. Holden and M. Holland and M. Holmes and A. Hosseini and M. Hotopf and Howard, {L. S.} and Hughes, {A. D.} and J. Hughes and R. Hughes and M. Husain and K. Ismail and T. Jackson and J. Jacob and James, {W. Y.} and Jenkins, {R. G.} and C. Johnson and S. Johnson and Jolley, {C. J.} and D. Jones and G. Jones and H. Jones and I. Jones and L. Jones and Jones, {M. G.} and S. Jones and S. Jose and G. Kaltsakas and S. Kelly and S. Kerr and F. Khan and B. King and S. Knight and S. Kon and S. Kon and C. Laing and D. Lasserson and C. Lawson and D. Lee and Lee, {J. H.} and D. Lewis and J. Lewis and X. Li and L. Lim and A. Lloyd and Lord, {J. M.} and E. Major and M. Malim and {D-C. Man}, W. and S. Mandal and K. Mangion and M. Marks and S. Marsh and B. Marshall and M. Marshall and J. Martin and Martinez, {L. M.} and McMahon, {M. J.} and P. Mehta and C. Miller and C. Mills and J. Mitchell and A. Mohamed and S. Mohammed and A. Morley and A. Morrow and Moss, {A. J.} and P. Moss and A. Neal and Newby, {D. E.} and J. Newman and T. Nicholson and C. O'Brien and M. Ostermann and J. Owen and C. Pariante and S. Parker and B. Patel and M. Patel and S. Patel and S. Payne and L. Pearce and Y. Peng and C. Pennington and H. Plant and S. Plein and J. Porter and J. Porter and N. Powell and J. Pratt and A. Price and C. Price and D. Price and A. Prickett and J. Quigley and Qureshi, {I. N.} and Rahman, {N. M.} and A. Reddy and M. Rees and T. Rees and W. Reynolds and A. Richards and E. Richardson and M. Richardson and K. Roberts and E. Robertson and E. Robinson and L. Robinson and J. Rodger and A. Ross and A. Rowe and A. Rowland and J. Rowland and R. Russell and Sage, {E. K.} and K. Saunders and Saunders, {R. M.} and P. Saunders and Scott, {J. T.} and A. Shah and K. Shah and P. Shah and M. Shankar-Hari and M. Sharma and C. Sharpe and A. Shaw and K. Shaw and J. Simpson and C. Singh and S. Singh and S. Singh and A. Smith and D. Smith and S. Smith and J. Smith and L. Smith and Spencer, {L. G.} and L. Stephenson and I. Stewart and S. Stockdale and R. Stone and Tan, {A. L.} and A. Taylor and C. Taylor and J. Taylor and S. Terry and C. Thomas and Thomas, {D. C.} and S. Thomas and Thomas, {A. K.} and T. Thompson and Thompson, {A. A.R.} and J. Tilley and J. Tomlinson and S. Turner and K. Turner and P. Wade and T. Wainwright and S. Walker and Walsh, {J. A.} and S. Walsh and Ward, {T. J.C.} and E. Watson and L. Watson and J. Watson and McCall, {J. Weir} and C. Welch and S. Wessely and S. West and S. White and J. Whitney and S. Whittaker and J. Wild and B. Williams and N. Williams and J. Williams and J. Willoughby and A. Wilson and D. Wilson and I. Wilson and C. Wood and J. Woods and C. Wright and L. Wright and S. Wright and M. Xu and Yip, {K. P.} and B. Young and S. Young and A. Young and B. Zhao and B. Zheng",
note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",
year = "2023",
month = jun,
doi = "10.1016/j.lanepe.2023.100635",
language = "English",
volume = "29",
journal = "The Lancet Regional Health - Europe",
issn = "2666-7762",
publisher = "Elsevier Ltd",
}
